Testing A New Experimental Drug To Raise Good Cholesterol Level.
An conjectural poison that raises HDL, or "good," cholesterol seems to have passed an sign hurdle by proving safe in preliminary trials. Although the trial was primarily designed to overlook at safety, researchers scheduled to present the finding Wednesday at the American Heart Association's annual assignation in Chicago also report that anacetrapib raised HDL cholesterol by 138 percent and slap in the face LDL, HDL's evil twin, almost in half. "We saw very encouraging reductions in clinical events," said Dr Christopher Cannon, assume command author of the study, which also appears in the Nov 18, 2010 exit of the New England Journal of Medicine.
A big study to seal the results would take four to five years to complete so the drug is still years away from market who is a cardiologist with Brigham and Women's Hospital in Boston. Other experts are intrigued by the findings, but note that the check out is still in very ahead stages. "There are a lot of people in the prevention/lipid field that are simultaneously excited and leery," said Dr Howard Weintraub, clinical concert-master of the Center for the Prevention of Cardiovascular Disease at NYU Langone Medical Center in New York City.
Added Dr John C LaRosa, president of the State University of New York (SUNY) Downstate Medical Center in New York City: "It's very prodromic but it's material because the final drug out of the barrel of this type was not a success. This looks match a better drug, but it's not definitive by any means. Don't take this to the bank".
LaRosa was referring to torcetrapib, which, get off on anacetrapib, belongs to the class of drugs known as cholesterol ester take protein (CETP) inhibitors. A large trial on torcetrapib was killed after investigators found an increased jeopardy of death and other cardiovascular outcomes. "I would be more excited about anacetrapib if I hadn't seen what happened to its cousin torcetrapib. Torcetrapib raised HDL astoundingly but that was completely neutralized by the development in cardiovascular events".
Showing posts with label cholesterol. Show all posts
Showing posts with label cholesterol. Show all posts
Tuesday 7 January 2020
Tuesday 3 December 2019
Overweight Often Leads To An Increase In Cholesterol And Diabetes
Overweight Often Leads To An Increase In Cholesterol And Diabetes.
Advances in medical method have made it easier than ever to trim dangerous cholesterol levels. A grade of cholesterol-lowering drugs known as statins have proven particularly effective, reducing the endanger for heart-related death by as much as 40 percent in people who have already suffered a heart attack, said Dr Vincent Bufalino, president and leading executive of Midwest Heart Specialists and a spokesman for the American Heart Association. "People have said we extremity them in the drinking water because they are just so effective in lowering cholesterol".
But he and other doctors on guard that when it comes to controlling cholesterol and enjoying overall health, nothing beats lifestyle changes, such as a heart-friendly victuals and regular exercise. "Once we became a fast-food generation, it's just too serene to order it at the first window, pick it up at the second window and eat it on the way to soccer. We paucity to get you to change now or you're going to end up as one of these statistics".
Folks with high cholesterol often are overweight, and if they deal with their cholesterol through medication only, they depart themselves open to such other chronic health problems as diabetes, high blood urge and arthritis, said Alice Lichtenstein, director and senior scientist at the Cardiovascular Nutrition Laboratory of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Medford, Mass. The design of controlling cholesterol solely through medication is "an wretched implication of view".
And "There are a lot of other factors, especially when it comes to body weight, that the medications won't help. The aim that 'I'll just take medications' isn't a very healthy option, especially for the long term". That spike of view seems to be bolstered by new evidence that using cholesterol-lowering drugs won't by definition help a person who hopes to avoid heart disease.
British researchers who pooled and re-analyzed evidence from 11 cardiovascular studies found that taking statins did not reduce cardiac deaths among people who had not developed callousness disease. The finding has been questioned, however, by some medical experts, who note that the research did secure an overall reduction in cholesterol levels linked to statin use. "I have to tell you that belies a lot of the other science," Bufalino said of the study.
High cholesterol is strongly connected to cardiovascular disease, which is the supreme cause of ruin in the United States, according to the American Heart Association. Nearly 2300 Americans die of cardiovascular cancer each day - an average of one death every 38 seconds.
Cholesterol, which is a waxy substance, occurs to be sure in the human body. In fact, the body produces about 75 percent of the cholesterol needed to execute important tasks, which include building cell walls, creating hormones, processing vitamin D and producing bile acids that tolerate fats, according to the US National Institutes of Health.
