The List Of Children Needing A Liver Transplantation Increases Every Year.
Transplanting one-sided livers from deceased teen and full-grown donors to infants is less perilous than in the past and helps save lives, according to a new study June 2013. The hazard of organ failure and death among infants who receive a partial liver relocate is now comparable to that of infants who receive whole livers, according to the study, which was published online in the June pay-off of the journal Liver Transplantation. Size-matched livers for infants are in short supply and the use of partial grafts from deceased donors now accounts for almost one-third of liver transplants in children, the researchers said.
And "Infants and uninitiated children have the highest waitlist mortality rates surrounded by all candidates for liver transplant," lessons senior author Dr Heung Bae Kim, director of the Pediatric Transplant Center at Boston Children's Hospital, said in a gazette news release. "Extended point on the liver transplant waitlist also places children at greater risk for long-term health issues and progress delays, which is why it is so important to look for methods that shorten the waitlist time to reduce mortality and take a turn for the better quality of life for pediatric patients".
Friday, 26 February 2016
Monday, 22 February 2016
Pathological Heart Rhythm Is Related To Alzheimer's Disease
Pathological Heart Rhythm Is Related To Alzheimer's Disease.
People with atrial fibrillation, a material of eccentric heart rhythm, are more likely than others to develop dementia, including Alzheimer's disease, a redone study finds. The presence of atrial fibrillation also predicted higher expiry rates in dementia patients, especially among younger patients in the rank studied, meaning under the age of 70.
So "This leaves us with the finding that atrial fibrillation, non-affiliated of everything else, is a risk factor for dementia," said Dr Gary Kennedy, chairman of geriatric psychiatry at Montefiore Medical Center in New York City. "This is adding one more block in the road toward understanding that cardiovascular disease is a major risk factor for dementia".
Now "Alzheimer's disease, in particular, is one where we don't truly understand the risk factors and what causes it, so studies counterpart this that try to investigate the causative effect will help us understand that and ultimately design therapies and approaches to hamper or minimize disease," added Dr Jared Bunch. Who are be conducive to author of a study appearing in the April edition of the HeartRhythm Journal and a cardiologist or electrophysiologist with Intermountain Medical Center in Murray, Utah.
This study, however, was not specifically set up to confirm a direct cause-and-effect relationship. The authors looked at 37025 patients without atrial fibrillation or dementia, grey 60 to 90, over a five-year period. Individuals who developed atrial fibrillation had a higher endanger of all types of dementia, even when other chance factors were taken into account. Alzheimer's disease is by far the most common coin of dementia.
People with atrial fibrillation, a material of eccentric heart rhythm, are more likely than others to develop dementia, including Alzheimer's disease, a redone study finds. The presence of atrial fibrillation also predicted higher expiry rates in dementia patients, especially among younger patients in the rank studied, meaning under the age of 70.
So "This leaves us with the finding that atrial fibrillation, non-affiliated of everything else, is a risk factor for dementia," said Dr Gary Kennedy, chairman of geriatric psychiatry at Montefiore Medical Center in New York City. "This is adding one more block in the road toward understanding that cardiovascular disease is a major risk factor for dementia".
Now "Alzheimer's disease, in particular, is one where we don't truly understand the risk factors and what causes it, so studies counterpart this that try to investigate the causative effect will help us understand that and ultimately design therapies and approaches to hamper or minimize disease," added Dr Jared Bunch. Who are be conducive to author of a study appearing in the April edition of the HeartRhythm Journal and a cardiologist or electrophysiologist with Intermountain Medical Center in Murray, Utah.
This study, however, was not specifically set up to confirm a direct cause-and-effect relationship. The authors looked at 37025 patients without atrial fibrillation or dementia, grey 60 to 90, over a five-year period. Individuals who developed atrial fibrillation had a higher endanger of all types of dementia, even when other chance factors were taken into account. Alzheimer's disease is by far the most common coin of dementia.
Friday, 19 February 2016
The Normalization Of Weight A Woman After Childbirth Reduces The Risk Of Developing Diabetes
The Normalization Of Weight A Woman After Childbirth Reduces The Risk Of Developing Diabetes.
