Patients With Chronic Kidney Disease Should Reduce The Dose Of Medication For Anemia.
Doctors should use the anemia drugs Procrit, Epogen and Aranesp more cautiously in patients with long-lived kidney disease, US vigorousness officials said Friday. The redone notification comes in response to data showing that patients on these drugs encounter a higher risk of cardiovascular problems such as heart attack, heart failure, stroke, blood clots and death, the US Food and Drug Administration said. "FDA is recommending new, more temperate dosing recommendations for erythropoiesis-stimulating agents ESAs for patients with continuing kidney disease," Dr Robert C Kane, acting envoy director for safety in the division of hematology products, said during a story conference Friday.
These recommendations are being added to the drug label's shameful box warning and sections of the package inserts. This is not the first time health risks have been linked to these anemia drugs. They have also been tied to increased tumor excrescence in cancer patients and may cause some patients to want sooner.
Also, cancer patients have an increased risk of blood clots, mettle attack, heart failure and stroke, according to the FDA. Procrit, Epogen and Aranesp are synthetic versions of a sympathetic protein known as erythropoietin that prods bone marrow to produce red blood cells.
The drugs are typically cast-off to treat anemia in cancer patients and to reduce the need for numerous blood transfusions. Anemia also occurs in patients with chronic kidney disease. Anemia results from the body's incapability to produce enough red blood cells, which contain the hemoglobin needed to carry o a continue oxygen to the cells.
Currently, labels on these drugs say ESAs should be used to achieve and maintain hemoglobin levels within 10 to 12 grams per deciliter of blood in patients with persistent kidney disease. These aim levels will no longer be given on the label, the agency added. Hemoglobin levels greater than 11 grams per deciliter of blood increases the hazard of stroke, sincerity attack, heart failure and blood clots and haven't been proven to provide any additional forward to patients, according to the FDA.
Showing posts with label kidney. Show all posts
Showing posts with label kidney. Show all posts
Tuesday 18 February 2020
Saturday 9 December 2017
The Number Of End-Stage Renal Disease In Diabetic Patients Decreased By 35% Over The Past 10 Years
The Number Of End-Stage Renal Disease In Diabetic Patients Decreased By 35% Over The Past 10 Years.
The place of inexperienced cases of end-stage kidney affliction requiring dialysis among Americans diagnosed with diabetes flatten 35 percent between 1996 and 2007, a new study has found. The age-adjusted amount of end-stage kidney disease, also known as end-stage renal disease (ESRD), that was linked to diabetes declined from 304,5 to about 199 per 100000 tribe during that time. The declining rates occurred in all regions and in most states.
No condition had a significant increase in the age-adjusted rate of novel cases of the condition, the researchers report in the Oct 29, 2010 issue of the Morbidity and Mortality Weekly Report, published by the US Centers for Disease Control and Prevention. ESRD, which is kidney failing requiring dialysis or transplantation, is a costly and disabling inure that can lead to premature death. Diabetes is the outstanding cause of ESRD in the United States and accounted for 44 percent of the approximately 110000 cases that began healing in 2007.
The place of inexperienced cases of end-stage kidney affliction requiring dialysis among Americans diagnosed with diabetes flatten 35 percent between 1996 and 2007, a new study has found. The age-adjusted amount of end-stage kidney disease, also known as end-stage renal disease (ESRD), that was linked to diabetes declined from 304,5 to about 199 per 100000 tribe during that time. The declining rates occurred in all regions and in most states.
No condition had a significant increase in the age-adjusted rate of novel cases of the condition, the researchers report in the Oct 29, 2010 issue of the Morbidity and Mortality Weekly Report, published by the US Centers for Disease Control and Prevention. ESRD, which is kidney failing requiring dialysis or transplantation, is a costly and disabling inure that can lead to premature death. Diabetes is the outstanding cause of ESRD in the United States and accounted for 44 percent of the approximately 110000 cases that began healing in 2007.
Friday 1 December 2017
Common Medicines For Kidney Cancer Damage The Protein Structure
Common Medicines For Kidney Cancer Damage The Protein Structure.
The considerably employed cancer drug bevacizumab (Avastin) is associated with a more than fourfold increased endanger of severe urinary protein loss, a new review finds. This outstanding loss of protein from the kidney into the urine can lead to significant kidney damage and reduce the effectiveness of the cancer drug, imply the researchers, who are from Stony Brook University Cancer Center in New York. The findings, culled from an dissection of 16 studies involving more than 12000 cancer patients, suggest that doctors insufficiency to monitor the kidney health of patients being treated with bevacizumab.
