US Doctors Concerned About The Emerging Diseases Measles.
Although measles has been nearly eliminated in the United States, outbreaks still chance here. And they're mostly triggered by people infected abroad, in countries where widespread vaccination doesn't exist, federal salubrity officials said Thursday. And while it's been 50 years since the introduction of the measles vaccine, the approvingly infectious and potentially fatal respiratory disease still poses a international threat. Every day some 430 children around the world die of measles.
In 2011, there were an estimated 158000 deaths, according to the US Centers for Disease Control and Prevention. "Measles is quite the unique most infectious of all infectious diseases," CDC director Dr Thomas Frieden said during an afternoon scuttlebutt conference. Dramatic progress has been made in eliminating measles, but much more needs to be done. "We are not anywhere near the wrap up line.
In a new study in the Dec 5, 2013 issue of the roll JAMA Pediatrics, CDC researcher Dr Mark Papania and colleagues found that the elimination of measles in the United States that was announced in 2000 had been continued through 2011. Elimination means no continuous disease transmitting for more than 12 months. "But elimination is not eradication. As long as there is measles anywhere in the men there is a threat of measles anywhere else in the world".
And "We have seen an increasing number of cases in recent years coming from a ample variety of countries. Over this year, we have had 52 separate, known importations, with about half of them coming from Europe". Before the US vaccination program started in 1963, an estimated 450 to 500 settle died in the United States from measles each year; 48000 were hospitalized; 7000 had seizures; and some 1000 rank and file suffered unending brain damage or deafness. Since widespread vaccination, there has been an unexceptional of 60 cases a year, Dr Alan Hinman, head for programs at the Center for Vaccine Equity of the Task Force for Global Health, said at the story conference.
Tuesday, 3 December 2019
Scientists Have Submitted A New Drug To Treat HIV
Scientists Have Submitted A New Drug To Treat HIV.
Scientists are reporting ancient but optimistic results from a new drug that blocks HIV as it attempts to invade considerate cells. The approach differs from most current antiretroviral therapy, which tries to restrain the virus only after it has gained entry to cells. The medication, called VIR-576 for now, is still in the primeval phases of development.
But researchers say that if it is successful, it might also circumvent the drug resistance that can subvert standard therapy, according to a report published Dec 22 2010 in Science Translational Medicine. The experimental approach is an attractive one for a number of reasons, said Dr Michael Horberg, head of HIV/AIDS for Kaiser Permanente in Santa Clara, California. "Theoretically it should have fewer lesser effects and indeed had minimal adverse events in this study and there's probably less of a chance of changing in developing resistance to medication," said Horberg, who was not involved in the study.
Viruses replicate inside cells and scientists have extensive known that this is when they tend to mutate - potentially developing new ways to stand up drugs. "It's generally accepted that it's harder for a virus to mutate surface cell walls".
The new drug focuses on HIV at this pre-invasion stage. "VIR-576 targets a neighbourhood of the virus that is different from that targeted by all other HIV-1 inhibitors," explained study co-author Frank Kirchhoff, a professor at the Institute of Molecular Virology, University Hospital of Ulm in Ulm, Germany, who, along with several other researchers, holds a evident on the unfamiliar medication. The target is the gp41 fusion peptide of HIV, the "sticky" end of the virus's outer membrane, which "shoots get off on a 'harpoon'" into the body's cells, the authors said.
Scientists are reporting ancient but optimistic results from a new drug that blocks HIV as it attempts to invade considerate cells. The approach differs from most current antiretroviral therapy, which tries to restrain the virus only after it has gained entry to cells. The medication, called VIR-576 for now, is still in the primeval phases of development.
But researchers say that if it is successful, it might also circumvent the drug resistance that can subvert standard therapy, according to a report published Dec 22 2010 in Science Translational Medicine. The experimental approach is an attractive one for a number of reasons, said Dr Michael Horberg, head of HIV/AIDS for Kaiser Permanente in Santa Clara, California. "Theoretically it should have fewer lesser effects and indeed had minimal adverse events in this study and there's probably less of a chance of changing in developing resistance to medication," said Horberg, who was not involved in the study.
Viruses replicate inside cells and scientists have extensive known that this is when they tend to mutate - potentially developing new ways to stand up drugs. "It's generally accepted that it's harder for a virus to mutate surface cell walls".
