Treatment Of Heart Attack With The Help Of Stem Cells From Belly Fat

Treatment Of Heart Attack With The Help Of Stem Cells From Belly Fat.
Stem cells enchanted from the belly unctuous of 10 love attack patients managed to improve several measures of heart function, Dutch researchers report. This is the premier time this type of therapy has been used in humans, said the scientists, who presented their findings Tuesday at the American Heart Association's annual gathering in Chicago. But the improvements, though to some degree dramatic in this small group of patients, were not statistically significant, probably due to the minimal number of participants in the study.

And another expert urged caution when interpreting the results. "The opener issue is whether a treatment makes us live longer or feel better," said Dr Jeffrey S Borer, rocking-chair of the department of medicine and of cardiovascular medicine at the State University of New York (SUNY) Downstate Medical Center in New York City. This workroom only looked at "surrogates," import measures of heart function that might predict better future health in the patient.

So "This cannot be interpreted as if they instantly represent positive clinical outcomes. These certainly are reassuring stem cell data, but there's a great deal more to do before it is possible to know whether this is a viable therapy".

Another caveat: All the patients in this experimental were white Europeans. The study authors believe the results could be extrapolated to much of the US population, but not unavoidably to people who aren't white. Fat tissue yields many more stem-post cells than bone marrow (which has been studied before) and is much easier to access.

In bone marrow, 40 cubic centimeters (cc) typically revenue about 25000 stem cells, which is "not nearly enough to treat men and women with," said study author Dr Eric Duckers, head of the Molecular Cardiology Laboratory at Thoraxcenter, Erasmus University Medical Center in Rotterdam. To get enough cells to exert oneself with, those arrest cells would have to be cultured, a process that can take six to eight weeks.

By contrast, 100 cc's of oily tissue yield millions of stem cells, plenty to employment with. A hundred cc's is about the size of a coffee cup - a European coffee cup, not the mega-size of American coffee containers, Duckers emphasized. "With that many cells, you can transport them and give them to the unaggressive right away as they come into the hospital".

All patients in this double-blind, placebo-controlled study (11 men and three women) arrived at the sickbay having suffered a severe heart attack. All then underwent cardiac catheterization to assess blood flow, followed by percutaneous coronary intervention (PCI), more commonly known as angioplasty, to mend blood flow.

Within 24 hours of the boldness attack, doctors performed liposuction to exterminate fat tissue, isolated 20 million stem cells and gave them back to the patients through a catheter. The infusion took no more than 10 minutes. Ten patients received trunk cells and four received a placebo infusion. "It was done very, very quickly, all in the same day".

Six months after the procedure, bows stall patients had better blood flow (more than triple the dress down compared to patients getting a placebo), a 5,7 percent increase in heart pumping ability, and a 50 percent reduction in scarring of fundamentals muscle (from 31,6 percent right after the pity attack to 15,4 percent). Placebo patients saw no decrease in scarring.

And "In theory the use of stalk cells to improve myocardial perfusion blood flow and cardiac performance is very positive - but to the present time, although many approaches to stem cell use have been tested, there really has not yet been evidence of a clinically gainful important result. That doesn't mean that stem cell research isn't an material lead to follow" info. The Dutch research team is now embarking on a trial that will at long last enroll 375 heart attack patients at 35 medical centers in the European Union to further probe stem cell infusions.