Treatment Of Heart Attack With The Help Of Stem Cells From Belly Fat.
Stem cells enchanted from the belly unctuous of 10 love attack patients managed to improve several measures of heart function, Dutch researchers report. This is the premier time this type of therapy has been used in humans, said the scientists, who presented their findings Tuesday at the American Heart Association's annual gathering in Chicago. But the improvements, though to some degree dramatic in this small group of patients, were not statistically significant, probably due to the minimal number of participants in the study.
And another expert urged caution when interpreting the results. "The opener issue is whether a treatment makes us live longer or feel better," said Dr Jeffrey S Borer, rocking-chair of the department of medicine and of cardiovascular medicine at the State University of New York (SUNY) Downstate Medical Center in New York City. This workroom only looked at "surrogates," import measures of heart function that might predict better future health in the patient.
So "This cannot be interpreted as if they instantly represent positive clinical outcomes. These certainly are reassuring stem cell data, but there's a great deal more to do before it is possible to know whether this is a viable therapy".
Another caveat: All the patients in this experimental were white Europeans. The study authors believe the results could be extrapolated to much of the US population, but not unavoidably to people who aren't white. Fat tissue yields many more stem-post cells than bone marrow (which has been studied before) and is much easier to access.
In bone marrow, 40 cubic centimeters (cc) typically revenue about 25000 stem cells, which is "not nearly enough to treat men and women with," said study author Dr Eric Duckers, head of the Molecular Cardiology Laboratory at Thoraxcenter, Erasmus University Medical Center in Rotterdam. To get enough cells to exert oneself with, those arrest cells would have to be cultured, a process that can take six to eight weeks.
Showing posts with label attack. Show all posts
Showing posts with label attack. Show all posts
Thursday 16 January 2020
Friday 27 December 2019
Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation
Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation.
Morphine appears to diet the effectiveness of the commonly reach-me-down blood-thinning narcotize Plavix, which could hamper emergency-room efforts to treat heart attack victims, Austrian researchers report. The verdict could create serious dilemmas in the ER, where doctors have to weigh a centre patient's intense pain against the need to break up and prevent blood clots, said Dr Deepak Bhatt, foreman director of interventional cardiovascular programs at Brigham and Women's Hospital Heart and Vascular Center, in Boston. "If a serene is having crushing heart pain, you can't just determine them to tough it out, and morphine is the most commonly used medication in that situation," said Bhatt, who was not affected in the study.
And "Giving them morphine is the humane thing to do, but it could also create delays in care". Doctors will have to be very careful if a heart attack patient needs to have a stent implanted. Blood thinners are severe in preventing blood clots from forming around the stent. "If that predicament is unfolding, it requires a little bit of extra thought on the part of the physician whether they want to give that full slug of morphine or not".
About half of the 600000 stent procedures that make use of place in the United States each year befall as the result of a heart attack, angina or other acute coronary syndrome. The Austrian researchers focused on 24 in good people who received either a dose of Plavix with an injection of morphine or a placebo drug. Morphine delayed the wit of Plavix (clopidogrel) to thin a patient's blood by an ordinary of two hours, the researchers said.
Morphine appears to diet the effectiveness of the commonly reach-me-down blood-thinning narcotize Plavix, which could hamper emergency-room efforts to treat heart attack victims, Austrian researchers report. The verdict could create serious dilemmas in the ER, where doctors have to weigh a centre patient's intense pain against the need to break up and prevent blood clots, said Dr Deepak Bhatt, foreman director of interventional cardiovascular programs at Brigham and Women's Hospital Heart and Vascular Center, in Boston. "If a serene is having crushing heart pain, you can't just determine them to tough it out, and morphine is the most commonly used medication in that situation," said Bhatt, who was not affected in the study.
And "Giving them morphine is the humane thing to do, but it could also create delays in care". Doctors will have to be very careful if a heart attack patient needs to have a stent implanted. Blood thinners are severe in preventing blood clots from forming around the stent. "If that predicament is unfolding, it requires a little bit of extra thought on the part of the physician whether they want to give that full slug of morphine or not".
About half of the 600000 stent procedures that make use of place in the United States each year befall as the result of a heart attack, angina or other acute coronary syndrome. The Austrian researchers focused on 24 in good people who received either a dose of Plavix with an injection of morphine or a placebo drug. Morphine delayed the wit of Plavix (clopidogrel) to thin a patient's blood by an ordinary of two hours, the researchers said.
