Menopause Affects Women Differently.
Women bothered by blether flashes or other crap of menopause have a number of treatment options - hormonal or not, according to updated guidelines from the American College of Obstetricians and Gynecologists. It's estimated that anywhere from 50 percent to 82 percent of women effective through menopause have recent flashes - sudden feelings of extreme intensity in the upper body - and night sweats. For many, the symptoms are frequent and severe enough to cause repose problems and disrupt their daily lives.
And the duration of the misery can last from a couple years to more than a decade, says the college, the nation's influential group of ob/gyns. "Menopausal symptoms are common, and can be very bothersome to women," said Dr Clarisa Gracia, who helped put in writing the new guidelines. "Women should grasp that effective treatments are available to address these symptoms". The guidelines, published in the January outlet of Obstetrics andamp; Gynecology, reinforce some longstanding advice: Hormone therapy, with estrogen by oneself or estrogen plus progestin, is the most effective way to cool hot flashes.
But they also advance out the growing evidence that some antidepressants can help an associate professor of obstetrics and gynecology at the University of Pennsylvania in Philadelphia. In studies, down doses of antidepressants such as venlafaxine (Effexor) and fluoxetine (Prozac) have helped spell hot flashes in some women. And two other drugs - the anti-seizure cure gabapentin and the blood pressure medication clonidine - can be effective, according to the guidelines.
So far, though, only one non-hormonal anaesthetize is actually approved by the US Food and Drug Administration for treating brilliant flashes: a low-dose version of the antidepressant paroxetine (Paxil). And experts said that while there is manifest some hormone alternatives ease hot flashes, none works as well as estrogen and estrogen-progestin. "Unfortunately, many providers are white-livered to prescribe hormones.
And a lot of the time, women are fearful," said Dr Patricia Sulak, an ob/gyn at Scott andamp; White Hospital in Temple, Texas, who was not affected in calligraphy the new guidelines. Years ago, doctors routinely prescribed hormone replacement analysis after menopause to lower women's risk of heart disease, among other things. But in 2002, a colossal US trial called the Women's Health Initiative found that women given estrogen-progestin pills really had slightly increased risks of blood clots, heart attack and breast cancer. "Use of hormones plummeted" after that.
Saturday, 30 November 2019
Fibrosis Of The Heart Muscle Can Lead To Sudden Death
Fibrosis Of The Heart Muscle Can Lead To Sudden Death.
Scarring in the heart's impediment may be a indicator risk factor for death, and scans that reckon the amount of scarring might help in deciding which patients need particular treatments, a new turn over suggests. At issue is a kind of scarring, or fibrosis, known as midwall fibrosis. Reporting in the March 6 exit of the Journal of the American Medical Association, researchers found that patients with enlarged hearts who had more of this strain of damage were more than five times more likely to experience sudden cardiac extermination compared to patients without such scarring. "Both the presence of fibrosis and the extent were independently and incrementally associated with all-cause mortality passing ," concluded a team led by Dr Ankur Gulati of Royal Brompton Hospital, in London.
In the study, the researchers took high-tech MRI scans of the hearts of 472 patients with dilated cardiomyopathy, a material of weakened and enlarged goodness that is often linked to consideration failure. The MRIs looked for scarring in the middle section of the heart muscle wall. Tracking the patients for an normal of more than five years, the team reported that while about 11 percent of patients without midwall fibrosis had died, nearly 27 percent of those with such scarring had died.
According to Gulati's team, assessments of midwall scarring based on MRI imaging might be valuable to doctors in pinpointing which patients with enlarged hearts are at highest gamble for death, disorderly heart rhythms and heart failure. Experts in the United States agreed that gauging the dimensions of scarring on the heart provides worthwhile information. "The severity of the dysfunction can be linked to the extent with which healthy heart muscle is replaced by nonfunctioning dent tissue," explained Dr Moshe Gunsburg, director of the cardiac arrhythmia accommodation and co-chief of the division of cardiology at Brookdale University Hospital and Medical Center, in New York City.
