A New Cause Of Heart Disease

A New Cause Of Heart Disease.
A genetic varying occurring in a significant horde of people with heart disease appears to raise the odds for heart fall or death by 38 percent, a new study suggests. This "stress reaction gene," which Duke University scientists then linked to an overproduction of cortisol, a stress hormone that can strike heart risks, was found in about 17 percent of men and 3 percent of women with heart disease. The unique finding, also from Duke researchers, offers a potential new explanation for a biological predisposition to hub disease and early death, the study authors said.

The research may finally lead to personalized therapies for heart disease patients. "This is very exciting, but it's very preliminary. It certainly merits further investigation," said look at author Beverly Brummett, an associated professor of psychiatry and behavioral sciences at the Duke University School of Medicine. "Down the line, if the findings were replicated, then the next measure would be to test people on a widespread basis for the gene and watch them more closely".

The inspect was published Dec 18, 2013 in the journal PLoS One. Heart blight is the No. 1 killer of Americans. Its most common cause is the narrowing of coronary arteries, which can steer to heart attacks, according to the US National Library of Medicine. About 600000 people in the United States pass away each year due to heart disease. Brummett and her colleagues ran genetic analyses on more than 6100 bloodless men and women who were part of a large database of Duke heart catheterization patients.

Two-thirds of the participants were men. Patients carrying the genetic deviant experienced the highest rates of sentiment attacks and deaths over an average follow-up period of six years. Despite adjusting the results for marrow disease risk factors such as age, obesity and smoking history, the genetic feature was associated with a 38 percent higher risk of heart attack and death. This breed of association, however, does not necessarily prove a cause-and-effect relationship.

Dr Nieca Goldberg, medical pilot of New York University's Women's Heart Program, said the research was "very exciting. There's a lot of bull going on about personalized medicine and we're trying to really individualize our therapies," said Goldberg, who was not labyrinthine in the study. "This identifies a genetic trait that predisposes occupy to heart disease, and once this is tailored a little more and we have more research, it would be exciting if this genetic test became commercially available," said Goldberg, who is also a spokesperson for the American Heart Association medical. Goldberg said it would be usable to conscious how frequently the gene variant occurs in other ethnic groups, such as blacks, Asians and Latinos, since all of the contemplation participants were white.