Women who gained 18 or more pounds after their start newborn was born are more than three times more undoubtedly to develop gestational diabetes during their second pregnancy, according to rejuvenated research. On the bright side, the study, published in the May 23 online printing of Obstetrics & Gynecology, also found that women who were able to shed six or more pounds between babies reduced their risk of the condition by 50 percent. Gestational diabetes, a condition that occurs during pregnancy, can cause honest complications in the final weeks of pregnancy, birth and right after a baby is born.
Research shows that women who have had the get during one pregnancy have a greater chance of developing the condition again. Excess weight profit before or during pregnancy also boosts a woman's risk. But women who trim extra pounds after the nativity of a baby could significantly reduce their risk of developing gestational diabetes in a subsequent pregnancy.
Women who gained 18 or more pounds after their start newborn was born are more than three times more undoubtedly to develop gestational diabetes during their second pregnancy, according to rejuvenated research. On the bright side, the study, published in the May 23 online printing of Obstetrics & Gynecology, also found that women who were able to shed six or more pounds between babies reduced their risk of the condition by 50 percent. Gestational diabetes, a condition that occurs during pregnancy, can cause honest complications in the final weeks of pregnancy, birth and right after a baby is born.
Research shows that women who have had the get during one pregnancy have a greater chance of developing the condition again. Excess weight profit before or during pregnancy also boosts a woman's risk. But women who trim extra pounds after the nativity of a baby could significantly reduce their risk of developing gestational diabetes in a subsequent pregnancy.
Thursday, 18 February 2016
Healing Diabetes In Animals, We Help Heal People
Healing Diabetes In Animals, We Help Heal People.
Daniela Trnka had been living with order 1 diabetes for almost 20 years when she noticed telltale signs of the disability in her Siberian Husky, Cooper. He was thirsty, urinating often and at times, lethargic. So she took out her blood sugar assay kit, opened a vigorous lancet and took a slacken of his blood. Cooper's blood glucose levels were too high. A veterinarian confirmed it: Cooper had diabetes.
Now, the two are coping with the fit together. Trnka monitors Cooper's blood sugar levels and gives him insulin injections. Caring for her pet, Trnka says, has helped her strike better regard to her own health. "Every time I think to check his sugar, I'm checking mine. I fantasize I'm more on top of managing my diabetes since I started taking worry of him".
Trnka recently participated in a new Canadian study focused on pets with diabetes, which found that caring for a up to snuff pet may improve the pet owner's health as well. Lead con author Melanie Rock, an investigator at the Population Health Intervention Research Center, and a ally interviewed 16 pet owners as well as veterinarians, a mental health counselor and a pharmacist about what it takes to persuade care of dogs and cats with the disease. About 1 in 500 dogs and 1 in 250 cats in developed nations are treated for diabetes, according to credentials information in the study in the May 17 outgoing of Anthrozoos.
Some participants said they had learned so much about the condition they felt better equipped to acquire care of a person with diabetes should they need to. Others, like Trnka, became more diligent about exercising continually for their pets' sake. "On a cold, windy day, my dog gets me worst in the fresh air because I know the exercise is good for him. And that's wholesome for me too," she told the researchers.
So "What we observed was that people take the care of their pet very seriously, and in doing so, they fogginess the lines between their own health and their pets' health. Being responsible for a dog may get common people up and out of the house on a rainy day". In addition, many pet owners get a crash process in diabetes, a disease linked to obesity, heart disease, kidney problems and a host of other ills.
Daniela Trnka had been living with order 1 diabetes for almost 20 years when she noticed telltale signs of the disability in her Siberian Husky, Cooper. He was thirsty, urinating often and at times, lethargic. So she took out her blood sugar assay kit, opened a vigorous lancet and took a slacken of his blood. Cooper's blood glucose levels were too high. A veterinarian confirmed it: Cooper had diabetes.
Now, the two are coping with the fit together. Trnka monitors Cooper's blood sugar levels and gives him insulin injections. Caring for her pet, Trnka says, has helped her strike better regard to her own health. "Every time I think to check his sugar, I'm checking mine. I fantasize I'm more on top of managing my diabetes since I started taking worry of him".
Trnka recently participated in a new Canadian study focused on pets with diabetes, which found that caring for a up to snuff pet may improve the pet owner's health as well. Lead con author Melanie Rock, an investigator at the Population Health Intervention Research Center, and a ally interviewed 16 pet owners as well as veterinarians, a mental health counselor and a pharmacist about what it takes to persuade care of dogs and cats with the disease. About 1 in 500 dogs and 1 in 250 cats in developed nations are treated for diabetes, according to credentials information in the study in the May 17 outgoing of Anthrozoos.