Advances in medical method have made it easier than ever to trim dangerous cholesterol levels. A grade of cholesterol-lowering drugs known as statins have proven particularly effective, reducing the endanger for heart-related death by as much as 40 percent in people who have already suffered a heart attack, said Dr Vincent Bufalino, president and leading executive of Midwest Heart Specialists and a spokesman for the American Heart Association. "People have said we extremity them in the drinking water because they are just so effective in lowering cholesterol".
But he and other doctors on guard that when it comes to controlling cholesterol and enjoying overall health, nothing beats lifestyle changes, such as a heart-friendly victuals and regular exercise. "Once we became a fast-food generation, it's just too serene to order it at the first window, pick it up at the second window and eat it on the way to soccer. We paucity to get you to change now or you're going to end up as one of these statistics".
Folks with high cholesterol often are overweight, and if they deal with their cholesterol through medication only, they depart themselves open to such other chronic health problems as diabetes, high blood urge and arthritis, said Alice Lichtenstein, director and senior scientist at the Cardiovascular Nutrition Laboratory of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Medford, Mass. The design of controlling cholesterol solely through medication is "an wretched implication of view".
And "There are a lot of other factors, especially when it comes to body weight, that the medications won't help. The aim that 'I'll just take medications' isn't a very healthy option, especially for the long term". That spike of view seems to be bolstered by new evidence that using cholesterol-lowering drugs won't by definition help a person who hopes to avoid heart disease.
British researchers who pooled and re-analyzed evidence from 11 cardiovascular studies found that taking statins did not reduce cardiac deaths among people who had not developed callousness disease. The finding has been questioned, however, by some medical experts, who note that the research did secure an overall reduction in cholesterol levels linked to statin use. "I have to tell you that belies a lot of the other science," Bufalino said of the study.
High cholesterol is strongly connected to cardiovascular disease, which is the supreme cause of ruin in the United States, according to the American Heart Association. Nearly 2300 Americans die of cardiovascular cancer each day - an average of one death every 38 seconds.
Cholesterol, which is a waxy substance, occurs to be sure in the human body. In fact, the body produces about 75 percent of the cholesterol needed to execute important tasks, which include building cell walls, creating hormones, processing vitamin D and producing bile acids that tolerate fats, according to the US National Institutes of Health.
Thursday 30 November 2017
Nuts, Seeds, Avocado And Sunflower Oil, Canola Oil, Olive Oil In A Low-Cholesterol Diet
Nuts, Seeds, Avocado And Sunflower Oil, Canola Oil, Olive Oil In A Low-Cholesterol Diet.
The attainment of a low-cholesterol regime can be improved by adding monounsaturated well-fed (MUFA), which are commonly found in nuts, seeds, avocados, and oils such as olive oil, canola lubricator and sunflower oil, new research suggests. In the study, researchers randomly assigned 17 men and seven postmenopausal women with passive to centre elevated cholesterol levels to either a high-MUFA diet or a low-MUFA diet.
Both groups consumed a vegetarian slim that included oats, barley, psyllium, eggplant, okra, soy, almonds and a position sterol-enriched margarine. In the high-MUFA group, the researchers substituted 13 percent of calories from carbohydrates with a high-MUFA sunflower oil, with the privilege of a partial exchange with avocado oil.
The attainment of a low-cholesterol regime can be improved by adding monounsaturated well-fed (MUFA), which are commonly found in nuts, seeds, avocados, and oils such as olive oil, canola lubricator and sunflower oil, new research suggests. In the study, researchers randomly assigned 17 men and seven postmenopausal women with passive to centre elevated cholesterol levels to either a high-MUFA diet or a low-MUFA diet.
Both groups consumed a vegetarian slim that included oats, barley, psyllium, eggplant, okra, soy, almonds and a position sterol-enriched margarine. In the high-MUFA group, the researchers substituted 13 percent of calories from carbohydrates with a high-MUFA sunflower oil, with the privilege of a partial exchange with avocado oil.
Thursday 27 July 2017
High Levels Of Blood HDL Cholesterol Protects Against Heart Disease And Reduces The Risk Of Cancer
High Levels Of Blood HDL Cholesterol Protects Against Heart Disease And Reduces The Risk Of Cancer.
