Treatment Of Diabetes Is Different For Men And Women

Treatment Of Diabetes Is Different For Men And Women.
Widely hand-me-down diabetes drugs have particular effects on men's and women's hearts, a rejuvenated study suggests. Researchers examined how three commonly prescribed treatments for type 2 diabetes laid hold of 78 patients who were divided into three groups. One group took metformin alone, the subsequent group took metformin plus rosiglitazone (sold under the maker name Avandia) and the third group took metformin plus Lovaza, a type of fish oil. Metformin reduces blood sugar assembly by the liver and improves insulin sensitivity.

Rosiglitazone also improves insulin consciousness and moves free fatty acids out of the blood. Lovaza lowers blood levels of another classification of fat called triglycerides. The researchers found that the drugs had very several and sometimes opposite effects on the hearts of men and women, even as the drugs controlled blood sugar equally well in both genders. The reading appears in the December issue of the American Journal of Physiology - Heart and Circulatory Physiology.

Although metformin had unambiguous heart effects in women, it caused the boldness metabolism of men to burn less sugar and more fats. Chronic burning of fat by the pity results in harmful changes that can lead to heart failure, said the researchers, from the Washington University School of Medicine in St Louis. "Instead of making determination metabolism more normal in men, metformin solely made it worse, looking even more like a diabetic heart," study major author Dr Robert Gropler said in a university news release.

And "But in women, metformin had the desired influence - lowering fat metabolism and increasing glucose sensitivity by the heart". Taking either rosiglitazone or Lovaza with metformin seemed to reduce some of the negative heart goods of metformin alone in men. Taking rosiglitazone in addition to metformin further improved women's mettle metabolism, compared to taking metformin alone.

The addition of Lovaza to metformin did not have a strong effect either method for men or women, the researchers said. "Our study suggests that we need to better define which therapies are optimal for women with diabetes and which ones are optimal for men," said Gropler, a professor of radiology. The den did not, however, substantiate a cause-and-effect link between the drug combinations and affection changes full article. It showed only an association.