Some participants said they had learned so much about the condition they felt better equipped to acquire care of a person with diabetes should they need to. Others, like Trnka, became more diligent about exercising continually for their pets' sake. "On a cold, windy day, my dog gets me worst in the fresh air because I know the exercise is good for him. And that's wholesome for me too," she told the researchers.
So "What we observed was that people take the care of their pet very seriously, and in doing so, they fogginess the lines between their own health and their pets' health. Being responsible for a dog may get common people up and out of the house on a rainy day". In addition, many pet owners get a crash process in diabetes, a disease linked to obesity, heart disease, kidney problems and a host of other ills.
Tuesday, 16 February 2016
Allergies Can Lead To Depression
Allergies Can Lead To Depression.
Allergy mellow may not mean just the absolute coughing, sneezing and itching, it could also significantly darken your mood. Researchers reported that finding at the American Psychiatric Association's annual convocation in New Orleans this week. "Depression is a very common disorder and allergies are even more common," said workroom author Dr Partam Manalai, in the department of psychiatry at the University of Maryland School of Medicine in Baltimore. "Allergies produce one more prone to worsening mood, cognition and blue blood of life".
A large peak in pollen particles floating in the air occurs in the spring, with a smaller summit in the fall. This coincides with a worldwide spike in suicides every spring and a disgrace peak in the fall. To explore this relationship, Manalai and his colleagues recruited 100 volunteers from Baltimore and Washington, DC, who had dominant depression. About half were allergic and half were not allergic to trees and/or ragweed pollen.
Volunteers were evaluated during both high-pollen ripen and low-pollen season, and also had levels of their IgE antibodies (a system of sensitivity to allergens) measured. This is believed to be the first place study to link actual IgE measurements with depression scores.
Allergy mellow may not mean just the absolute coughing, sneezing and itching, it could also significantly darken your mood. Researchers reported that finding at the American Psychiatric Association's annual convocation in New Orleans this week. "Depression is a very common disorder and allergies are even more common," said workroom author Dr Partam Manalai, in the department of psychiatry at the University of Maryland School of Medicine in Baltimore. "Allergies produce one more prone to worsening mood, cognition and blue blood of life".
A large peak in pollen particles floating in the air occurs in the spring, with a smaller summit in the fall. This coincides with a worldwide spike in suicides every spring and a disgrace peak in the fall. To explore this relationship, Manalai and his colleagues recruited 100 volunteers from Baltimore and Washington, DC, who had dominant depression. About half were allergic and half were not allergic to trees and/or ragweed pollen.
Volunteers were evaluated during both high-pollen ripen and low-pollen season, and also had levels of their IgE antibodies (a system of sensitivity to allergens) measured. This is believed to be the first place study to link actual IgE measurements with depression scores.
Thursday, 4 February 2016
Appearance Of Cigarette Packs Will Not Change In The US
Appearance Of Cigarette Packs Will Not Change In The US.
The US direction won't chase a legal battle to mandate large, revolting images on cigarette labeling in an effort to dissuade potential smokers and get current smokers to quit. According to a note from Attorney General Eric Holder obtained by the Associated Press, the US Food and Drug Administration now plans to revamp its proposed label changes with less unnerving approaches. The decision comes ahead of a Monday deadline set for the agency to petition the US Supreme Court on the issue.
In August, 2013, an appeals court upheld a one-time ruling that the labeling prerequisite infringed on First Amendment free speech protections. "In shed of these circumstances, the Solicitor General has determined not to seek Supreme Court review of the First Amendment issues at the mount time," Holder wrote in the Friday letter to House of Representatives' Speaker John Boehner.
The proposed mark requirement from the FDA - which had been set to begin last September - would have emblazoned cigarette packaging with images of the crowd dying from smoking-related disease, mouth and gum price linked to smoking and other graphic portrayals of the harms of smoking. Some of the nation's largest tobacco companies filed lawsuits to invalidate the precondition for the new labels.
The companies contended that the proposed warnings went beyond precise information into anti-smoking advocacy, the AP reported. In February 2012, Judge Richard Leon, of the US District Court in the District of Columbia, ruled that the FDA mandate violated the US Constitution's unchain oration amendment. And in August, a US appeals court upheld that earlier court ruling.