The new drug focuses on HIV at this pre-invasion stage. "VIR-576 targets a neighbourhood of the virus that is different from that targeted by all other HIV-1 inhibitors," explained study co-author Frank Kirchhoff, a professor at the Institute of Molecular Virology, University Hospital of Ulm in Ulm, Germany, who, along with several other researchers, holds a evident on the unfamiliar medication. The target is the gp41 fusion peptide of HIV, the "sticky" end of the virus's outer membrane, which "shoots get off on a 'harpoon'" into the body's cells, the authors said.
The Prevalence Of Adolescent Violence In Schools
The Prevalence Of Adolescent Violence In Schools.
Almost one-fifth of high-school students receive they physically hurt someone they were dating, and those same students were likely to have misused other students and their siblings, a new study finds. The study provides new details about the links between various types of violence, said reflect on lead author Emily F Rothman, an partner professor at the Boston University School of Public Health. "There's a huge overall connecting between perpetration of dating violence and the perpetration of other forms of youth violence. The majority of students who were being fit to be tied with their dating partners were generally violent. They weren't selecting their dating partners specifically for violence".
For the study, published in the December egress of the journal Pediatrics, the researchers surveyed 1,398 urban tall school students at 22 schools in Boston in 2008 and asked if they had physically cut to the quick a girlfriend or boyfriend, sibling or peer within the previous month. The authors out physical abuse as "pushing, shoving, slapping, hitting, punching, kicking, or choking". Playful belligerence was excluded.
More than forty-one percent said they'd physically hurt another kid on at least one gala the previous month; 31,2 percent reported that they'd physically ill-treated their siblings, and nearly 19 percent said they'd abused their boyfriend, girlfriend, someone they were dating or someone they were modestly having sex with. Among those admitted to dating violence, 9,9 percent reported kicking, hitting, or choking a partner; 17,6 percent said they had shoved or slapped a partner, and 42,8 percent had cursed at or called him or her "fat," "ugly," "stupid" or a nearly the same insult.
Almost one-fifth of high-school students receive they physically hurt someone they were dating, and those same students were likely to have misused other students and their siblings, a new study finds. The study provides new details about the links between various types of violence, said reflect on lead author Emily F Rothman, an partner professor at the Boston University School of Public Health. "There's a huge overall connecting between perpetration of dating violence and the perpetration of other forms of youth violence. The majority of students who were being fit to be tied with their dating partners were generally violent. They weren't selecting their dating partners specifically for violence".
For the study, published in the December egress of the journal Pediatrics, the researchers surveyed 1,398 urban tall school students at 22 schools in Boston in 2008 and asked if they had physically cut to the quick a girlfriend or boyfriend, sibling or peer within the previous month. The authors out physical abuse as "pushing, shoving, slapping, hitting, punching, kicking, or choking". Playful belligerence was excluded.
More than forty-one percent said they'd physically hurt another kid on at least one gala the previous month; 31,2 percent reported that they'd physically ill-treated their siblings, and nearly 19 percent said they'd abused their boyfriend, girlfriend, someone they were dating or someone they were modestly having sex with. Among those admitted to dating violence, 9,9 percent reported kicking, hitting, or choking a partner; 17,6 percent said they had shoved or slapped a partner, and 42,8 percent had cursed at or called him or her "fat," "ugly," "stupid" or a nearly the same insult.
Operating Anesthetics Also Enhance The Greenhouse Effect
Operating Anesthetics Also Enhance The Greenhouse Effect.
Inhaled anesthetics in use to put patients to catch forty winks during surgery contribute to global climate change, according to a new study. Researchers constant that the use of these anesthetics by a busy hospital can contribute as much to climate change as the emissions from 100 to 1200 cars a year, depending on the epitome of anesthetic used, said University of California anesthesiologist Dr Susan M Ryan and kid study author Claus J Nielsen, a computer scientist at the University of Oslo in Norway.
The three outstanding inhaled anesthetics employed for surgery - sevoflurane, isoflurane, and desflurane - are recognized greenhouse gases, but their contribution to milieu change has received little attention because they're considered medically necessity and are used in relatively small amounts. These anesthetics undergo very little metabolic modulation in the body, the researchers noted.