Sunday 8 December 2019
Shoveling Snow Leads To Death
Shoveling Snow Leads To Death.
Shoveling snow can snowball your imperil of heart attack, and you should take precautions to protect yourself, an expert says. "When the temperature front drops, our blood vessels narrow to prevent our bodies from losing heat," Dr Holly Andersen, gaffer of education and outreach at the Ronald O Perelman Heart Institute of NewYork-Presbyterian Hospital/Weill Cornell Medical Center, said in a dispensary news release. "This is a fool response that can also put people with heart conditions and those involved in strenuous exercise at greater peril of having a heart attack".
Andersen said shoveling snow is one of the most strenuous and dangerous winter activities. It can leg up blood pressure and, combined with the effects of frigid temperatures, can significantly proliferate heart attack risk. Andersen offered the following advice for safe shoveling and good courage health this winter.
Shoveling snow can snowball your imperil of heart attack, and you should take precautions to protect yourself, an expert says. "When the temperature front drops, our blood vessels narrow to prevent our bodies from losing heat," Dr Holly Andersen, gaffer of education and outreach at the Ronald O Perelman Heart Institute of NewYork-Presbyterian Hospital/Weill Cornell Medical Center, said in a dispensary news release. "This is a fool response that can also put people with heart conditions and those involved in strenuous exercise at greater peril of having a heart attack".
Andersen said shoveling snow is one of the most strenuous and dangerous winter activities. It can leg up blood pressure and, combined with the effects of frigid temperatures, can significantly proliferate heart attack risk. Andersen offered the following advice for safe shoveling and good courage health this winter.
Friday 19 August 2016
Stem Cells From A New Source For The Treatment Of The Heart
Stem Cells From A New Source For The Treatment Of The Heart.
Stem cells from the amniotic sac that surrounds a fetus may someday be old to renewal impair caused by a heart attack, Japanese researchers report. The work, so far only conducted in animals, raises the feasibility of a non-controversial source of stem cells to expound not only heart disease but also many other conditions, said Dr Shunichiro Miyoshi, an assistant professor in the cardiology subdivision at the Keio University School of Medicine, and co-author of a report in the May 28 online dissemination of Circulation Research. "I believe these cells may be utilized in the treatment of autoimmune diseases such as SLA systemic lupus erythematosus and rheumatoid arthritis".
The amniotic sac is typically discarded after childbirth. SLA is an autoimmune disability in which the body's exempt system cells mistakenly seize healthy tissue. The cells that Miyoshi and his colleagues have used in mouse studies can simply be obtained in large numbers and offer another major advantage: they bypass the need to match donor-recipient apartment typing.
So "At the present time there is no barrier for clinical utilization. We can secure amniotic membrane from every delivery. We do not need to match donor-recipient matching of complicated HLA typing". HLA refers to the protein markers that are found on most of the body's cells. Transplanted cells that be at variance from the recipient's HLA quintessence will be attacked and destroyed by the immune system.
The Keio researchers have begun a series of studies aimed at the good-natured use of the amniotic stem cells. "Now we are performing the test on a swine model. Immediately after we get a good result, we are planning to perform clinical trials. I maintain it will go on within a few years. But it may depend on the strength of our government regulation".
The journal report describes laboratory make in which stem cells obtained from amniotic membranes were transformed into heart cells, 33 percent of which form spontaneously and which improved rat heart function by more than 34 percent when injected two weeks after a insensitivity attack. The injected cells decreased the room of heart damage by 13 percent to 18 percent and survived for more than four weeks in the rats without the use of drugs to run-in immune rejection. The amniotic cells are much easier to convert into kindness cells than stem cells from other sources, such as bone marrow or fat.
Stem cells from the amniotic sac that surrounds a fetus may someday be old to renewal impair caused by a heart attack, Japanese researchers report. The work, so far only conducted in animals, raises the feasibility of a non-controversial source of stem cells to expound not only heart disease but also many other conditions, said Dr Shunichiro Miyoshi, an assistant professor in the cardiology subdivision at the Keio University School of Medicine, and co-author of a report in the May 28 online dissemination of Circulation Research. "I believe these cells may be utilized in the treatment of autoimmune diseases such as SLA systemic lupus erythematosus and rheumatoid arthritis".
The amniotic sac is typically discarded after childbirth. SLA is an autoimmune disability in which the body's exempt system cells mistakenly seize healthy tissue. The cells that Miyoshi and his colleagues have used in mouse studies can simply be obtained in large numbers and offer another major advantage: they bypass the need to match donor-recipient apartment typing.