The US direction won't chase a legal battle to mandate large, revolting images on cigarette labeling in an effort to dissuade potential smokers and get current smokers to quit. According to a note from Attorney General Eric Holder obtained by the Associated Press, the US Food and Drug Administration now plans to revamp its proposed label changes with less unnerving approaches. The decision comes ahead of a Monday deadline set for the agency to petition the US Supreme Court on the issue.
In August, 2013, an appeals court upheld a one-time ruling that the labeling prerequisite infringed on First Amendment free speech protections. "In shed of these circumstances, the Solicitor General has determined not to seek Supreme Court review of the First Amendment issues at the mount time," Holder wrote in the Friday letter to House of Representatives' Speaker John Boehner.
The proposed mark requirement from the FDA - which had been set to begin last September - would have emblazoned cigarette packaging with images of the crowd dying from smoking-related disease, mouth and gum price linked to smoking and other graphic portrayals of the harms of smoking. Some of the nation's largest tobacco companies filed lawsuits to invalidate the precondition for the new labels.
The companies contended that the proposed warnings went beyond precise information into anti-smoking advocacy, the AP reported. In February 2012, Judge Richard Leon, of the US District Court in the District of Columbia, ruled that the FDA mandate violated the US Constitution's unchain oration amendment. And in August, a US appeals court upheld that earlier court ruling.
Tuesday, 2 February 2016
The New Increase In Cigarette Prices Would Reduce The Number Of Smokers
The New Increase In Cigarette Prices Would Reduce The Number Of Smokers.
Boosting cigarette taxes can cause smoking rates to plummet to each hoi polloi struggling with alcohol, deaden and/or mental disorders, new research suggests. The ponder authors found that raising the price of cigarettes by just 10 percent translates into more than an 18 percent fire in smoking among such individuals. "Whatever we can do to reduce smoking is critical to the salubriousness of the US," Dr Michael Ong, a researcher at the Jonsson Cancer Center at the University of California Los Angeles, said in a account release.
So "Cigarette taxes are used as a key principle instrument to get people to quit smoking, so understanding whether people will really quit is important. Individuals with alcohol, cure-all or mental disorders comprise 40 percent of remaining smokers, and there is short literature on how to help these people quit smoking".
Boosting cigarette taxes can cause smoking rates to plummet to each hoi polloi struggling with alcohol, deaden and/or mental disorders, new research suggests. The ponder authors found that raising the price of cigarettes by just 10 percent translates into more than an 18 percent fire in smoking among such individuals. "Whatever we can do to reduce smoking is critical to the salubriousness of the US," Dr Michael Ong, a researcher at the Jonsson Cancer Center at the University of California Los Angeles, said in a account release.
So "Cigarette taxes are used as a key principle instrument to get people to quit smoking, so understanding whether people will really quit is important. Individuals with alcohol, cure-all or mental disorders comprise 40 percent of remaining smokers, and there is short literature on how to help these people quit smoking".
Monday, 1 February 2016
Promising Transplants Of Blood Vessels For Dialysis Patients
Promising Transplants Of Blood Vessels For Dialysis Patients.
In at research, blood vessels originating from a donor's coating cells and grown in a laboratory have been successfully implanted in three dialysis patients. These engineered grafts have functioned well for about 8 months, think researchers reporting Monday at a momentous online conference sponsored by the American Heart Association. The three patients - all of whom lived in Poland and were on dialysis for end-stage kidney disability - received the unfledged vessels to allow better access for dialysis.
But the foresee is that these types of bioengineered, "off-the-shelf" tissues can someday be used as replacement arteries throughout the body, including sentiment bypass. "The grafts available now perform quite poorly," said margin researcher Todd N McAllister, co-founder and chief executive officer of Cytograft Tissue Engineering Inc, the Novato, California-based maker of the grafts and the funder of the study. Currently, these types of vessels are typically made of plastic papers or they are grafts of the patient's own veins.
In either cause the rate of failure and the need for redoing the procedures remains high. In the new study, contributor skin cells were used to grow the blood vessels. The vessels were made from sheets of cultured hide cells, rolled around a temporary support structure in the lab.