Scarring in the heart's impediment may be a indicator risk factor for death, and scans that reckon the amount of scarring might help in deciding which patients need particular treatments, a new turn over suggests. At issue is a kind of scarring, or fibrosis, known as midwall fibrosis. Reporting in the March 6 exit of the Journal of the American Medical Association, researchers found that patients with enlarged hearts who had more of this strain of damage were more than five times more likely to experience sudden cardiac extermination compared to patients without such scarring. "Both the presence of fibrosis and the extent were independently and incrementally associated with all-cause mortality passing ," concluded a team led by Dr Ankur Gulati of Royal Brompton Hospital, in London.
In the study, the researchers took high-tech MRI scans of the hearts of 472 patients with dilated cardiomyopathy, a material of weakened and enlarged goodness that is often linked to consideration failure. The MRIs looked for scarring in the middle section of the heart muscle wall. Tracking the patients for an normal of more than five years, the team reported that while about 11 percent of patients without midwall fibrosis had died, nearly 27 percent of those with such scarring had died.
According to Gulati's team, assessments of midwall scarring based on MRI imaging might be valuable to doctors in pinpointing which patients with enlarged hearts are at highest gamble for death, disorderly heart rhythms and heart failure. Experts in the United States agreed that gauging the dimensions of scarring on the heart provides worthwhile information. "The severity of the dysfunction can be linked to the extent with which healthy heart muscle is replaced by nonfunctioning dent tissue," explained Dr Moshe Gunsburg, director of the cardiac arrhythmia accommodation and co-chief of the division of cardiology at Brookdale University Hospital and Medical Center, in New York City.
Thursday, 28 November 2019
Allergic To Penicillin May Not Apply To Related Antibiotics
Allergic To Penicillin May Not Apply To Related Antibiotics.
Most patients who have a antiquity of penicillin allergy can safely receive antibiotics called cephalosporins, researchers say. Cephalosporins - which are joint to penicillin in their structure, uses and effects - are the most c oftentimes prescribed class of antibiotics.
So "Almost all patients undergoing major surgery find out antibiotics to reduce the risk of infections. Many patients with a history of penicillin allergy don't get the cephalosporin because of a involvement of possible drug reaction.
They might get a second-choice antibiotic that is not quite as effective," boning up author Dr James T Li, of the Mayo Clinic in Rochester, Minn, said in a despatch release from the American Academy of Allergy, Asthma & Immunology. He and his colleagues conducted penicillin allergy decorticate tests on 178 patients who reported a history of unadorned allergic (anaphylactic) reaction to penicillin.
Most patients who have a antiquity of penicillin allergy can safely receive antibiotics called cephalosporins, researchers say. Cephalosporins - which are joint to penicillin in their structure, uses and effects - are the most c oftentimes prescribed class of antibiotics.
So "Almost all patients undergoing major surgery find out antibiotics to reduce the risk of infections. Many patients with a history of penicillin allergy don't get the cephalosporin because of a involvement of possible drug reaction.
They might get a second-choice antibiotic that is not quite as effective," boning up author Dr James T Li, of the Mayo Clinic in Rochester, Minn, said in a despatch release from the American Academy of Allergy, Asthma & Immunology. He and his colleagues conducted penicillin allergy decorticate tests on 178 patients who reported a history of unadorned allergic (anaphylactic) reaction to penicillin.
In Some Regions Of The US Patients Spend On Medicine Is Much More
In Some Regions Of The US Patients Spend On Medicine Is Much More.
Medicare patients in some regions of the United States allot significantly more on drugs than older folks abroad in the country, a reborn report finds. But higher downer spending doesn't mean they spend less on doctor visits or hospitalizations, the researchers say. "Our findings support the importance of understanding the drivers of geographic variation, since increases in medical spending or pharmaceutical spending do not appear to be associated with offsetting savings in the other realms," said potential researcher Yuting Zhang, an aide-de-camp professor of health economics at the University of Pittsburgh Graduate School of Public Health.
So "Spending on pharmaceuticals itself is unsteady and thus warrants scrutiny similar to that given to medical spending in rule to glean lessons about optimal prescribing, insurance characteristics, and resource allocation". The boom is published online June 9 in the New England Journal of Medicine.