Higher blood levels of HDL cholesterol, the "good" class that protects against boldness disease, are also strongly associated with a earlier jeopardy of cancer, a new review of studies suggests. "For about a 10-point increase of HDL, there is a reduced jeopardize of cancer by about one third over an average follow-up of 4,5 years," said Dr Richard Karas, government director of the Tufts Medical Center Molecular Cardiology Research Institute and wire author of a report in the June 22 issue of the Journal of the American College of Cardiology. Those numbers come from an investigation of 24 randomized controlled trials, aimed at determining the impact on heart disease of lowering levels of "bad" LDL cholesterol, through the use of statin drugs.
The rehash singled out trials that also recorded the incidence of cancer among the participants. The researchers backfire a 36 percent lower cancer rate for every 10 milligrams per liter (mg/dl) higher straight of HDL. But while the relationship between higher HDL and lower cancer hazard was independent of other cancer risk factors, such as smoking, obesity and age, Karas was precise to say the study does not prove cause and effect.
So "We can say that higher levels of HDL are associated with a move risk of cancer, but we can't say that one causes the other". Exactly so, said Dr Jennifer Robinson, professor of epidemiology and remedy at the University of Iowa College of Public Health, who wrote an accompanying editorial. High HDL levels may totally be a marker of the description of good traits that reduce both cardiovascular and cancer risk.
Higher blood levels of HDL cholesterol, the "good" class that protects against boldness disease, are also strongly associated with a earlier jeopardy of cancer, a new review of studies suggests. "For about a 10-point increase of HDL, there is a reduced jeopardize of cancer by about one third over an average follow-up of 4,5 years," said Dr Richard Karas, government director of the Tufts Medical Center Molecular Cardiology Research Institute and wire author of a report in the June 22 issue of the Journal of the American College of Cardiology. Those numbers come from an investigation of 24 randomized controlled trials, aimed at determining the impact on heart disease of lowering levels of "bad" LDL cholesterol, through the use of statin drugs.
The rehash singled out trials that also recorded the incidence of cancer among the participants. The researchers backfire a 36 percent lower cancer rate for every 10 milligrams per liter (mg/dl) higher straight of HDL. But while the relationship between higher HDL and lower cancer hazard was independent of other cancer risk factors, such as smoking, obesity and age, Karas was precise to say the study does not prove cause and effect.
So "We can say that higher levels of HDL are associated with a move risk of cancer, but we can't say that one causes the other". Exactly so, said Dr Jennifer Robinson, professor of epidemiology and remedy at the University of Iowa College of Public Health, who wrote an accompanying editorial. High HDL levels may totally be a marker of the description of good traits that reduce both cardiovascular and cancer risk.
Thursday 2 March 2017
Good Health Of The Heart Protects Against Alzheimer's Disease
Good Health Of The Heart Protects Against Alzheimer's Disease.
Sticking to a heart-healthy lifestyle may also quarter off Alzheimer's disease, according to a late study that suggests that raising "good" cholesterol levels can helper prevent the brain disorder in older people. The study, published in the December edition of Archives of Neurology, found that people who had low levels of high-density lipoprotein (HDL) or "good" cholesterol had a 60 percent greater endanger of developing Alzheimer's blight after the age of 65 than those who had high levels. Cholesterol is a waxy substance composed of "good and bad" cholesterol and triglycerides found in the bloodstream.
More than 50 percent of the US citizens has high levels of "bad" cholesterol, according to the study. "Our memorize suggests that high HDL levels 'good' cholesterol are associated with a decrease risk for Alzheimer's disease," said Dr Christiane Reitz, the study's author. "Ways to enhancement HDL levels include losing weight if overweight, aerobic irritate and a healthy diet".
By treating problems with cholesterol levels, "we can debase the incidence of Alzheimer's disease in the population". Some medications, such as statins, fibrates and niacin, that are in use to lower "bad" cholesterol also raise "good" cholesterol an assistant professor of neurology at Columbia University's Taub Institute for Research on Alzheimer's Disease in New York City. More than 5 million Americans have Alzheimer's disease, the most banal ceremony of dementia, and those numbers could triple by 2050, according to vigorousness officials.
The US National Institutes of Health reports that about 5 percent of Americans between the ages of 65 and 74 have late-onset Alzheimer's disease, the more commonplace form of the disorder, and the control increases with age. By age 85, nearly 50 percent of the population develops the disease, according to the agency.
Early-onset Alzheimer's, a excellent form of the disease, begins in middle age and runs in families. Late-onset Alzheimer's has a genetic component influenced by lifestyle factors, according to the agency. There is no prescription for Alzheimer's disease, but a few drugs can hand reduce symptoms for a time, according to experts.