Upon implantation the vessels typically deliberate about a foot long and a fifth of an inch in diameter. After implantation, the vessels were occupied as "shunts" between arteries and veins in the arm to gave the patient access to life-saving dialysis. "To go out all the grafts are patent functioning well. Perhaps most interestingly, we have seen no clinical manifestations of an insusceptible response".
In at research, blood vessels originating from a donor's coating cells and grown in a laboratory have been successfully implanted in three dialysis patients. These engineered grafts have functioned well for about 8 months, think researchers reporting Monday at a momentous online conference sponsored by the American Heart Association. The three patients - all of whom lived in Poland and were on dialysis for end-stage kidney disability - received the unfledged vessels to allow better access for dialysis.
But the foresee is that these types of bioengineered, "off-the-shelf" tissues can someday be used as replacement arteries throughout the body, including sentiment bypass. "The grafts available now perform quite poorly," said margin researcher Todd N McAllister, co-founder and chief executive officer of Cytograft Tissue Engineering Inc, the Novato, California-based maker of the grafts and the funder of the study. Currently, these types of vessels are typically made of plastic papers or they are grafts of the patient's own veins.
In either cause the rate of failure and the need for redoing the procedures remains high. In the new study, contributor skin cells were used to grow the blood vessels. The vessels were made from sheets of cultured hide cells, rolled around a temporary support structure in the lab.
Upon implantation the vessels typically deliberate about a foot long and a fifth of an inch in diameter. After implantation, the vessels were occupied as "shunts" between arteries and veins in the arm to gave the patient access to life-saving dialysis. "To go out all the grafts are patent functioning well. Perhaps most interestingly, we have seen no clinical manifestations of an insusceptible response".
Sunday, 31 January 2016
Preliminary Testing Of New Drug Against Hepatitis C Shows Good Promise
Preliminary Testing Of New Drug Against Hepatitis C Shows Good Promise.
Researchers are reporting that a treatment is showing likelihood in early testing as a admissible new treatment for hepatitis C, a stubborn and potentially deadly liver ailment. It's too old to tell if the drug actually works, and it will be years before it's ready to seek federal authorization to be prescribed to patients. Still, the drug - or others like it in development - could reckon to the power of new drugs in the pipeline that are poised to cure many more people with hepatitis C, said Dr Eugene R Schiff, numero uno of the University of Miami's Center for Liver Diseases.
The greater likelihood of a cure and fewer side effects, in turn, will lead more settle who think they have hepatitis C to "come out of the woodwork," said Schiff, who's familiar with the on findings. "They'll want to know if they're positive". An estimated 4 million mortals in the United States have hepatitis C, but only about 1 million are thought to have been diagnosed.
The disease, transmitted through infected blood, can standard to liver cancer, scarring of the liver, known as cirrhosis, and death. Existing treatments can preserve about half of the cases. As Schiff explained, people's genetic makeup has a lot to do with whether they rejoin to the treatment. Those with Asian heritage do better, whereas those with an African family do worse.
And there's another potential problem with existing treatments. The side effects, unusually of the treatment component known as interferon, can be "pretty hard to deal with," said Nicholas A Meanwell, a co-author of the cram and a researcher with the Bristol-Myers Squibb pharmaceutical company.
Researchers are reporting that a treatment is showing likelihood in early testing as a admissible new treatment for hepatitis C, a stubborn and potentially deadly liver ailment. It's too old to tell if the drug actually works, and it will be years before it's ready to seek federal authorization to be prescribed to patients. Still, the drug - or others like it in development - could reckon to the power of new drugs in the pipeline that are poised to cure many more people with hepatitis C, said Dr Eugene R Schiff, numero uno of the University of Miami's Center for Liver Diseases.
The greater likelihood of a cure and fewer side effects, in turn, will lead more settle who think they have hepatitis C to "come out of the woodwork," said Schiff, who's familiar with the on findings. "They'll want to know if they're positive". An estimated 4 million mortals in the United States have hepatitis C, but only about 1 million are thought to have been diagnosed.
The disease, transmitted through infected blood, can standard to liver cancer, scarring of the liver, known as cirrhosis, and death. Existing treatments can preserve about half of the cases. As Schiff explained, people's genetic makeup has a lot to do with whether they rejoin to the treatment. Those with Asian heritage do better, whereas those with an African family do worse.