The report was released online June 10 in contribute to of publication in an upcoming print issue of the Journal of the American Society of Nephrology. In the review, 2,2 percent of the patients taking Avastin proficient simple proteinura, with patients who were taking the highest doses of the drug facing an even higher risk. Also, the kidney of cancer played a role in the risk of kidney trouble, with kidney cancer patients since the greatest risk (10,2 percent).
The considerably employed cancer drug bevacizumab (Avastin) is associated with a more than fourfold increased endanger of severe urinary protein loss, a new review finds. This outstanding loss of protein from the kidney into the urine can lead to significant kidney damage and reduce the effectiveness of the cancer drug, imply the researchers, who are from Stony Brook University Cancer Center in New York. The findings, culled from an dissection of 16 studies involving more than 12000 cancer patients, suggest that doctors insufficiency to monitor the kidney health of patients being treated with bevacizumab.
The report was released online June 10 in contribute to of publication in an upcoming print issue of the Journal of the American Society of Nephrology. In the review, 2,2 percent of the patients taking Avastin proficient simple proteinura, with patients who were taking the highest doses of the drug facing an even higher risk. Also, the kidney of cancer played a role in the risk of kidney trouble, with kidney cancer patients since the greatest risk (10,2 percent).
Thursday 4 May 2017
Two New Tests To Determine The Future Of Patients With Diseased Kidneys
Two New Tests To Determine The Future Of Patients With Diseased Kidneys.
Researchers have come up with two late tests that seem better able to portend which patients with dyed in the wool kidney disease are more likely to progress to kidney failure and death. This could help streamline care, getting those patients who needfulness it most the care they need, while perhaps sparing other patients unnecessary interventions. "The reborn markers provide us with an opportunity to address kidney disease prior to its lethal stage," said Dr Ernesto P Molmenti, vice chairman of surgery and superintendent of the transplant program at the North Shore-Long Island Jewish Health System in Manhasset, NY - "Such initially treatment could provide for increased survival, as well as enhanced quality of life".
And "The paramount problem right now is the tests we use currently just are not very good at identifying people's progressing to either more advanced kidney malady or end-stage kidney disease, so this has big implications in trying to determine who will progress," said Dr Troy Plumb, interim ranking of nephrology at the University of Nebraska Medical Center in Omaha. But "there are growing to have to be validated clinical trials" before these new tests are introduced into clinical practice.
Both studies will appear in the April 20 daughter of the Journal of the American Medical Association, but were released Monday to co-occur with presentations at the World Congress of Nephrology, in Vancouver. Some 23 million commoners in the United States have chronic kidney disease, which can often progress to kidney flop (making dialysis or a transplant necessary), and even death. But experts have no really fit way to predict who will progress to more serious disease or when.
Right now, kidney function, or glomerular filtration count (GFR), is based on measuring blood levels of creatinine, a waste result that is normally removed from the body by the kidneys. The first set of study authors, from the San Francisco VA Medical Center, added two other measurements to the mix: GFR reasoned by cystatin C, a protein also eliminated from the body by the kidneys; and albuminuria, or too much protein in the urine.
Researchers have come up with two late tests that seem better able to portend which patients with dyed in the wool kidney disease are more likely to progress to kidney failure and death. This could help streamline care, getting those patients who needfulness it most the care they need, while perhaps sparing other patients unnecessary interventions. "The reborn markers provide us with an opportunity to address kidney disease prior to its lethal stage," said Dr Ernesto P Molmenti, vice chairman of surgery and superintendent of the transplant program at the North Shore-Long Island Jewish Health System in Manhasset, NY - "Such initially treatment could provide for increased survival, as well as enhanced quality of life".
And "The paramount problem right now is the tests we use currently just are not very good at identifying people's progressing to either more advanced kidney malady or end-stage kidney disease, so this has big implications in trying to determine who will progress," said Dr Troy Plumb, interim ranking of nephrology at the University of Nebraska Medical Center in Omaha. But "there are growing to have to be validated clinical trials" before these new tests are introduced into clinical practice.
Both studies will appear in the April 20 daughter of the Journal of the American Medical Association, but were released Monday to co-occur with presentations at the World Congress of Nephrology, in Vancouver. Some 23 million commoners in the United States have chronic kidney disease, which can often progress to kidney flop (making dialysis or a transplant necessary), and even death. But experts have no really fit way to predict who will progress to more serious disease or when.
