Smoking And Weight Gain Increases The Death Rate From Prostate Cancer

Smoking And Weight Gain Increases The Death Rate From Prostate Cancer.
Men treated for prostate cancer who smoke or put on glut pounds amass their discrepancy of disease recurrence and of dying from the illness, two new studies show. The findings were presented Tuesday at the American Association for Cancer Research's annual conclave in Washington, DC.

In the fundamental report, a team led by Dr Jing Ma, an associate professor of pharmaceutical at Brigham and Women's Hospital in Boston, found that obesity and smoking may not be risk factors for developing prostate cancer, but they do augmentation the odds that a man who has the illness will die from it. Being overcast and smoking "predispose men to a significantly high risk of cancer-specific and all-cause mortality," Ma said during a Tuesday matinal news conference.

"Compared to lean non-smokers, obese smokers had the highest jeopardy of prostate cancer mortality". For the study, Ma's team collected data on more than 2700 men with prostate cancer who took role in the Physicians Health Study. Over 27 years of follow-up, 882 of the men died, 11 percent from the cancer.

The researchers found that both avoirdupois move further and smoking boosted the risk for dying from the cancer. In fact, every five-point flourish in body mass index (BMI) increased the risk for dying from prostate cancer by 52 percent. BMI is a assessment of height versus weight, with the threshold of overweight set at a BMI of 25 and the sill for obesity set at a BMI of 30.

In addition, men who smoked increased their risk for dying from the cancer by 55 percent, compared with men who never smoked, the muse about found. "These data underscore the lack for implementing effective preventive strategies for weight control and reducing tobacco use in both fit men as well as prostate cancer patients".

In a second report, a team led by Corinne E Joshu, a postdoctoral colleague in the department of epidemiology at Johns Hopkins Bloomberg School of Public Health, found that men who gained preponderance after having their prostate removed were almost twice as likely to discover their cancer return as were men who maintained their weight. "Weight gain may increase the risk of prostate cancer recurrence after prostatectomy," Joshu said during the AACR advice conference.

"Obesity, especially among serene men, may also contribute to the risk of prostate cancer recurrence". For the study, Joshu's crew collected data on more than 1300 men with localized prostate cancer who underwent prostatectomy between 1993 and 2006. In addition, the men completed a examine on diet, lifestyle and other factors such as weight, zenith and physical activity five years before surgery and again one year after the procedure.

By the end of the study in 2008, 102 men catchword their prostate cancer return. These men were older, more promising to have more aggressive tumors and less likely to have a family history of prostate cancer, compared with men whose cancer did not return, the researchers found.

Furthermore, men who had gained at least five pounds before surgery or up to one year after surgery had almost a two-fold greater luck of since their cancer return than did men who did not gain weight. Five years before undergoing a prostatectomy, 54 percent of the men were overweight and nine percent were obese.

Among men who gained consequence in the year after surgery, the norm weight gain was about 10 pounds. Becoming chubby after surgery increased the risk for a recurrence of prostate cancer 1,7-fold, the researchers said. "By avoiding plumpness and weight gain men with prostate cancer may be able to both ward recurrence but also improve their overall well-being."

In another report presented Monday at the meeting, Katherine A McGlynn, a superior investigator at the US National Cancer Institute, said that the proper lever of diabetes might cut people's odds of developing liver cancer. The researchers worn the SEER-Medicare linked database to collect data on more than 5600 people diagnosed with liver cancer.

Among them, 63 percent of the cancers were associated with conditions such as diabetes, alcohol-related disorders and hepatitis C, long-lasting hepatitis B, weight and several rare metabolic disorders. The relation was highest for Asians, at 67,9 percent, and lowest for blacks, at 53,5 percent, the researchers noted.

Among the endanger factors, the leading cause of liver cancer was diabetes (33,5 percent). Other factors predetermined to be contributors to liver malignancy were alcohol-related disorders (23,9 percent), hepatitis C (20,7 percent), hepatitis B (5,7 percent), bleu metabolic disorders (3,1 percent) and size (2,7 percent).

That left 37 percent of liver cancers with indeterminate origins more information. "We have a big way to go because one-third of the tumors are not explained by these risk factors," she said during Tuesday's item conference.