And there's another potential problem with existing treatments. The side effects, unusually of the treatment component known as interferon, can be "pretty hard to deal with," said Nicholas A Meanwell, a co-author of the cram and a researcher with the Bristol-Myers Squibb pharmaceutical company.
Saturday, 30 January 2016
Excess Weight Is Not The Verdict
Excess Weight Is Not The Verdict.
For the basic time, researchers have shown that implanting electrodes in the brain's "feeding center" can be safely done - in a tell to unfold a new treatment option for severely obese people who fail to shed pounds even after weight-loss surgery. In a initial study with three patients, researchers in June 2013 found that they could safely use the therapy, known as designing brain stimulation (DBS). Over almost three years, none of the patients had any straightforward side effects, and two even lost some weight - but it was temporary. "The in the first place thing we needed to do was to see if this is safe," said lead researcher Dr Donald Whiting, villainy chairman of neurosurgery at Allegheny General Hospital in Pittsburgh.
And "We're at the point now where it looks get off on it is". The study, reported in the Journal of Neurosurgery and at a meeting this week of the International Neuromodulation Society in Berlin, Germany, was not meant to exam effectiveness. So the big remaining difficulty is, can deep brain stimulation actually promote lasting weight loss?
"Nobody should get the image that this has been shown to be effective. This is not something you can go ask your doctor about". Right now, deep capacity stimulation is sometimes used for tough-to-treat cases of Parkinson's disease, a movement disorder that causes tremors, laborious muscles, and balance and coordination problems. A surgeon implants electrodes into unambiguous movement-related areas of the brain, then attaches those electrodes to a neurostimulator placed under the skin near the collarbone.
The neurostimulator continually sends elfin electrical pulses to the brain, which in turn interferes with the unusual activity that causes tremors and other symptoms. What does that have to do with obesity? In theory deep perception stimulation might be able to "override" brain signaling involved in eating, metabolism or feelings of fullness.
Research in animals has shown that electrical stimulation of a picky area of the brain - the lateral hypothalamic area - can excite weight loss even if calorie intake stays the same. The new writing-room marks the first time that deep brain stimulation has been tried in that brain region. And it's an grave first step to show that not only could these three severely obese people get through the surgery, but they also seemed to have no vital effects from the brain stimulation, said Dr Casey Halpern, a neurosurgeon at the University of Pennsylvania who was not labyrinthine in the research.
For the basic time, researchers have shown that implanting electrodes in the brain's "feeding center" can be safely done - in a tell to unfold a new treatment option for severely obese people who fail to shed pounds even after weight-loss surgery. In a initial study with three patients, researchers in June 2013 found that they could safely use the therapy, known as designing brain stimulation (DBS). Over almost three years, none of the patients had any straightforward side effects, and two even lost some weight - but it was temporary. "The in the first place thing we needed to do was to see if this is safe," said lead researcher Dr Donald Whiting, villainy chairman of neurosurgery at Allegheny General Hospital in Pittsburgh.
And "We're at the point now where it looks get off on it is". The study, reported in the Journal of Neurosurgery and at a meeting this week of the International Neuromodulation Society in Berlin, Germany, was not meant to exam effectiveness. So the big remaining difficulty is, can deep brain stimulation actually promote lasting weight loss?
"Nobody should get the image that this has been shown to be effective. This is not something you can go ask your doctor about". Right now, deep capacity stimulation is sometimes used for tough-to-treat cases of Parkinson's disease, a movement disorder that causes tremors, laborious muscles, and balance and coordination problems. A surgeon implants electrodes into unambiguous movement-related areas of the brain, then attaches those electrodes to a neurostimulator placed under the skin near the collarbone.
The neurostimulator continually sends elfin electrical pulses to the brain, which in turn interferes with the unusual activity that causes tremors and other symptoms. What does that have to do with obesity? In theory deep perception stimulation might be able to "override" brain signaling involved in eating, metabolism or feelings of fullness.
Research in animals has shown that electrical stimulation of a picky area of the brain - the lateral hypothalamic area - can excite weight loss even if calorie intake stays the same. The new writing-room marks the first time that deep brain stimulation has been tried in that brain region. And it's an grave first step to show that not only could these three severely obese people get through the surgery, but they also seemed to have no vital effects from the brain stimulation, said Dr Casey Halpern, a neurosurgeon at the University of Pennsylvania who was not labyrinthine in the research.
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