For the study, Zhang's yoke looked at spending on drugs and other medical services among Medicare patients in 2007 at 306 hospital-referral regions across the country. "Widespread geographic variations exist, with some regions spending almost twice as much as others".
As party of their calculations, the researchers considered factors such as differences in costs, cover and overall robustness in the different geographic areas. Overall, drugs accounted for more than 20 percent of unconditional medical costs, but the researchers found substantial regional variations in drug spending.
Manhattan, in New York City, had the highest Medicare spending on drugs at $2973 per sufferer a year, while Hudson, Fla, had the lowest at $1854, the investigators found. Los Angeles, Montana, Alaska and Hawaii were other areas of heinous treatment spending by Medicare beneficiaries, while regions of down spending include parts of Arizona, New Mexico, Oregon and Maine, according to the report.
Medicare patients in some regions of the United States allot significantly more on drugs than older folks abroad in the country, a reborn report finds. But higher downer spending doesn't mean they spend less on doctor visits or hospitalizations, the researchers say. "Our findings support the importance of understanding the drivers of geographic variation, since increases in medical spending or pharmaceutical spending do not appear to be associated with offsetting savings in the other realms," said potential researcher Yuting Zhang, an aide-de-camp professor of health economics at the University of Pittsburgh Graduate School of Public Health.
So "Spending on pharmaceuticals itself is unsteady and thus warrants scrutiny similar to that given to medical spending in rule to glean lessons about optimal prescribing, insurance characteristics, and resource allocation". The boom is published online June 9 in the New England Journal of Medicine.
For the study, Zhang's yoke looked at spending on drugs and other medical services among Medicare patients in 2007 at 306 hospital-referral regions across the country. "Widespread geographic variations exist, with some regions spending almost twice as much as others".
As party of their calculations, the researchers considered factors such as differences in costs, cover and overall robustness in the different geographic areas. Overall, drugs accounted for more than 20 percent of unconditional medical costs, but the researchers found substantial regional variations in drug spending.
Manhattan, in New York City, had the highest Medicare spending on drugs at $2973 per sufferer a year, while Hudson, Fla, had the lowest at $1854, the investigators found. Los Angeles, Montana, Alaska and Hawaii were other areas of heinous treatment spending by Medicare beneficiaries, while regions of down spending include parts of Arizona, New Mexico, Oregon and Maine, according to the report.
Opioid Analgesics Are More Dangerous For Health Than The Non-Opioid Analgesics
Opioid Analgesics Are More Dangerous For Health Than The Non-Opioid Analgesics.
Two inexperienced studies suggest that Medicare patients who clutch opioid painkillers such as codeine, Vicodin or Oxycontin audacity higher health risks, including death, marrow problems or fractures, compared to those taking non-opioid analgesics. However, it's not clear if the painkillers are in a responsible for the differences in risk and other factors could play a role. And one pain specialist who's frequent with the findings said they don't reflect the experiences of doctors who've prescribed the drugs.
In one study, researchers examined a database of Medicare recipients in two states who were prescribed one of five kinds of opiod painkillers from 1996-2005. They looked at almost 6,300 patients who took one of these five painkillers: codeine phosphate, hydrocodone bitartrate (best known in its Vicodin form), oxycodone hydrochloride (Oxycontin), propoxyphene hydrochloride (Darvon), and tramadol hydrochloride (Ultram). Those who took codeine were 1,6 times more appropriate to have suffered from cardiovascular problems after 180 days, while patients on hydrocodone seemed to be at higher chance of fractures than those who took tramadol and propoxyphene.
After 30 days, those who took oxycodone were 2,4 times more proper to hanker than those taking hydrocodone, and codeine users were twice as fitting to die, although the add of deaths was small. The on authors caveat that their findings are surprising in some ways and needfulness to be confirmed by further research. Commenting on the study, Dr Russell K Portenoy, chairman of the section of pain medicine and palliative care at Beth Israel Medical Center in New York City, said that the findings are of circumscribed value because many other factors could spell out the differences between the drugs, such as how fast physicians ramped up the doses of patients.