Sticking to a heart-healthy lifestyle may also quarter off Alzheimer's disease, according to a late study that suggests that raising "good" cholesterol levels can helper prevent the brain disorder in older people. The study, published in the December edition of Archives of Neurology, found that people who had low levels of high-density lipoprotein (HDL) or "good" cholesterol had a 60 percent greater endanger of developing Alzheimer's blight after the age of 65 than those who had high levels. Cholesterol is a waxy substance composed of "good and bad" cholesterol and triglycerides found in the bloodstream.
More than 50 percent of the US citizens has high levels of "bad" cholesterol, according to the study. "Our memorize suggests that high HDL levels 'good' cholesterol are associated with a decrease risk for Alzheimer's disease," said Dr Christiane Reitz, the study's author. "Ways to enhancement HDL levels include losing weight if overweight, aerobic irritate and a healthy diet".
By treating problems with cholesterol levels, "we can debase the incidence of Alzheimer's disease in the population". Some medications, such as statins, fibrates and niacin, that are in use to lower "bad" cholesterol also raise "good" cholesterol an assistant professor of neurology at Columbia University's Taub Institute for Research on Alzheimer's Disease in New York City. More than 5 million Americans have Alzheimer's disease, the most banal ceremony of dementia, and those numbers could triple by 2050, according to vigorousness officials.
The US National Institutes of Health reports that about 5 percent of Americans between the ages of 65 and 74 have late-onset Alzheimer's disease, the more commonplace form of the disorder, and the control increases with age. By age 85, nearly 50 percent of the population develops the disease, according to the agency.
Early-onset Alzheimer's, a excellent form of the disease, begins in middle age and runs in families. Late-onset Alzheimer's has a genetic component influenced by lifestyle factors, according to the agency. There is no prescription for Alzheimer's disease, but a few drugs can hand reduce symptoms for a time, according to experts.
Tuesday 10 May 2016
Use Of Cholesterol Drugs By Patients Without High Cholesterol Level
Use Of Cholesterol Drugs By Patients Without High Cholesterol Level.
When the US Food and Drug Administration in February 2010 approved the use of the cholesterol-lowering statin remedy Crestor for some populace with regular cholesterol levels, cardiologist Dr Steven E Nissen cheered the decision. "You have to go with the ordered evidence," said Nissen, who is chairman of cardiovascular pharmaceutical at the Cleveland Clinic. "A clinical trial was done and there was a substantial reduction in morbidity and mortality in clan treated with this drug".
But Dr Mark A Hlatky, a professor of condition research and policy and medicine at Stanford University, has expressed doubts about the FDA move. He worries that more citizenry will rely on a pill rather than diet and exercise to cut their heart risk, and also points to studies linking statins such as Crestor to muscle troubles and even diabetes. "I haven't seen anything that changes my take offence at about that".
So, will millions of fine fettle Americans soon join the millions of less-than-healthy society who already take these blockbuster drugs? The FDA's Feb 9 approval of expanded use of rosuvastatin (Crestor) was based on results of the JUPITER study, which affected more than 18000 people and was financed by the drug's maker, AstraZeneca. People in the distress who took the drug for an average of 1,9 years had a 44 percent further risk of heart attack, stroke and other cardiovascular problems compared to those who took a placebo - results so choice that the trial was cut short. Based on JUPITER, an FDA warning committee voted 12 to 4 in December to approve widened use of the drug.
The ancestors in the trial included men over 50 and women over 60 with normal or near-normal cholesterol levels. However, these individuals did have exorbitant levels of C-reactive protein, a marker of inflammation that has also been linked to cardiovascular problems. They also had at least one other nerve risk factor, such as obesity or high blood pressure.
For that definite group, Crestor makes sense. "Over a five-year period of time, you abort one death or minor stroke for every 25 people treated". Whether or not others with normal cholesterol should fasten on Crestor or another statin remains unclear. "Not everyone with normal cholesterol should be treated. You should give it to multitude with a high enough risk".
When the US Food and Drug Administration in February 2010 approved the use of the cholesterol-lowering statin remedy Crestor for some populace with regular cholesterol levels, cardiologist Dr Steven E Nissen cheered the decision. "You have to go with the ordered evidence," said Nissen, who is chairman of cardiovascular pharmaceutical at the Cleveland Clinic. "A clinical trial was done and there was a substantial reduction in morbidity and mortality in clan treated with this drug".
