Some Antiepileptic Drugs During Pregnancy Can Have A Negative Impact On The Development Of The CNS Of The Teens

Some Antiepileptic Drugs During Pregnancy Can Have A Negative Impact On The Development Of The CNS Of The Teens.
Teens born to women who took two or more epilepsy drugs while club fared worse in sect than peers with no prenatal outlook to those medications, a extensive Swedish study has found. Also, teens born to epileptic mothers in inclusive tended to score lower in several subjects, including math and English. The findings stand by earlier research that linked prenatal endangerment to epilepsy drugs, particularly valproic acid (brand names include Depakene and Depakote), to anti effects on a child's ability to process information, solve problems and make decisions.

And "Our results suggest that imperilment to several anti-epileptic drugs in utero may have a negative effect on a child's neurodevelopment," said about author Dr Lisa Forsberg of Karolinska University Hospital. The mug up was published online Nov 4, 2010 in Epilepsia.

The study was retrospective, substance that it looked backwards in time. Using national medical records and a study conducted by a resident hospital, Forsberg and her team identified women with epilepsy who gave birth between 1973 and 1986, as well as those who cast-off anti-epileptic drugs during pregnancy. The team then obtained records of children's school play from a registry that provides grades for all students leaving school at 16, the age that mandatory schooling ends in Sweden.

The researchers identified 1,235 children born to epileptic mothers. Of those, 641 children were exposed to one anti-epileptic sedative and 429 to two or more; 165 children had no known peril to the medications. The researchers then compared those children's school doing to that of all other children born in Sweden (more than 1,3 million) during that 13-year period.

The teens exposed to more than one anti-epileptic medicament in the womb were less likely to get a final grade than those in the general population, said Forsberg. Not receiving a ultimate grade generally means not attending general school because of mental deficits.