Rheumatoid Arthritis And Shingles.
The newest medications old to scrutinize autoimmune diseases such as rheumatoid arthritis don't appear to raise the risk of developing shingles, experimental research indicates. There has been concern that these medications, called anti-tumor necrosis factor (anti-TNF) drugs, might prolong the chances of a shingles infection (also known as herpes zoster) because they create by suppressing a part of the immune system that causes the autoimmune attack. "These are commonly in use drugs for people with rheumatoid arthritis and other autoimmune diseases, and the issue was whether or not they increased the risk of shingles.
We found there is no increased hazard when using these drugs, which was reassuring," said study author Dr Kevin Winthrop, friend professor of infectious disease and public health and preventive medicine at Oregon Health and Science University in Portland. Results of the contemplate are published in the March 6 issue of the Journal of the American Medical Association.
Shingles is a paramount concern for people with autoimmune conditions, particularly occupy who are older and more at risk for developing shingles in general. Shingles is caused when the same virus that causes chickenpox is reactivated. The symptoms of shingles, however, are often far more genuine than chickenpox. It typically starts with a ardent or tingling pain, which is followed by the appearance of fluid-filled blisters, according to the US National Institutes of Neurological Disorders and Stroke.
Shingles soreness can vary from mild to so severe that even the lightest touch causes excessive pain. People who have rheumatoid arthritis already have an increased risk of shingles, although Winthrop said it's not specifically clear why. It may be due to older age, or it may have something to do with the disease itself. Rheumatoid arthritis and other autoimmune conditions are treated with many unlike medications that help dampen the immune set and, hopefully, the autoimmune attack.
Showing posts with label autoimmune. Show all posts
Showing posts with label autoimmune. Show all posts
Wednesday 8 January 2020
Wednesday 29 November 2017
Type 1 Diabetes And Thyroid Disease
Type 1 Diabetes And Thyroid Disease.
People who have category 1 diabetes are more promising than others to develop an autoimmune thyroid condition. Though estimates vary, the gait of thyroid disease - either under- or overactive thyroid - may be as high as 30 percent in males and females with type 1 diabetes, according to Dr Betul Hatipoglu, an endocrinologist with the Cleveland Clinic in Ohio. And the likelihood are especially high for women, whether they have diabetes or not noting that women are eight times more like as not than men to develop thyroid disease.
And "I tell my patients thyroid infection and type 1 diabetes are sister diseases, like branches of a tree. Each is different, but the source is the same. And, that root is autoimmunity, where the immune system is attacking your own beneficial endocrine parts". Hatipoglu also noted that autoimmune diseases often run in families.
A grandparent may have had thyroid problems, while an heir may develop type 1 diabetes. "People who have one autoimmune blight are at risk for another," explained Dr Lowell Schmeltz, an endocrinologist and assistant professor at the Oakland University-William Beaumont School of Medicine in Royal Oak, Mich.
So "There's some genetic jeopardize that links these autoimmune conditions, but we don't separate what environmental triggers make them activate," he explained, adding that the antibodies from the invulnerable system that destroy the healthy tissue are different in type 1 diabetes than in autoimmune thyroid disease. Hatipoglu said that public with type 1 diabetes are also more tending to celiac disease, another autoimmune condition.
Type 1 diabetes occurs when the immune arrangement mistakenly attacks the insulin-producing cells in the pancreas, destroying them. Insulin is a hormone that's compelling for the metabolism of carbohydrates in foods. Without enough insulin, blood sugar levels can skyrocket, important to serious complications or death. People who have type 1 diabetes have to replace the frenzied insulin, using shots of insulin or an insulin pump with a tube inserted under the skin.
Too much insulin, however, can also cause a perilous condition called hypoglycemia, which occurs when blood sugar levels drop too low. The thyroid is a close gland that produces thyroid hormone, which is essential for many aspects of the body's metabolism. Most of the time, grass roots with type 1 diabetes will develop an underactive thyroid, a state called Hashimoto's disease.
About 10 percent of the time the thyroid issue is an overactive thyroid, called Graves' disease. In general, subjects develop type 1 diabetes and then display thyroid problems at some point in the future, said Hatipoglu. However, with more commonalty being diagnosed with type 1 diabetes in their 30s, 40s and 50s it's quite doable that thyroid disease can come first.
People who have category 1 diabetes are more promising than others to develop an autoimmune thyroid condition. Though estimates vary, the gait of thyroid disease - either under- or overactive thyroid - may be as high as 30 percent in males and females with type 1 diabetes, according to Dr Betul Hatipoglu, an endocrinologist with the Cleveland Clinic in Ohio. And the likelihood are especially high for women, whether they have diabetes or not noting that women are eight times more like as not than men to develop thyroid disease.
And "I tell my patients thyroid infection and type 1 diabetes are sister diseases, like branches of a tree. Each is different, but the source is the same. And, that root is autoimmunity, where the immune system is attacking your own beneficial endocrine parts". Hatipoglu also noted that autoimmune diseases often run in families.
A grandparent may have had thyroid problems, while an heir may develop type 1 diabetes. "People who have one autoimmune blight are at risk for another," explained Dr Lowell Schmeltz, an endocrinologist and assistant professor at the Oakland University-William Beaumont School of Medicine in Royal Oak, Mich.
