Statins Do Not Reduce The Risk Of Colon Cancer

Statins Do Not Reduce The Risk Of Colon Cancer.
Statins don't take down the hazard of colorectal cancer, and may even increase the chances of developing precancerous polyps, unusual research suggests. Statins are widely prescribed cholesterol-lowering drugs sold in a contrast of generic forms and brand names, including Lipitor, Crestor and Zocor.

Yet, researchers stressed that the results are "not conclusive," and that man taking statins to lower cholesterol and reduce their peril of heart attack should continue taking the drugs. "We found patients in this study taking statins for more than three years tended to arise more premalignant colon lesions," said study author Dr Monica Bertagnolli, principal of the division of surgical oncology at Brigham and Women's Hospital and a professor of surgery at Harvard Medical School. "This is an gripping finding that needs to be followed up, but it should not raise alarm. No one should dam taking their statins."

The study is to be presented Monday at the American Association for Cancer Research annual engagement in Washington, DC, and it is also published online in the journal Cancer Prevention Research. The figures used in the analysis was from an earlier clinical trial to determine if the cox-2 sedative celecoxib (Celebrex) could be used to prevent colon cancer.

That trial included 2035 folk who were at high risk of colon cancer and had already been diagnosed with precancerous polyps, or adenomas. That study, published in 2006, found the celecoxib reduced the experience of adenomas, but it also more than doubled the risk of heart undertake and other serious cardiac events.

As a result, celecoxib is not used to prevent colon cancer, though it is still prescribed for its unusual use, to treat arthritis. About 36 percent of the people in the trial also happened to be taking statins, enabling researchers to go back and behold if statin use had any effect on developing adenomas.

The researchers found that patients who had been in the placebo gather and who used statins at any time were no less likely to develop adenomas over a five-year spell compared with those patients who never used statins. For those who took statins for three years or longer, the chances of developing the adenomas were nearly 40 percent higher than those not on statins.

Those taking celecoxib and statins did not have an increased unintentional of developing adenomas, quite because the anti-tumor effects of celecoxib canceled out any tumor-promoting effectiveness of the statins, according to the study. While statins aren't helpful in preventing colorectal cancer, experts from the American Cancer Society also urged ancestors to continue taking statins for cardiovascular health.

So "The counsel of higher risk of colorectal polyp recurrence among a subgroup of statin users in this deliberate over may be due to chance and should not raise concerns," said Eric Jacobs, the American Cancer Society's tactical director of pharmacoepidemiology. "A similar previous study of polyp recurrence did not summon higher risk among statin users.

Statins are valuable drugs, proven to reduce jeopardy of heart disease. Results of this study should not influence decisions about statin use therapy." For now, the best route to prevent colon cancer is to make sure you get a colonoscopy screening at age 50, or earlier for those with a people history.