Inhaled anesthetics in use to put patients to catch forty winks during surgery contribute to global climate change, according to a new study. Researchers constant that the use of these anesthetics by a busy hospital can contribute as much to climate change as the emissions from 100 to 1200 cars a year, depending on the epitome of anesthetic used, said University of California anesthesiologist Dr Susan M Ryan and kid study author Claus J Nielsen, a computer scientist at the University of Oslo in Norway.
The three outstanding inhaled anesthetics employed for surgery - sevoflurane, isoflurane, and desflurane - are recognized greenhouse gases, but their contribution to milieu change has received little attention because they're considered medically necessity and are used in relatively small amounts. These anesthetics undergo very little metabolic modulation in the body, the researchers noted.
This Is The First Trial Of Gene Therapy For Patients With Heart Failure
This Is The First Trial Of Gene Therapy For Patients With Heart Failure.
By substituting a thriving gene for a flawed one, scientists were able to restrictedly restore the heart's ability to pump in 39 heart failure patients, researchers report. "This is the anything else time gene therapy has been tested and shown to improve outcomes for patients with advanced pith failure," study lead author Dr Donna Mancini, professor of c physic and the Sudhir Choudhrie professor of cardiology at Columbia University College of Physicians and Surgeons in New York City, said in a university scuttlebutt release. "The psychotherapy works by replenishing levels of an enzyme necessary for the heart to pump more efficiently by introducing the gene for SERCA2a, which is depressed in these patients.
If these results are confirmed in time to come trials, this approach could be an alternative to kindliness transplant for patients without any other options". Mancini presented the results Monday at the annual meeting of the American Heart Association (AHA) in Chicago. The gene for SERCA2a raises levels of the enzyme back to where the tenderness can push more efficiently.
The enzyme regulates calcium cycling, which, in turn, is complicated in how well the heart contracts, the researchers said. "Heart failure is a defect in contractility related to calcium cycling," explained Dr Robert Eckel, defunct president of the AHA and professor of medication at the University of Colorado Denver.
By substituting a thriving gene for a flawed one, scientists were able to restrictedly restore the heart's ability to pump in 39 heart failure patients, researchers report. "This is the anything else time gene therapy has been tested and shown to improve outcomes for patients with advanced pith failure," study lead author Dr Donna Mancini, professor of c physic and the Sudhir Choudhrie professor of cardiology at Columbia University College of Physicians and Surgeons in New York City, said in a university scuttlebutt release. "The psychotherapy works by replenishing levels of an enzyme necessary for the heart to pump more efficiently by introducing the gene for SERCA2a, which is depressed in these patients.
If these results are confirmed in time to come trials, this approach could be an alternative to kindliness transplant for patients without any other options". Mancini presented the results Monday at the annual meeting of the American Heart Association (AHA) in Chicago. The gene for SERCA2a raises levels of the enzyme back to where the tenderness can push more efficiently.
The enzyme regulates calcium cycling, which, in turn, is complicated in how well the heart contracts, the researchers said. "Heart failure is a defect in contractility related to calcium cycling," explained Dr Robert Eckel, defunct president of the AHA and professor of medication at the University of Colorado Denver.
Experimental Diet Pill Contrave Brought A Small Weight Loss
Experimental Diet Pill Contrave Brought A Small Weight Loss.
Contrave, an experiential moment loss drug that combines an antidepressant with an anti-addiction medication, appears to assistant users shed pounds when taken along with a healthy diet and exercise, researchers report. People who took the numb for more than a year lost an average of 5 percent or more of body weight, depending on the dosage used, the team said. However, the regimen did come with side effects, and about half of weigh participants dropped out before completing a year of treatment.
Contrave is combination of two well-known drugs, naltrexone (Revia, cast-off to fight addictions) and the antidepressant bupropion (known by a number of names, including Wellbutrin). The drug, which is up for US Food and Drug Administration re-examination this December, appears to increase weight loss by changing the workings of the body's central nervous system, the researchers report.
The researchers, who write-up their findings online July 29, 2010 in The Lancet, enrolled men (15 percent) and women (85 percent) from around the country, ranging in length of existence from 18 to 65. They were all either pot-bellied or overweight with high blood fat levels or spacy blood pressure. The participants were told to eat less and exercise, and they were randomly assigned to gobble up a twice-daily placebo or a combination of the two drugs with naltrexone at one of two levels.
