Recommendations For Cancer Prevention.
Nine of 10 women do not emergency and should not collect genetic testing to see if they are at risk for breast or ovarian cancer, an influential panel of robustness experts announced Monday. The US Preventive Services Task Force (USPSTF) reaffirmed its one-time recommendation from 2005 that only a limited number of women with a family history of knocker cancer be tested for mutations in the BRCA1 and BRCA2 genes that can increase their cancer risk. Even then, these women should review the test with both their family doctor and a genetic counselor before proceeding with the BRCA genetic test, the panel said.
And "Not all men and women who have positive family histories should be tested. It's not at all slow-witted or straightforward," said Dr Virginia Moyer, the task force's chair. Interest mid women in genetic testing for breast cancer has greatly increased, entirely due to Hollywood film star Angelina Jolie's announcement in May that she underwent a double mastectomy because she carried the BRCA1 mutation. A Harris Interactive/HealthDay ask conducted a few months after Jolie's declaration found as many as 6 million women in the United States planned to get medical advice about having a hindrance mastectomy or ovary removal because of the actress' personal decision.
On average, mutations of the BRCA genes can inflation breast cancer risk between 45 percent to 65 percent, according to the American Cancer Society. The emotionally upset is that there are myriad mutations of the BRCA gene. Doctors have identified some mutations that augment breast cancer risk, but there are many more BRCA mutations where the increased risk is either lowly or as yet unknown. "The test is not something that comes back positive or negative.
The test comes back a fit lot of different ways, and that has to be interpreted," Moyer said. "There are a variety of mutations. Often you get what appears to be a cancelling test but we call it an 'uninformative' negative because it just doesn't tell you anything. A old lady would walk away from that with no idea, but worried, and that's not helpful".
Earlier this month, the genetic testing company 23andMe announced it's no longer gift health information with its home-based kit service after the US Food and Drug Administration warned that the check-up is a medical device that requires government approval. The remodelled task force recommendations will be published online Dec 23, 2013 in the Annals of Internal Medicine. The charge force's judgment carries heavy cross within the health care industry.
Thursday 22 January 2015
Friday 16 January 2015
IVF Increases The The Risk Of Thrombosis
IVF Increases The The Risk Of Thrombosis.
Women who became in the through in vitro fertilization (IVF) may have an increased gamble of developing blood clots and potentially baneful artery blockage, Swedish investigators suggest. Although the risk remains small, the chances are especially high during the first trimester compared to women who become pregnant naturally, the researchers said. Blood clots - called venous thromboembolism - can appear in the leg veins and defy free, traveling to the lungs and blocking a main artery. This condition, called pulmonary embolism, can cause problem breathing and even death.
So "There is an increased incidence of pulmonary embolism and venous thrombosis in the midst women pregnant after IVF," said lead researcher Dr Peter Henriksson, a professor of internal pharmaceutical at the Karolinska Institute in Stockholm. "Embolism is the leading cause of motherly mortality during pregnancy. The diagnosis can be elusive, so physicians should be aware of this risk to facilitate the diagnosis".
The jeopardize of clotting during pregnancy isn't confined to women who undergo IVF, another experts said. "Any pregnancy carries a imperil of clotting," said Dr Avner Hershlag, himself of the Center for Human Reproduction at North Shore University Hospital in Manhasset, NY. This is because hormones, uncommonly estrogen, increase during pregnancy, Hershlag said. "This changes what we name the clotting cascade," he said. "There are many factors in blood clotting that can be affected by hormones - especially estrogen".
In addition, the enlarging uterus puts strength on pelvic blood vessels, which can engender to clotting. Some women are advised to limit their movement to reduce the risk of clotting, Hershlag noted. Although it's unclear why women who go through IVF have a greater risk of clotting, Hershlag speculates that it could be due to fertility treatments that widen estrogen even beyond levels normally associated with pregnancy.
Women who became in the through in vitro fertilization (IVF) may have an increased gamble of developing blood clots and potentially baneful artery blockage, Swedish investigators suggest. Although the risk remains small, the chances are especially high during the first trimester compared to women who become pregnant naturally, the researchers said. Blood clots - called venous thromboembolism - can appear in the leg veins and defy free, traveling to the lungs and blocking a main artery. This condition, called pulmonary embolism, can cause problem breathing and even death.
So "There is an increased incidence of pulmonary embolism and venous thrombosis in the midst women pregnant after IVF," said lead researcher Dr Peter Henriksson, a professor of internal pharmaceutical at the Karolinska Institute in Stockholm. "Embolism is the leading cause of motherly mortality during pregnancy. The diagnosis can be elusive, so physicians should be aware of this risk to facilitate the diagnosis".
The jeopardize of clotting during pregnancy isn't confined to women who undergo IVF, another experts said. "Any pregnancy carries a imperil of clotting," said Dr Avner Hershlag, himself of the Center for Human Reproduction at North Shore University Hospital in Manhasset, NY. This is because hormones, uncommonly estrogen, increase during pregnancy, Hershlag said. "This changes what we name the clotting cascade," he said. "There are many factors in blood clotting that can be affected by hormones - especially estrogen".
In addition, the enlarging uterus puts strength on pelvic blood vessels, which can engender to clotting. Some women are advised to limit their movement to reduce the risk of clotting, Hershlag noted. Although it's unclear why women who go through IVF have a greater risk of clotting, Hershlag speculates that it could be due to fertility treatments that widen estrogen even beyond levels normally associated with pregnancy.
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