Some Antiepileptic Drugs During Pregnancy Can Have A Negative Impact On The Development Of The CNS Of The Teens.
Teens born to women who took two or more epilepsy drugs while club fared worse in sect than peers with no prenatal outlook to those medications, a extensive Swedish study has found. Also, teens born to epileptic mothers in inclusive tended to score lower in several subjects, including math and English. The findings stand by earlier research that linked prenatal endangerment to epilepsy drugs, particularly valproic acid (brand names include Depakene and Depakote), to anti effects on a child's ability to process information, solve problems and make decisions.
And "Our results suggest that imperilment to several anti-epileptic drugs in utero may have a negative effect on a child's neurodevelopment," said about author Dr Lisa Forsberg of Karolinska University Hospital. The mug up was published online Nov 4, 2010 in Epilepsia.
The study was retrospective, substance that it looked backwards in time. Using national medical records and a study conducted by a resident hospital, Forsberg and her team identified women with epilepsy who gave birth between 1973 and 1986, as well as those who cast-off anti-epileptic drugs during pregnancy. The team then obtained records of children's school play from a registry that provides grades for all students leaving school at 16, the age that mandatory schooling ends in Sweden.
The researchers identified 1,235 children born to epileptic mothers. Of those, 641 children were exposed to one anti-epileptic sedative and 429 to two or more; 165 children had no known peril to the medications. The researchers then compared those children's school doing to that of all other children born in Sweden (more than 1,3 million) during that 13-year period.
The teens exposed to more than one anti-epileptic medicament in the womb were less likely to get a final grade than those in the general population, said Forsberg. Not receiving a ultimate grade generally means not attending general school because of mental deficits.
Showing posts with label epileptic. Show all posts
Showing posts with label epileptic. Show all posts
Tuesday 10 December 2019
Saturday 17 August 2013
Use Of Medicines For Epilepsy During Pregnancy Can Cause A Risk To The Child.
Pregnant women with epilepsy who are compelling carbamazepine (Tegretol) to device seizures may be at a minor extent increased hazard of having an infant with spina bifida, a further study finds. Spina bifida is a get in which the bones of the spine do not close but the spinal line remains in place, usually with skin covering the defect skin care with peptides. Most children will stress lifelong treatment for problems arising from devastation to the spinal cord and spinal nerves.
And "For women with epilepsy, paroxysm control during pregnancy is very important," said pass researcher Lolkje de Jong-van den Berg, from the borderline of pharmacy at the University of Groningen in the Netherlands. "Our weigh can help in decisions regarding whether carbamazepine should be the drug of superior in pregnancy". However, the best option regarding treatment can be chosen only on an personal basis by the woman and her neurologist before pregnancy, weighing the benefits of epilepsy put down against the risk of birth defects, de Jong-van den Berg said.
The write-up is published in the Dec 3, 2010 online number of the BMJ. For the study, de Jong-van den Berg's duo reviewed existing fact-finding to determine the risk of birth defects among women fetching Tegretol. The researchers found that infants of women fascinating Tegretol were 2,6 times more likely to have spina bifida, compared with women not alluring any anti-epileptic medication.
However, the risk associated with Tegretol was less than with another anti-epileptic drug- valproic acid (Depakene). In fact, Tegretol was less perilous than valproic acid when it came to other family defects such as hypospadias, where a boy's urinary crack develops in the out of place part of the penis or in the scrotum. "Carbamazepine is specifically coordinate to an increased risk of spina bifida," de Jong-van den Berg said. "But you have to commemorate in mind that the absolute danger is small".
Pregnant women with epilepsy who are compelling carbamazepine (Tegretol) to device seizures may be at a minor extent increased hazard of having an infant with spina bifida, a further study finds. Spina bifida is a get in which the bones of the spine do not close but the spinal line remains in place, usually with skin covering the defect skin care with peptides. Most children will stress lifelong treatment for problems arising from devastation to the spinal cord and spinal nerves.
And "For women with epilepsy, paroxysm control during pregnancy is very important," said pass researcher Lolkje de Jong-van den Berg, from the borderline of pharmacy at the University of Groningen in the Netherlands. "Our weigh can help in decisions regarding whether carbamazepine should be the drug of superior in pregnancy". However, the best option regarding treatment can be chosen only on an personal basis by the woman and her neurologist before pregnancy, weighing the benefits of epilepsy put down against the risk of birth defects, de Jong-van den Berg said.
The write-up is published in the Dec 3, 2010 online number of the BMJ. For the study, de Jong-van den Berg's duo reviewed existing fact-finding to determine the risk of birth defects among women fetching Tegretol. The researchers found that infants of women fascinating Tegretol were 2,6 times more likely to have spina bifida, compared with women not alluring any anti-epileptic medication.
However, the risk associated with Tegretol was less than with another anti-epileptic drug- valproic acid (Depakene). In fact, Tegretol was less perilous than valproic acid when it came to other family defects such as hypospadias, where a boy's urinary crack develops in the out of place part of the penis or in the scrotum. "Carbamazepine is specifically coordinate to an increased risk of spina bifida," de Jong-van den Berg said. "But you have to commemorate in mind that the absolute danger is small".
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