Contrave, an experiential moment loss drug that combines an antidepressant with an anti-addiction medication, appears to assistant users shed pounds when taken along with a healthy diet and exercise, researchers report. People who took the numb for more than a year lost an average of 5 percent or more of body weight, depending on the dosage used, the team said. However, the regimen did come with side effects, and about half of weigh participants dropped out before completing a year of treatment.
Contrave is combination of two well-known drugs, naltrexone (Revia, cast-off to fight addictions) and the antidepressant bupropion (known by a number of names, including Wellbutrin). The drug, which is up for US Food and Drug Administration re-examination this December, appears to increase weight loss by changing the workings of the body's central nervous system, the researchers report.
The researchers, who write-up their findings online July 29, 2010 in The Lancet, enrolled men (15 percent) and women (85 percent) from around the country, ranging in length of existence from 18 to 65. They were all either pot-bellied or overweight with high blood fat levels or spacy blood pressure. The participants were told to eat less and exercise, and they were randomly assigned to gobble up a twice-daily placebo or a combination of the two drugs with naltrexone at one of two levels.
Obese People Suffer From Hearing Loss
Obese People Suffer From Hearing Loss.
Listen up: Being obese, especially if you at those notably pounds around your waist, might be linked to hearing loss, a new mull over suggests in Dec 2013. Researchers tracked more than 68000 women participating in the Harvard Nurses' Health Study. Every two years from 1989 to 2009, the women answered precise questions about their strength and daily habits. In 2009, they were asked if they'd experienced hearing loss, and, if so, at what age.
One in six women reported hearing wastage during the on period, the researchers said. Those with a higher body-mass index (BMI) or larger waist circumference faced a higher hazard for hearing problems compared to normal-weight women. BMI is a determination of body fat based on a ratio of height and weight. Women who were obese, with BMIs between 30 and 39, were 17 percent to 22 percent more like as not to report hearing loss than women whose BMIs were less than 25.
Women who cut into the category of extreme obesity (BMIs over 40) had the highest jeopardy for hearing problems - about 25 percent higher than normal-weight women. Waist largeness also was tied to hearing loss. Women with waists larger than 34 inches were about 27 percent more apposite to report hearing loss than women with waists under 28 inches. Waist bigness remained a risk factor for hearing loss even after researchers factored in the effects of having a higher BMI, suggesting that carrying a lot of belly rich might impact hearing.
Those differences remained even after researchers controlled for other factors known to strike hearing, such as cigarette smoking, the use of certain medications and the eminence of a person's diet. One thing that seemed to change the relationship was exercise. When researchers factored carnal activity into the equation, the risk for hearing loss dropped. Women who walked for four or more hours each week gnome their risk for hearing loss drop by about 15 percent compared to women who walked less than an hour a week.
Listen up: Being obese, especially if you at those notably pounds around your waist, might be linked to hearing loss, a new mull over suggests in Dec 2013. Researchers tracked more than 68000 women participating in the Harvard Nurses' Health Study. Every two years from 1989 to 2009, the women answered precise questions about their strength and daily habits. In 2009, they were asked if they'd experienced hearing loss, and, if so, at what age.
One in six women reported hearing wastage during the on period, the researchers said. Those with a higher body-mass index (BMI) or larger waist circumference faced a higher hazard for hearing problems compared to normal-weight women. BMI is a determination of body fat based on a ratio of height and weight. Women who were obese, with BMIs between 30 and 39, were 17 percent to 22 percent more like as not to report hearing loss than women whose BMIs were less than 25.
Women who cut into the category of extreme obesity (BMIs over 40) had the highest jeopardy for hearing problems - about 25 percent higher than normal-weight women. Waist largeness also was tied to hearing loss. Women with waists larger than 34 inches were about 27 percent more apposite to report hearing loss than women with waists under 28 inches. Waist bigness remained a risk factor for hearing loss even after researchers factored in the effects of having a higher BMI, suggesting that carrying a lot of belly rich might impact hearing.
Those differences remained even after researchers controlled for other factors known to strike hearing, such as cigarette smoking, the use of certain medications and the eminence of a person's diet. One thing that seemed to change the relationship was exercise. When researchers factored carnal activity into the equation, the risk for hearing loss dropped. Women who walked for four or more hours each week gnome their risk for hearing loss drop by about 15 percent compared to women who walked less than an hour a week.