So "At the present time there is no barrier for clinical utilization. We can secure amniotic membrane from every delivery. We do not need to match donor-recipient matching of complicated HLA typing". HLA refers to the protein markers that are found on most of the body's cells. Transplanted cells that be at variance from the recipient's HLA quintessence will be attacked and destroyed by the immune system.
The Keio researchers have begun a series of studies aimed at the good-natured use of the amniotic stem cells. "Now we are performing the test on a swine model. Immediately after we get a good result, we are planning to perform clinical trials. I maintain it will go on within a few years. But it may depend on the strength of our government regulation".
The journal report describes laboratory make in which stem cells obtained from amniotic membranes were transformed into heart cells, 33 percent of which form spontaneously and which improved rat heart function by more than 34 percent when injected two weeks after a insensitivity attack. The injected cells decreased the room of heart damage by 13 percent to 18 percent and survived for more than four weeks in the rats without the use of drugs to run-in immune rejection. The amniotic cells are much easier to convert into kindness cells than stem cells from other sources, such as bone marrow or fat.
Thursday 14 January 2016
Patients Become More Aware Of Some Signs Of Heart Attack And Had To Seek Help
Patients Become More Aware Of Some Signs Of Heart Attack And Had To Seek Help.
Patients who have a crux malign and sustain procedures to open blocked arteries are getting proven treatments in US hospitals faster and more safely than ever before, according to the results of a large-scale study. Data on more than 131000 empathy attack patients treated at about 250 hospitals from January 2007 through June 2009 also showed that the patients themselves have become more enlightened of the signs of marrow attack and are showing up at hospitals faster for help. Lead researcher Dr Matthew T Roe, an collaborator professor of medicine at Duke University Medical Center and the Duke Clinical Research Institute, thinks a trust of improved treatment guidelines and the ability of hospitals to flock data on the quality of their care accounts for many of the improvements the researchers found.
And "We are in an era of healthiness care reform where we shouldn't be accepting inferior quality of care for any condition. Patients should be cognizant that we are trying to be on the leading edge of making rapid improvements in care and sustaining those. Patients should also be apprised that the US is on the leading front of cardiovascular care worldwide". The report is published in the July 20 children of the Journal of the American College of Cardiology.
Roe's team, using data from two monumental registry programs of the American College of Cardiology Foundation's National Cardiovascular Data Registry, found there were significant improvements in a digit of areas in heart attack care. An increase from 90,8 percent to 93,8 percent in the use of treatments to fine blocked blood vessels. An widen from 64,5 percent to 88 percent in the number of patients given angioplasty within 90 minutes of arriving at the hospital. An recovery from 89,6 percent to 92,3 percent in performance scores that fit timeliness and appropriateness of therapy. Better prescribing of blood thinners. A significant drop in convalescent home death rates among heart patients. Improvement in prescribing necessary medications, including aspirin, anti-platelet drugs, statins, beta blockers, angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers. Improvement in counseling patients to resign smoking and referring patients to cardiac rehabilitation.
In addition, patients were more wise of the signs of boldness attack and the time from the onset of the attack until patients arrived at the asylum was cut from an average 1,7 hours to 1,5 hours, the researchers found. Roe's unit also found that for patients undergoing an angioplasty. There was an increase in the complexity of the procedure, including more patients with more challenging conditions. There were reductions in complications, including bleeding or mistreatment to the arteries. There were changes in medications to curb blood clots, which reflect the results of clinical trials and recommendations in unfledged clinical practice guidelines. And there was a reduction in the use of older drug-eluting stents, but an distend in the use of new types of drug-eluting stents.
Patients who have a crux malign and sustain procedures to open blocked arteries are getting proven treatments in US hospitals faster and more safely than ever before, according to the results of a large-scale study. Data on more than 131000 empathy attack patients treated at about 250 hospitals from January 2007 through June 2009 also showed that the patients themselves have become more enlightened of the signs of marrow attack and are showing up at hospitals faster for help. Lead researcher Dr Matthew T Roe, an collaborator professor of medicine at Duke University Medical Center and the Duke Clinical Research Institute, thinks a trust of improved treatment guidelines and the ability of hospitals to flock data on the quality of their care accounts for many of the improvements the researchers found.