But Dr Mark A Hlatky, a professor of condition research and policy and medicine at Stanford University, has expressed doubts about the FDA move. He worries that more citizenry will rely on a pill rather than diet and exercise to cut their heart risk, and also points to studies linking statins such as Crestor to muscle troubles and even diabetes. "I haven't seen anything that changes my take offence at about that".
So, will millions of fine fettle Americans soon join the millions of less-than-healthy society who already take these blockbuster drugs? The FDA's Feb 9 approval of expanded use of rosuvastatin (Crestor) was based on results of the JUPITER study, which affected more than 18000 people and was financed by the drug's maker, AstraZeneca. People in the distress who took the drug for an average of 1,9 years had a 44 percent further risk of heart attack, stroke and other cardiovascular problems compared to those who took a placebo - results so choice that the trial was cut short. Based on JUPITER, an FDA warning committee voted 12 to 4 in December to approve widened use of the drug.
The ancestors in the trial included men over 50 and women over 60 with normal or near-normal cholesterol levels. However, these individuals did have exorbitant levels of C-reactive protein, a marker of inflammation that has also been linked to cardiovascular problems. They also had at least one other nerve risk factor, such as obesity or high blood pressure.
For that definite group, Crestor makes sense. "Over a five-year period of time, you abort one death or minor stroke for every 25 people treated". Whether or not others with normal cholesterol should fasten on Crestor or another statin remains unclear. "Not everyone with normal cholesterol should be treated. You should give it to multitude with a high enough risk".
Wednesday 12 March 2014
Doctors Recommend Control Cholesterol Levels
Doctors Recommend Control Cholesterol Levels.
Keeping "bad" cholesterol in verify and increasing "good" cholesterol is not only rectitude for your heart, but also your brain, new research suggests. A meditate on from the University of California, Davis, found that low levels of "bad" (LDL) cholesterol and excited levels of "good" (HDL) cholesterol are linked to lower levels of so-called amyloid brooch in the brain. A build-up of this plaque is an indication of Alzheimer's disease, the researchers said in a university info release.
The researchers suggested that maintaining healthy cholesterol levels is just as important for intellect health as controlling blood pressure. "Our study shows that both higher levels of HDL and humiliate levels of LDL cholesterol in the bloodstream are associated with lower levels of amyloid plaquette deposits in the brain," the study's lead author, Bruce Reed, associate director of the UC Davis Alzheimer's Disease Center, said in the copy release. "Unhealthy patterns of cholesterol could be exactly causing the higher levels of amyloid known to contribute to Alzheimer's, in the same way that such patterns espouse heart disease," Reed said.
The study, which was published in the Dec 30, 2013 online number of the journal JAMA Neurology, involved 74 men and women recruited from California flourish clinics, support groups, senior-citizen facilities and the UC Davis Alzheimer's Disease Center. All of the participants were ancient 70 or older. Of this group, three multitude had mild dementia, 33 had no problems with brain function and 38 had mild lessening of their brain function.
Keeping "bad" cholesterol in verify and increasing "good" cholesterol is not only rectitude for your heart, but also your brain, new research suggests. A meditate on from the University of California, Davis, found that low levels of "bad" (LDL) cholesterol and excited levels of "good" (HDL) cholesterol are linked to lower levels of so-called amyloid brooch in the brain. A build-up of this plaque is an indication of Alzheimer's disease, the researchers said in a university info release.
The researchers suggested that maintaining healthy cholesterol levels is just as important for intellect health as controlling blood pressure. "Our study shows that both higher levels of HDL and humiliate levels of LDL cholesterol in the bloodstream are associated with lower levels of amyloid plaquette deposits in the brain," the study's lead author, Bruce Reed, associate director of the UC Davis Alzheimer's Disease Center, said in the copy release. "Unhealthy patterns of cholesterol could be exactly causing the higher levels of amyloid known to contribute to Alzheimer's, in the same way that such patterns espouse heart disease," Reed said.
The study, which was published in the Dec 30, 2013 online number of the journal JAMA Neurology, involved 74 men and women recruited from California flourish clinics, support groups, senior-citizen facilities and the UC Davis Alzheimer's Disease Center. All of the participants were ancient 70 or older. Of this group, three multitude had mild dementia, 33 had no problems with brain function and 38 had mild lessening of their brain function.
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