Stem Cells From A New Source For The Treatment Of The Heart

Stem Cells From A New Source For The Treatment Of The Heart.
Stem cells from the amniotic sac that surrounds a fetus may someday be old to renewal impair caused by a heart attack, Japanese researchers report. The work, so far only conducted in animals, raises the feasibility of a non-controversial source of stem cells to expound not only heart disease but also many other conditions, said Dr Shunichiro Miyoshi, an assistant professor in the cardiology subdivision at the Keio University School of Medicine, and co-author of a report in the May 28 online dissemination of Circulation Research. "I believe these cells may be utilized in the treatment of autoimmune diseases such as SLA systemic lupus erythematosus and rheumatoid arthritis".

The amniotic sac is typically discarded after childbirth. SLA is an autoimmune disability in which the body's exempt system cells mistakenly seize healthy tissue. The cells that Miyoshi and his colleagues have used in mouse studies can simply be obtained in large numbers and offer another major advantage: they bypass the need to match donor-recipient apartment typing.

So "At the present time there is no barrier for clinical utilization. We can secure amniotic membrane from every delivery. We do not need to match donor-recipient matching of complicated HLA typing". HLA refers to the protein markers that are found on most of the body's cells. Transplanted cells that be at variance from the recipient's HLA quintessence will be attacked and destroyed by the immune system.

The Keio researchers have begun a series of studies aimed at the good-natured use of the amniotic stem cells. "Now we are performing the test on a swine model. Immediately after we get a good result, we are planning to perform clinical trials. I maintain it will go on within a few years. But it may depend on the strength of our government regulation".

The journal report describes laboratory make in which stem cells obtained from amniotic membranes were transformed into heart cells, 33 percent of which form spontaneously and which improved rat heart function by more than 34 percent when injected two weeks after a insensitivity attack. The injected cells decreased the room of heart damage by 13 percent to 18 percent and survived for more than four weeks in the rats without the use of drugs to run-in immune rejection. The amniotic cells are much easier to convert into kindness cells than stem cells from other sources, such as bone marrow or fat.