The Gene Responsible For Alzheimer's Disease
The Gene Responsible For Alzheimer's Disease.
Data that details every gene in the DNA of 410 ladies and gentlemen with Alzheimer's cancer can now be studied by researchers, the US National Institutes of Health announced this week. This ahead batch of genetic data is now available from the Alzheimer's Disease Sequencing Project, launched in February 2012 as component of an intensified national struggle to find ways to prevent and treat Alzheimer's disease. Genome sequencing outlines the apply for of all 3 billion chemical letters in an individual's DNA, which is the entire set of genetic data every soul carries in every cell.
And "Providing raw DNA sequence data to a wide range of researchers is a powerful, crowd-sourced nature to find genomic changes that put us at increased risk for this devastating disease," NIH Director Dr Francis Collins said in an introduce news release. "The genome poke out is designed to identify genetic risks for late onset of Alzheimer's disease, but it could also detect versions of genes that protect us".
Data that details every gene in the DNA of 410 ladies and gentlemen with Alzheimer's cancer can now be studied by researchers, the US National Institutes of Health announced this week. This ahead batch of genetic data is now available from the Alzheimer's Disease Sequencing Project, launched in February 2012 as component of an intensified national struggle to find ways to prevent and treat Alzheimer's disease. Genome sequencing outlines the apply for of all 3 billion chemical letters in an individual's DNA, which is the entire set of genetic data every soul carries in every cell.
And "Providing raw DNA sequence data to a wide range of researchers is a powerful, crowd-sourced nature to find genomic changes that put us at increased risk for this devastating disease," NIH Director Dr Francis Collins said in an introduce news release. "The genome poke out is designed to identify genetic risks for late onset of Alzheimer's disease, but it could also detect versions of genes that protect us".
Women In The US Have Less To Do Sports
Women In The US Have Less To Do Sports.
American mothers see more TV and get less mortal activity today than mothers did four decades ago, a green study finds. "With each passing generation, mothers have become increasingly physically inactive, desk-bound and obese, thereby potentially predisposing children to an increased risk of inactivity, adiposity body stoutness and chronic non-communicable diseases," said study leader Edward Archer, an perturb scientist and epidemiologist at the University of South Carolina. "Given that physical activity is an undiluted prerequisite for health and wellness, it is not surprising that inactivity is now a leading cause of death and disease in developed nations," Archer eminent in a university news release.
The analysis of 45 years of national material focused on two groups of mothers: those with children 5 years or younger, and those with children grey 6 to 18. The researchers assessed physical activity related to cooking, cleaning and exercising. From 1965 to 2010, the undistinguished amount of physical activity among mothers with younger children knock from 44 hours to less than 30 hours a week, resulting in a reduce in energy expenditure of 1573 calories per week.
American mothers see more TV and get less mortal activity today than mothers did four decades ago, a green study finds. "With each passing generation, mothers have become increasingly physically inactive, desk-bound and obese, thereby potentially predisposing children to an increased risk of inactivity, adiposity body stoutness and chronic non-communicable diseases," said study leader Edward Archer, an perturb scientist and epidemiologist at the University of South Carolina. "Given that physical activity is an undiluted prerequisite for health and wellness, it is not surprising that inactivity is now a leading cause of death and disease in developed nations," Archer eminent in a university news release.
The analysis of 45 years of national material focused on two groups of mothers: those with children 5 years or younger, and those with children grey 6 to 18. The researchers assessed physical activity related to cooking, cleaning and exercising. From 1965 to 2010, the undistinguished amount of physical activity among mothers with younger children knock from 44 hours to less than 30 hours a week, resulting in a reduce in energy expenditure of 1573 calories per week.
New Biochemical Technology For The Treatment Of Diabetes
New Biochemical Technology For The Treatment Of Diabetes.
A original bioengineered, microscopic organ dubbed the BioHub might one day offer people with variety 1 diabetes freedom from their disease. In its final stages, the BioHub would mimic a pancreas and work as a home for transplanted islet cells, providing them with oxygen until they could establish their own blood supply. Islet cells restrain beta cells, which are the cells that produce the hormone insulin. Insulin helps the body metabolize the carbohydrates found in foods so they can be in use as fuel for the body's cells. The BioHub also would give suppression of the immune system that would be confined to the area around the islet cells, or it's viable each islet cell might be encapsulated to protect it against the autoimmune attack that causes type 1 diabetes.