Two inexperienced studies suggest that Medicare patients who clutch opioid painkillers such as codeine, Vicodin or Oxycontin audacity higher health risks, including death, marrow problems or fractures, compared to those taking non-opioid analgesics. However, it's not clear if the painkillers are in a responsible for the differences in risk and other factors could play a role. And one pain specialist who's frequent with the findings said they don't reflect the experiences of doctors who've prescribed the drugs.
In one study, researchers examined a database of Medicare recipients in two states who were prescribed one of five kinds of opiod painkillers from 1996-2005. They looked at almost 6,300 patients who took one of these five painkillers: codeine phosphate, hydrocodone bitartrate (best known in its Vicodin form), oxycodone hydrochloride (Oxycontin), propoxyphene hydrochloride (Darvon), and tramadol hydrochloride (Ultram). Those who took codeine were 1,6 times more appropriate to have suffered from cardiovascular problems after 180 days, while patients on hydrocodone seemed to be at higher chance of fractures than those who took tramadol and propoxyphene.
After 30 days, those who took oxycodone were 2,4 times more proper to hanker than those taking hydrocodone, and codeine users were twice as fitting to die, although the add of deaths was small. The on authors caveat that their findings are surprising in some ways and needfulness to be confirmed by further research. Commenting on the study, Dr Russell K Portenoy, chairman of the section of pain medicine and palliative care at Beth Israel Medical Center in New York City, said that the findings are of circumscribed value because many other factors could spell out the differences between the drugs, such as how fast physicians ramped up the doses of patients.
A New Approach To Liver Transplantation In Rats Is Making Progress
A New Approach To Liver Transplantation In Rats Is Making Progress.
A novel procedure to liver transplantation is making headway in overture work with rats, researchers say. Their work at the Center for Engineering in Medicine at Massachusetts General Hospital (MGH-CEM) could in the final point the way toward engineering fresh, functioning and transplantable liver organs out of discarded liver material, the researchers suggest. The research, reported online June 13 in Nature Medicine, is just at the "proof-of-concept" stage, but the group believes it has successfully fashioned a laboratory design to persuade stripped down structural liver tissue and essentially "reseed" it with newly introduced liver cells.
The ovum cells are then coaxed to adhere to the host scaffolding, so that they become and eventually re-establish the organ's complex vascular network. Although the highly complex ability is still far from the point at which it might be applicable to humans, the prospect is hopeful news for the liver transplant community. Because of a harsh shortage of donor organs, about 4000 Americans are deprived of potentially life-saving liver transplants each year.
A novel procedure to liver transplantation is making headway in overture work with rats, researchers say. Their work at the Center for Engineering in Medicine at Massachusetts General Hospital (MGH-CEM) could in the final point the way toward engineering fresh, functioning and transplantable liver organs out of discarded liver material, the researchers suggest. The research, reported online June 13 in Nature Medicine, is just at the "proof-of-concept" stage, but the group believes it has successfully fashioned a laboratory design to persuade stripped down structural liver tissue and essentially "reseed" it with newly introduced liver cells.
The ovum cells are then coaxed to adhere to the host scaffolding, so that they become and eventually re-establish the organ's complex vascular network. Although the highly complex ability is still far from the point at which it might be applicable to humans, the prospect is hopeful news for the liver transplant community. Because of a harsh shortage of donor organs, about 4000 Americans are deprived of potentially life-saving liver transplants each year.
New Method Of Treatment Glaucoma
New Method Of Treatment Glaucoma.
Contact lenses that direct glaucoma medication over elongate periods are getting closer to reality, say researchers working with laboratory animals. In their study, the lenses delivered the glaucoma knock out latanoprost (brand name Xalatan) continuously to animals for a month. It's hoped that some epoch such lenses will replace eye drops now occupied to treat the eye disease, the researchers said Dec 2013.
Contact lenses that direct glaucoma medication over elongate periods are getting closer to reality, say researchers working with laboratory animals. In their study, the lenses delivered the glaucoma knock out latanoprost (brand name Xalatan) continuously to animals for a month. It's hoped that some epoch such lenses will replace eye drops now occupied to treat the eye disease, the researchers said Dec 2013.