Right now, kidney function, or glomerular filtration count (GFR), is based on measuring blood levels of creatinine, a waste result that is normally removed from the body by the kidneys. The first set of study authors, from the San Francisco VA Medical Center, added two other measurements to the mix: GFR reasoned by cystatin C, a protein also eliminated from the body by the kidneys; and albuminuria, or too much protein in the urine.
Saturday 24 September 2016
Results Of Kidney Transplantation In HIV-Infected Patients
Results Of Kidney Transplantation In HIV-Infected Patients.
A large, green investigation provides more evidence that people infected with HIV, the virus that causes AIDS, do almost as well on the survival towards as other patients when they undergo kidney transplants. Up until the mid-1990s, physicians tended to elude giving kidney transplants to HIV patients because of fear that AIDS would quickly kill them. Since then, untrained medications have greatly lengthened life spans for HIV patients, and surgeons routinely play kidney transplants on them in some urban hospitals.
The study authors, led by Dr Peter G Stock, a professor of surgery at the University of California, San Francisco, examined the medical records of 150 HIV-infected patients who underwent kidney transplantation between 2003 and 2009. They publish their findings in the Nov. 18 event of the New England Journal of Medicine.
The researchers found that about 95 percent of the uproot patients lived for one year and about 88 percent lived for three years. Those survival rates killed between those for kidney transfer patients in unspecialized and those who are aged 65 and over. "They live just as long as the other patients we consider for transplantation. They're essentially the same as the holder of our patients," said transplant specialist Dr Silas P Norman, an subordinate professor of internal medicine at the University of Michigan. Norman was not part of the meditate on team.
A large, green investigation provides more evidence that people infected with HIV, the virus that causes AIDS, do almost as well on the survival towards as other patients when they undergo kidney transplants. Up until the mid-1990s, physicians tended to elude giving kidney transplants to HIV patients because of fear that AIDS would quickly kill them. Since then, untrained medications have greatly lengthened life spans for HIV patients, and surgeons routinely play kidney transplants on them in some urban hospitals.
The study authors, led by Dr Peter G Stock, a professor of surgery at the University of California, San Francisco, examined the medical records of 150 HIV-infected patients who underwent kidney transplantation between 2003 and 2009. They publish their findings in the Nov. 18 event of the New England Journal of Medicine.
The researchers found that about 95 percent of the uproot patients lived for one year and about 88 percent lived for three years. Those survival rates killed between those for kidney transfer patients in unspecialized and those who are aged 65 and over. "They live just as long as the other patients we consider for transplantation. They're essentially the same as the holder of our patients," said transplant specialist Dr Silas P Norman, an subordinate professor of internal medicine at the University of Michigan. Norman was not part of the meditate on team.
Monday 18 April 2016
Body Weight Affects Kidney Disease
Body Weight Affects Kidney Disease.
Obesity increases the endanger of developing kidney disease, a budding study suggests. Moreover, declines in kidney function can be detected dream of before people develop other obesity-related diseases such as diabetes and high blood pressure, the researchers said in Dec, 2013. The researchers analyzed statistics collected from nearly 3000 swart and white young adults who had normal kidney function. The participants, who had an average life-span of 35, were grouped according to four ranges of body-mass index (BMI), a measurement of body fat based on extreme and weight.
The groups were normal weight, overweight, obese and extremely obese. Over time, kidney ceremony decreased in all the participants, but the decline was much greater and quicker in overweight and overweight people, and appeared to be linked solely with body-mass index. "When we accounted for diabetes, turned on blood pressure and inflammatory processes, body-mass index was still a predictor of kidney function decline," inspect first author Dr Vanessa Grubbs, an assistant adjunct professor of cure-all at the University of California, San Francisco, said in a university news release.
Obesity increases the endanger of developing kidney disease, a budding study suggests. Moreover, declines in kidney function can be detected dream of before people develop other obesity-related diseases such as diabetes and high blood pressure, the researchers said in Dec, 2013. The researchers analyzed statistics collected from nearly 3000 swart and white young adults who had normal kidney function. The participants, who had an average life-span of 35, were grouped according to four ranges of body-mass index (BMI), a measurement of body fat based on extreme and weight.
The groups were normal weight, overweight, obese and extremely obese. Over time, kidney ceremony decreased in all the participants, but the decline was much greater and quicker in overweight and overweight people, and appeared to be linked solely with body-mass index. "When we accounted for diabetes, turned on blood pressure and inflammatory processes, body-mass index was still a predictor of kidney function decline," inspect first author Dr Vanessa Grubbs, an assistant adjunct professor of cure-all at the University of California, San Francisco, said in a university news release.
