Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles

Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles.
A fresh technology that for the meantime zaps away forehead wrinkles by freezing the nerves shows assurance in early clinical trials, researchers say. The technique, if at last approved by the US Food and Drug Administration, could provide an alternative to Botox and Dysport. Both are injectable forms of Botulinum toxin typeface A, a neurotoxin that, when injected in lesser quantities, temporarily paralyzes facial muscles, thereby reducing wrinkles. "It's a toxin-free other to treating unwanted lines and wrinkles, similar to what is being done with Botox and Dysport," said deliberate over co-author Francis Palmer, director of facial plastic surgery at the University of Southern California School of Medicine in Los Angeles.

And "From the antique clinical trials, this procedure - which its maker calls cryoneuromodulation - appears to have the same clinical efficacy and cover comparable to the existing techniques". Palmer is also consulting medical supervisor of MyoScience Inc, the Redwood City (California) - based circle developing the cryotechnology. The results of the clinical trials were to be presented Friday at an American Society for Laser Medicine and Surgery (ASLMS) congress in Grapevine, Texas.

To do the procedure, physicians use slight needles - "cryoprobes" - to deliver cold to nerves continual through the forehead, specifically the temporal branch of the frontal nerve. The cold freezes the nerve, which interrupts the gall signal and relaxes the muscle that causes vertical and horizontal forehead lines. Although the temerity quickly returns to normal body temperature, the cold temporarily "injures" the nerve, allowing the beckon to remain interrupted for some period of time after the patient leaves the office.

The manner does not permanently damage the nerve. Researchers said they are still refining the technique and could not say how crave the effect lasts, but it seems to be comparable to Botox, which works for about three to four months. Physicians would call for training to identify the nerve that should be targeted.

Excessive Use Of Antibiotics In Animal Husbandry Creates A Deadly Intestinal Bacteria

Excessive Use Of Antibiotics In Animal Husbandry Creates A Deadly Intestinal Bacteria.
The make an effort of E coli bacteria that this month killed dozens of populate in Europe and sickened thousands more may be more brutal because of the way it has evolved, a new swot suggests. Scientists say this strain of E coli produces a particularly noxious toxin and also has a gluey ability to hold on to cells within the intestine. This, alongside the fact that it is also resistant to many antibiotics, has made the ostensible O104:H4 strain both deadlier and easier to transmit, German researchers report.

And "This ancestry of E coli is much nastier than its more common cousin E coli O157, which is spiteful enough - about three times more virulent," said Hugh Pennington, emeritus professor of bacteriology at the University of Aberdeen in Scotland and originator of an accompanying editorial published online June 23, 2011 in The Lancet Infectious Diseases. Another study, published the same prime in the New England Journal of Medicine, concludes that, as of June 18, 2011, more than 3200 common people have fallen trouble in Germany due to the outbreak, including 39 deaths.

In fact, the German descent - traced to sprouts raised at a German organic farm - "was honest for the deadliest E coli outbreak in history. It may well be so nasty because it combines the virulence factors of shiga toxin, produced by E coli O157, and the workings for sticking to intestinal cells second-hand by another strain of E coli, enteroaggregative E coli, which is known to be an important cause of diarrhea in poorer countries".

Shiga toxin can also worker spur what doctors call "hemolytic uremic syndrome," a potentially disastrous form of kidney failure. In the New England Journal of Medicine study, German researchers approximately that 25 percent of outbreak cases involved this complication. The bottom line, according to Pennington: "E coli hasn't gone away. It still springs surprises".

To upon out how this overburden of the intestinal bug proved so lethal, researchers led by Dr Helge Karch from the University of Munster feigned 80 samples of the bacteria from affected patients. They tested the samples for shiga toxin-producing E coli and also for perniciousness genes of other types of E coli.