Wednesday, 27 November 2019
The Efficacy Of Antiseptic Soap
The Efficacy Of Antiseptic Soap.
The US Food and Drug Administration said Monday that it wants makers of antibacterial influence soaps and body washes to analyse their products are dependable for long-term daily use and more effective than regular soaps in preventing illness and the widening of certain infections. Unless companies can do that, they would have to reformulate or re-label these products if they want to keep them on the market, the activity said in Dec 2013. "Millions of Americans use antibacterial soaps and body washes," Dr Sandra Kweder, substitute director of the FDA's Office of New Drugs, Center for Drug Evaluation and Research, said during a matinal press briefing.
And "They are used every day at home, at work, at schools and in other social settings where the risk of bacterial infection is relatively low. We at the FDA find creditable there should be clearly demonstrated benefits from using antibacterial soaps to balance any potential risk". Kweder said the FDA has not been provided with statistics that shows these products are "any more effective at preventing family from getting sick than washing with plain soap and water".
The US Food and Drug Administration said Monday that it wants makers of antibacterial influence soaps and body washes to analyse their products are dependable for long-term daily use and more effective than regular soaps in preventing illness and the widening of certain infections. Unless companies can do that, they would have to reformulate or re-label these products if they want to keep them on the market, the activity said in Dec 2013. "Millions of Americans use antibacterial soaps and body washes," Dr Sandra Kweder, substitute director of the FDA's Office of New Drugs, Center for Drug Evaluation and Research, said during a matinal press briefing.
And "They are used every day at home, at work, at schools and in other social settings where the risk of bacterial infection is relatively low. We at the FDA find creditable there should be clearly demonstrated benefits from using antibacterial soaps to balance any potential risk". Kweder said the FDA has not been provided with statistics that shows these products are "any more effective at preventing family from getting sick than washing with plain soap and water".
Children Of The American Military Began A Thicket To Use Alcohol And Drugs
Children Of The American Military Began A Thicket To Use Alcohol And Drugs.
Children from naval families whose parents are deployed are at greater imperil for moonshine and drug use, according to a new study in April 2013. This danger increases when parents' deployment disrupts their children's living situation and the kids are forced to lodge with people who aren't relatives, researchers from the University of Iowa found. Schools should be aware that children from service families whose parents are deployed may need additional support, the researchers suggested. When at least one father is deployed, there is a measurable percentage of children who are not living with their natural parents," the study's older author, Stephan Arndt, professor of psychiatry in biostatistics, said in a university report release.
And "Some of these children go to live with a relative, but some go outside of the family, and that change in these children's living arrangements grossly distressed their risk of binge drinking and marijuana use". The results suggest that when a materfamilias deploys, it may be preferable to place a child with a family member and try to minimize the disruption. In 2010, nearly 2 million US children had at least one progenitrix on active military establishment duty, the researchers said.
The study, published online in the journal Addiction, involved poop compiled on nearly 60000 sixth-, eighth- and 11th-grade students who participated in the Iowa Youth Survey. The students answered questions online about their experiences with alcohol, drugs and violence.
Children from naval families whose parents are deployed are at greater imperil for moonshine and drug use, according to a new study in April 2013. This danger increases when parents' deployment disrupts their children's living situation and the kids are forced to lodge with people who aren't relatives, researchers from the University of Iowa found. Schools should be aware that children from service families whose parents are deployed may need additional support, the researchers suggested. When at least one father is deployed, there is a measurable percentage of children who are not living with their natural parents," the study's older author, Stephan Arndt, professor of psychiatry in biostatistics, said in a university report release.
And "Some of these children go to live with a relative, but some go outside of the family, and that change in these children's living arrangements grossly distressed their risk of binge drinking and marijuana use". The results suggest that when a materfamilias deploys, it may be preferable to place a child with a family member and try to minimize the disruption. In 2010, nearly 2 million US children had at least one progenitrix on active military establishment duty, the researchers said.
The study, published online in the journal Addiction, involved poop compiled on nearly 60000 sixth-, eighth- and 11th-grade students who participated in the Iowa Youth Survey. The students answered questions online about their experiences with alcohol, drugs and violence.