The beginning step, however, is to load islet cells into the BioHub and transplant it into an region of the abdomen known as the omentum. These trials are expected to begin within the next year or year and a half, said Dr Luca Inverardi, legate director of translational research at the Diabetes Research Institute at the University of Miami, where the BioHub is being developed.
Dr Camillo Ricordi, the guide of the institute, said the stick out is very exciting. "We're assembling all the pieces of the puzzle to replace the pancreas. Initially, we have to go in stages, and clinically examine the components of the BioHub. The first step is to test the scaffold assembly that will stir like a regular islet cell transplant".
The Diabetes Research Institute already successfully treats genre 1 diabetes with islet cell transplants into the liver. In type 1 diabetes, an autoimmune disease, the body's invulnerable system mistakenly attacks and destroys the beta cells contained within islet cells. This means someone with exemplar 1 diabetes can no longer put on the insulin they need to get sugar (glucose) to the body's cells, so they must replace the lost insulin.
This can be done only through multiple regular injections or with an insulin pump via a tiny tube inserted under the lamina and changed every few days. Although islet cell transplantation has been very successful in treating type 1 diabetes, the underlying autoimmune fitness is still there. Because transplanted cells come from cadaver donors, common people who have islet cell transplants must take immune-suppressing drugs to prevent rejection of the revitalized cells.
This puts people at risk of developing complications from the medication, and, over time, the protected system destroys the new islet cells. Because of these issues, islet cell transplantation is largely reserved for people whose diabetes is very difficult to control or who no longer have an awareness of potentially iffy low blood-sugar levels. Julia Greenstein, vice president of Cure Therapies for JDRF (formerly the Juvenile Diabetes Research Institute), said the risks of islet apartment transplantation currently overbalance the benefits for healthy people with type 1 diabetes.
A original bioengineered, microscopic organ dubbed the BioHub might one day offer people with variety 1 diabetes freedom from their disease. In its final stages, the BioHub would mimic a pancreas and work as a home for transplanted islet cells, providing them with oxygen until they could establish their own blood supply. Islet cells restrain beta cells, which are the cells that produce the hormone insulin. Insulin helps the body metabolize the carbohydrates found in foods so they can be in use as fuel for the body's cells. The BioHub also would give suppression of the immune system that would be confined to the area around the islet cells, or it's viable each islet cell might be encapsulated to protect it against the autoimmune attack that causes type 1 diabetes.
The beginning step, however, is to load islet cells into the BioHub and transplant it into an region of the abdomen known as the omentum. These trials are expected to begin within the next year or year and a half, said Dr Luca Inverardi, legate director of translational research at the Diabetes Research Institute at the University of Miami, where the BioHub is being developed.
Dr Camillo Ricordi, the guide of the institute, said the stick out is very exciting. "We're assembling all the pieces of the puzzle to replace the pancreas. Initially, we have to go in stages, and clinically examine the components of the BioHub. The first step is to test the scaffold assembly that will stir like a regular islet cell transplant".
The Diabetes Research Institute already successfully treats genre 1 diabetes with islet cell transplants into the liver. In type 1 diabetes, an autoimmune disease, the body's invulnerable system mistakenly attacks and destroys the beta cells contained within islet cells. This means someone with exemplar 1 diabetes can no longer put on the insulin they need to get sugar (glucose) to the body's cells, so they must replace the lost insulin.
This can be done only through multiple regular injections or with an insulin pump via a tiny tube inserted under the lamina and changed every few days. Although islet cell transplantation has been very successful in treating type 1 diabetes, the underlying autoimmune fitness is still there. Because transplanted cells come from cadaver donors, common people who have islet cell transplants must take immune-suppressing drugs to prevent rejection of the revitalized cells.
This puts people at risk of developing complications from the medication, and, over time, the protected system destroys the new islet cells. Because of these issues, islet cell transplantation is largely reserved for people whose diabetes is very difficult to control or who no longer have an awareness of potentially iffy low blood-sugar levels. Julia Greenstein, vice president of Cure Therapies for JDRF (formerly the Juvenile Diabetes Research Institute), said the risks of islet apartment transplantation currently overbalance the benefits for healthy people with type 1 diabetes.
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