So "There's some genetic jeopardize that links these autoimmune conditions, but we don't separate what environmental triggers make them activate," he explained, adding that the antibodies from the invulnerable system that destroy the healthy tissue are different in type 1 diabetes than in autoimmune thyroid disease. Hatipoglu said that public with type 1 diabetes are also more tending to celiac disease, another autoimmune condition.
Type 1 diabetes occurs when the immune arrangement mistakenly attacks the insulin-producing cells in the pancreas, destroying them. Insulin is a hormone that's compelling for the metabolism of carbohydrates in foods. Without enough insulin, blood sugar levels can skyrocket, important to serious complications or death. People who have type 1 diabetes have to replace the frenzied insulin, using shots of insulin or an insulin pump with a tube inserted under the skin.
Too much insulin, however, can also cause a perilous condition called hypoglycemia, which occurs when blood sugar levels drop too low. The thyroid is a close gland that produces thyroid hormone, which is essential for many aspects of the body's metabolism. Most of the time, grass roots with type 1 diabetes will develop an underactive thyroid, a state called Hashimoto's disease.
About 10 percent of the time the thyroid issue is an overactive thyroid, called Graves' disease. In general, subjects develop type 1 diabetes and then display thyroid problems at some point in the future, said Hatipoglu. However, with more commonalty being diagnosed with type 1 diabetes in their 30s, 40s and 50s it's quite doable that thyroid disease can come first.
Saturday 1 March 2014
Acquired Leukoderma Linked To Immune System Dysfunction
Acquired Leukoderma Linked To Immune System Dysfunction.
Scientists have discovered several genes linked to acquired leukoderma (vitiligo) that verify the pelt condition is, indeed, an autoimmune disorder. Vitiligo is a pigmentation disturb that causes white splotches to appear on the skin; the at an advanced hour pop star Michael Jackson suffered from the condition. The finding could lead to treatments for this confounding condition, the University of Colorado researchers said.
So "If you can construe the pathway that leads to the putting to death of the skin cell, then you can block that pathway," reasoned Dr Doris Day, a dermatologist with Lenox Hill Hospital in New York City. More surprisingly, however, was an minor conception related to the deadly skin cancer melanoma: People with vitiligo are less likely to reveal melanoma and vice-versa.
But "That was absolutely unexpected," said Dr Richard A Spritz, contribute to author of a paper appearing in the April 21 online issue of the New England Journal of Medicine. This finding, too, could superintend to better treatments for this insidious skin cancer. Vitiligo, similarly to a collection of about 80 other diseases including rheumatoid arthritis, type 1 diabetes and lupus, was strongly suspected to be an autoimmune scuffle in which the body's own immune set-up attacks itself, in this case, the skin's melanocytes, or pigment-producing cells.
People with the disorder, which typically appears around the long time of 20 or 25, develop white patches on their skin. Vitiligo it is fairly common, affecting up to 2 percent of the population. But the mystery of whether or not vitiligo really is an autoimmune infection has been a controversial one, said Spritz, a professor in the Human Medical Genetics Program at the University of Colorado School of Medicine in Aurora.
At the urging of various sedulous groups, these authors conducted a genome-wide link study of more than 5,000 individuals, both with and without vitiligo. Several genes found to be linked with vitiligo also had associations with other autoimmune disorders, such as breed 1 diabetes and rheumatoid arthritis.
Scientists have discovered several genes linked to acquired leukoderma (vitiligo) that verify the pelt condition is, indeed, an autoimmune disorder. Vitiligo is a pigmentation disturb that causes white splotches to appear on the skin; the at an advanced hour pop star Michael Jackson suffered from the condition. The finding could lead to treatments for this confounding condition, the University of Colorado researchers said.
So "If you can construe the pathway that leads to the putting to death of the skin cell, then you can block that pathway," reasoned Dr Doris Day, a dermatologist with Lenox Hill Hospital in New York City. More surprisingly, however, was an minor conception related to the deadly skin cancer melanoma: People with vitiligo are less likely to reveal melanoma and vice-versa.
But "That was absolutely unexpected," said Dr Richard A Spritz, contribute to author of a paper appearing in the April 21 online issue of the New England Journal of Medicine. This finding, too, could superintend to better treatments for this insidious skin cancer. Vitiligo, similarly to a collection of about 80 other diseases including rheumatoid arthritis, type 1 diabetes and lupus, was strongly suspected to be an autoimmune scuffle in which the body's own immune set-up attacks itself, in this case, the skin's melanocytes, or pigment-producing cells.
People with the disorder, which typically appears around the long time of 20 or 25, develop white patches on their skin. Vitiligo it is fairly common, affecting up to 2 percent of the population. But the mystery of whether or not vitiligo really is an autoimmune infection has been a controversial one, said Spritz, a professor in the Human Medical Genetics Program at the University of Colorado School of Medicine in Aurora.
At the urging of various sedulous groups, these authors conducted a genome-wide link study of more than 5,000 individuals, both with and without vitiligo. Several genes found to be linked with vitiligo also had associations with other autoimmune disorders, such as breed 1 diabetes and rheumatoid arthritis.
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