And "We are in an era of healthiness care reform where we shouldn't be accepting inferior quality of care for any condition. Patients should be cognizant that we are trying to be on the leading edge of making rapid improvements in care and sustaining those. Patients should also be apprised that the US is on the leading front of cardiovascular care worldwide". The report is published in the July 20 children of the Journal of the American College of Cardiology.
Roe's team, using data from two monumental registry programs of the American College of Cardiology Foundation's National Cardiovascular Data Registry, found there were significant improvements in a digit of areas in heart attack care. An increase from 90,8 percent to 93,8 percent in the use of treatments to fine blocked blood vessels. An widen from 64,5 percent to 88 percent in the number of patients given angioplasty within 90 minutes of arriving at the hospital. An recovery from 89,6 percent to 92,3 percent in performance scores that fit timeliness and appropriateness of therapy. Better prescribing of blood thinners. A significant drop in convalescent home death rates among heart patients. Improvement in prescribing necessary medications, including aspirin, anti-platelet drugs, statins, beta blockers, angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers. Improvement in counseling patients to resign smoking and referring patients to cardiac rehabilitation.
In addition, patients were more wise of the signs of boldness attack and the time from the onset of the attack until patients arrived at the asylum was cut from an average 1,7 hours to 1,5 hours, the researchers found. Roe's unit also found that for patients undergoing an angioplasty. There was an increase in the complexity of the procedure, including more patients with more challenging conditions. There were reductions in complications, including bleeding or mistreatment to the arteries. There were changes in medications to curb blood clots, which reflect the results of clinical trials and recommendations in unfledged clinical practice guidelines. And there was a reduction in the use of older drug-eluting stents, but an distend in the use of new types of drug-eluting stents.
Friday 13 September 2013
The Link Between Recurrent Miscarriages And The Risk Of Heart Attacks In Women
The Link Between Recurrent Miscarriages And The Risk Of Heart Attacks In Women.
Women who deteriorate repetitious miscarriages have a greatly increased jeopardize of guts attack later in life, finds a supplementary study. Researchers analyzed data from more than 11500 women who had been fruitful at least once and found that 25 percent had experienced at least one detectable miscarriage, 18 percent had had at least one abortion and 2 percent had trained a stillbirth. Over a bolstering of about 10 years, 82 of the women had a consideration attack and 112 had a stroke howporstarsgrowit.com. There was no significant fellowship between any type of pregnancy loss and stroke, said the researchers.
Each breakdown increased heart attack risk by 40 percent, and having more than two miscarriages increased the chance by more than fourfold. Women who had more than three miscarriages had a ninefold increased risk. The study, published online Dec 1, 2010 in the list Heart, also found that having at least one stillbirth increased the gamble of enthusiasm devour 3,5 times.
The degree of risk associated with persistent miscarriage decreased when the researchers factored in major pith attack factors such as smoking, weight and alcohol consumption, but the imperil was still five times higher than normal. "These results suggest that women who competent spontaneous pregnancy loss are at a substantially higher endanger of heart attack later in life," the researchers wrote in a scandal release from the publisher. "Recurrent miscarriage and stillbirth are staunch gender predictors for this and thus should be considered as important indicators for monitoring cardiovascular hazard factors and preventive measures," they said.
Women who deteriorate repetitious miscarriages have a greatly increased jeopardize of guts attack later in life, finds a supplementary study. Researchers analyzed data from more than 11500 women who had been fruitful at least once and found that 25 percent had experienced at least one detectable miscarriage, 18 percent had had at least one abortion and 2 percent had trained a stillbirth. Over a bolstering of about 10 years, 82 of the women had a consideration attack and 112 had a stroke howporstarsgrowit.com. There was no significant fellowship between any type of pregnancy loss and stroke, said the researchers.
Each breakdown increased heart attack risk by 40 percent, and having more than two miscarriages increased the chance by more than fourfold. Women who had more than three miscarriages had a ninefold increased risk. The study, published online Dec 1, 2010 in the list Heart, also found that having at least one stillbirth increased the gamble of enthusiasm devour 3,5 times.
The degree of risk associated with persistent miscarriage decreased when the researchers factored in major pith attack factors such as smoking, weight and alcohol consumption, but the imperil was still five times higher than normal. "These results suggest that women who competent spontaneous pregnancy loss are at a substantially higher endanger of heart attack later in life," the researchers wrote in a scandal release from the publisher. "Recurrent miscarriage and stillbirth are staunch gender predictors for this and thus should be considered as important indicators for monitoring cardiovascular hazard factors and preventive measures," they said.
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