Friday 15 April 2016
Dialysis Six Times A Week For Some Patients Better Than Three
Dialysis Six Times A Week For Some Patients Better Than Three.
Kidney collapse patients who treacherous the number of weekly dialysis treatments typically prescribed had significantly better determination function, overall health and general quality of life, new examination indicates. The finding stems from an analysis that compared the impact of the 40-year-old standard of punctiliousness - three dialysis treatments per week, for three to four hours per sitting - with a six-day a week treatment regimen involving sessions of 2,5 to three hours per session. Launched in 2006, the contrasting involved 245 dialysis patients assigned to either a pier dialysis schedule or the high-frequency option. All participants underwent MRIs to assess fundamentals muscle structure, and all completed quality-of-life surveys.
In addition to improved cardiovascular trim and overall health, the analysis further revealed that two concerns faced by most kidney failure patients - blood constraint and phosphate level control - also fared better under the more frequent healing program. Dr Glenn Chertow, chief of the nephrology division at Stanford University School of Medicine, reports his team's observations in the Nov 20, 2010 online print run of the New England Journal of Medicine, to equal with a presentation at the annual meeting of the American Society of Nephrology in Denver.
And "Kidneys handiwork seven days a week, 24 hours a day," Chertow famous in a Stanford University news release. "You could imagine why people might feel better if dialysis were to more closely feigned kidney function. But you have to factor in the burden of additional sessions, the associate and the cost".
Kidney collapse patients who treacherous the number of weekly dialysis treatments typically prescribed had significantly better determination function, overall health and general quality of life, new examination indicates. The finding stems from an analysis that compared the impact of the 40-year-old standard of punctiliousness - three dialysis treatments per week, for three to four hours per sitting - with a six-day a week treatment regimen involving sessions of 2,5 to three hours per session. Launched in 2006, the contrasting involved 245 dialysis patients assigned to either a pier dialysis schedule or the high-frequency option. All participants underwent MRIs to assess fundamentals muscle structure, and all completed quality-of-life surveys.
In addition to improved cardiovascular trim and overall health, the analysis further revealed that two concerns faced by most kidney failure patients - blood constraint and phosphate level control - also fared better under the more frequent healing program. Dr Glenn Chertow, chief of the nephrology division at Stanford University School of Medicine, reports his team's observations in the Nov 20, 2010 online print run of the New England Journal of Medicine, to equal with a presentation at the annual meeting of the American Society of Nephrology in Denver.
And "Kidneys handiwork seven days a week, 24 hours a day," Chertow famous in a Stanford University news release. "You could imagine why people might feel better if dialysis were to more closely feigned kidney function. But you have to factor in the burden of additional sessions, the associate and the cost".
Wednesday 31 July 2013
Dysfunction Of The Autonomic Nervous System May Be A Marker Of Later Development Of Certain Types Of Kidney Disease
Dysfunction Of The Autonomic Nervous System May Be A Marker Of Later Development Of Certain Types Of Kidney Disease.
A person's empathy spent may proposition discernment into their tomorrow kidney health, a new study suggests canada. A high-priced resting heart rate and low beat-to-beat quintessence rate variability were noted in study patients with an increased endanger for kidney disease, according to a report released online July 8 in go on of publication in an upcoming print issue of the Journal of the American Society of Nephrology.
The find suggests that dysfunction of the autonomic highly-strung system - which regulates involuntary body functions such as fundamentals rate, blood pressure, temperature and stress effect - may be a marker for late development of certain types of kidney disease, explained Dr Daniel Brotman of Johns Hopkins University School of Medicine and colleagues, in a information publicity release from the American Society of Nephrology. Previous studies have suggested a associate between autonomic troubled system dysfunction (dysautonomia) and chronic kidney condition and its progression.
A person's empathy spent may proposition discernment into their tomorrow kidney health, a new study suggests canada. A high-priced resting heart rate and low beat-to-beat quintessence rate variability were noted in study patients with an increased endanger for kidney disease, according to a report released online July 8 in go on of publication in an upcoming print issue of the Journal of the American Society of Nephrology.
The find suggests that dysfunction of the autonomic highly-strung system - which regulates involuntary body functions such as fundamentals rate, blood pressure, temperature and stress effect - may be a marker for late development of certain types of kidney disease, explained Dr Daniel Brotman of Johns Hopkins University School of Medicine and colleagues, in a information publicity release from the American Society of Nephrology. Previous studies have suggested a associate between autonomic troubled system dysfunction (dysautonomia) and chronic kidney condition and its progression.
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