25 Percent Of Infants Suffer From Intestinal Colic
25 Percent Of Infants Suffer From Intestinal Colic.
Colic is a banal tough nut to crack for babies, and new research may finally provide clues to its cause: A niggardly study found that infants with colic seemed to develop certain intestinal bacteria later than those without the condition. What the researchers aren't direct on yet is why this would make some infants go on long crying jags each night for months. The study authors suspect that without the right balance of intestinal flora, the babies may know more pain and inflammation.
In particular, the study found differences in two types of bacteria. One is proteobacteria. The other is probiotics, which comprise bifidobacteria and lactobacilli. "Already in the first two weeks of life, limited significant differences between both groups were found. Proteobacteria were increased in infants with colic, with a more-than-doubled germane abundance.
These included specific species that are known to produce gas," said workroom author Carolina de Weerth, an associate professor of developmental psychology at Radboud University in Nijmegen, the Netherlands. "On the other hand, bifidobacteria and lactobacilli were increased in conduct infants. These included species that would set in motion anti-inflammatory effects. Moreover, samples from infants with colic were found to suppress fewer bacteria related to butyrate-producing species.
Butyrate is known to reduce pain in adults. These microbial signatures c explain the excessive crying". Results of the study appeared online Jan 14, 2013 and in the February picture issue of Pediatrics. Colic affects up to 25 percent of infants, De Weerth said. It is defined as crying for an unexceptional of more than three hours a day, in a general way between birth and 3 months of age, according to background dope in the study.
Little is known about what causes colic, and the only definitive cure for colic is time. The outrageous crying usually stops at around 4 months of age, according to the study. "Newborn crying is totally variable, and between 2 weeks and 8 or 10 weeks you can expect at least an hour of crying in a day. There may be some who whine less; some who cry more.
But, babies with colic really do watchword for three to four hours a day," said Dr Michael Hobaugh, chief of medical caduceus at La Rabida Children's Hospital, in Chicago. In the current study, the researchers tested more than 200 fecal samples from 12 infants with colic and 12 infants with obscene levels of crying (the guide group). Colic was determined at 6 weeks of age.
Colic is a banal tough nut to crack for babies, and new research may finally provide clues to its cause: A niggardly study found that infants with colic seemed to develop certain intestinal bacteria later than those without the condition. What the researchers aren't direct on yet is why this would make some infants go on long crying jags each night for months. The study authors suspect that without the right balance of intestinal flora, the babies may know more pain and inflammation.
In particular, the study found differences in two types of bacteria. One is proteobacteria. The other is probiotics, which comprise bifidobacteria and lactobacilli. "Already in the first two weeks of life, limited significant differences between both groups were found. Proteobacteria were increased in infants with colic, with a more-than-doubled germane abundance.
These included specific species that are known to produce gas," said workroom author Carolina de Weerth, an associate professor of developmental psychology at Radboud University in Nijmegen, the Netherlands. "On the other hand, bifidobacteria and lactobacilli were increased in conduct infants. These included species that would set in motion anti-inflammatory effects. Moreover, samples from infants with colic were found to suppress fewer bacteria related to butyrate-producing species.
Butyrate is known to reduce pain in adults. These microbial signatures c explain the excessive crying". Results of the study appeared online Jan 14, 2013 and in the February picture issue of Pediatrics. Colic affects up to 25 percent of infants, De Weerth said. It is defined as crying for an unexceptional of more than three hours a day, in a general way between birth and 3 months of age, according to background dope in the study.
Little is known about what causes colic, and the only definitive cure for colic is time. The outrageous crying usually stops at around 4 months of age, according to the study. "Newborn crying is totally variable, and between 2 weeks and 8 or 10 weeks you can expect at least an hour of crying in a day. There may be some who whine less; some who cry more.
But, babies with colic really do watchword for three to four hours a day," said Dr Michael Hobaugh, chief of medical caduceus at La Rabida Children's Hospital, in Chicago. In the current study, the researchers tested more than 200 fecal samples from 12 infants with colic and 12 infants with obscene levels of crying (the guide group). Colic was determined at 6 weeks of age.
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