An Approved Vaccine To Treat Prostate Cancer Has Few Side Effects.
The newly approved restorative prostate cancer vaccine, Provenge, is conservative and has few airs effects, a new study finds. In April, the US Food and Drug Administration approved the vaccine for use in men with advanced prostate cancer who had failed hormone therapy. "Provenge was approved based on both cover and clinical data," said prima donna researcher Dr Simon J Hall, bench of urology at Mount Sinai Medical Center in New York City.
This refuge data shows that there are very limited side effects. The superiority of the vaccine for patients with metastatic hormone-resistant prostate cancer is that it has fewer side stuff than chemotherapy, which is the only other treatment option for these patients. In addition, Provenge has improved survival over chemotherapy.
The mean survival time for men given Provenge is 4,5 months, although some patients saw their lives extended by two to three years. "This is a newly nearby treatment, with very limited standpoint effects, compared to anything else that a man would be considering in this state". Hall was to present the results on Monday at the American Urological Association annual convergence in San Francisco.
Data from four phase 3 trials, which included 904 men randomized to either Provenge or placebo, showed the vaccine extended survival, improved nobility of viability and had only mild side effects. In fact, more than 83 percent of the men who received Provenge were able to do appear as activities without any restrictions, the researchers noted.
Monday, 23 December 2019
Passive Smoking Increases The Risk Of Sinusitis
Passive Smoking Increases The Risk Of Sinusitis.
Exposure to secondhand smoke appears to sincerely foster the risk for chronic sinusitis, a new Canadian swotting has found. In fact, it might explain 40 percent of the cases of the condition, said muse about author Dr C Martin Tammemagi, a researcher at Brock University in Ontario. "The numbers surprised me somewhat. My imprecise impression was that public health agencies were strongly discouraging smoking and controlling secondhand smoke, and that governments in similarity were passing protective legislation to adjust peoples' exposure to secondhand smoke".
But his team found that more than 90 percent of those in the study who had hardened sinusitis and more than 84 percent of the comparison group, which did not have the condition, were exposed to secondhand smoke in following places. "To see that exposure to secondhand smoke was still common did surprise and alarm me".
The depraved effects of secondhand smoke have been well-documented, and experts know it contains more than 4,000 substances, including 50 or more known or suspected carcinogens and many basic irritants, according to Tammemagi. The identify with between secondhand smoke and sinusitis, however, has been little studied. "To date, there have not been any high-quality studies that have looked at this carefully" and then estimated the lines that smoke plays in the sinus problem.
In their study, the researchers evaluated reports of secondhand smoke danger in 306 nonsmokers who had chronic rhinosinusitis, defined as swelling of the nose or sinuses lasting 12 weeks or longer. The sinuses are cavities within the cheek bones, around the eyes and behind the nose that moisten and dribble air within the nasal cavity.
The researchers asked the participants about their risk to secondhand smoke for the five years before their diagnosis and then compared the responses with those of 306 consumers of similar age, sex and race who did not have the sinus problem. Those with sinusitis were more apt to than the comparison group to have been exposed to secondhand smoke not only in public places but at home, responsibility and private social functions, such as weddings, the researchers found.
Exposure to secondhand smoke appears to sincerely foster the risk for chronic sinusitis, a new Canadian swotting has found. In fact, it might explain 40 percent of the cases of the condition, said muse about author Dr C Martin Tammemagi, a researcher at Brock University in Ontario. "The numbers surprised me somewhat. My imprecise impression was that public health agencies were strongly discouraging smoking and controlling secondhand smoke, and that governments in similarity were passing protective legislation to adjust peoples' exposure to secondhand smoke".
But his team found that more than 90 percent of those in the study who had hardened sinusitis and more than 84 percent of the comparison group, which did not have the condition, were exposed to secondhand smoke in following places. "To see that exposure to secondhand smoke was still common did surprise and alarm me".
The depraved effects of secondhand smoke have been well-documented, and experts know it contains more than 4,000 substances, including 50 or more known or suspected carcinogens and many basic irritants, according to Tammemagi. The identify with between secondhand smoke and sinusitis, however, has been little studied. "To date, there have not been any high-quality studies that have looked at this carefully" and then estimated the lines that smoke plays in the sinus problem.
In their study, the researchers evaluated reports of secondhand smoke danger in 306 nonsmokers who had chronic rhinosinusitis, defined as swelling of the nose or sinuses lasting 12 weeks or longer. The sinuses are cavities within the cheek bones, around the eyes and behind the nose that moisten and dribble air within the nasal cavity.
The researchers asked the participants about their risk to secondhand smoke for the five years before their diagnosis and then compared the responses with those of 306 consumers of similar age, sex and race who did not have the sinus problem. Those with sinusitis were more apt to than the comparison group to have been exposed to secondhand smoke not only in public places but at home, responsibility and private social functions, such as weddings, the researchers found.
Saving Lives With Hemostatic Medicine
Saving Lives With Hemostatic Medicine.
A narcotize commonly employed to prevent excess bleeding in surgeries could keep thousands of people from bleeding to death after trauma, a unique study suggests. The drug, tranexamic acid (TXA) is cheap, greatly available around the world and easily administered. It works by significantly reducing the rate at which blood clots flout down, the researchers explained. "When people have serious injuries, whether from accidents or violence, and when they have fierce hemorrhage they can bleed to death.
This treatment reduces the chances of bleeding to death by about a sixth," said researcher Dr Ian Roberts, a professor of epidemiology at the London School of Hygiene and Tropical Medicine in the UK. According to Roberts, each year about 600000 society bleed to demise worldwide. "So, if you could bring down that by a sixth, you've saved 100000 lives in one year".
The report, which was on the whole funded by philanthropic groups and the British government, is published in the June 15 online issue of The Lancet. For the study, Roberts and colleagues in the CRASH-2 consortium randomly assigned more than 20000 trauma patients from 274 hospitals across 40 countries to injections of either TXA or placebo.
Among patients receiving TXA, the pace of expiry from any cause was cut by 10 percent compared to patients receiving placebo, the researchers found. In the TXA group, 14,5 percent of the patients died compared with 16 percent of the patients in the placebo group.
A narcotize commonly employed to prevent excess bleeding in surgeries could keep thousands of people from bleeding to death after trauma, a unique study suggests. The drug, tranexamic acid (TXA) is cheap, greatly available around the world and easily administered. It works by significantly reducing the rate at which blood clots flout down, the researchers explained. "When people have serious injuries, whether from accidents or violence, and when they have fierce hemorrhage they can bleed to death.
This treatment reduces the chances of bleeding to death by about a sixth," said researcher Dr Ian Roberts, a professor of epidemiology at the London School of Hygiene and Tropical Medicine in the UK. According to Roberts, each year about 600000 society bleed to demise worldwide. "So, if you could bring down that by a sixth, you've saved 100000 lives in one year".
The report, which was on the whole funded by philanthropic groups and the British government, is published in the June 15 online issue of The Lancet. For the study, Roberts and colleagues in the CRASH-2 consortium randomly assigned more than 20000 trauma patients from 274 hospitals across 40 countries to injections of either TXA or placebo.
Among patients receiving TXA, the pace of expiry from any cause was cut by 10 percent compared to patients receiving placebo, the researchers found. In the TXA group, 14,5 percent of the patients died compared with 16 percent of the patients in the placebo group.
Sports Prevents Breast Cancer
Sports Prevents Breast Cancer.
Vigorous make nervous on a regular basis might lend a hand protect black women against an aggressive form of breast cancer, researchers have found in Dec 2013. The unusual study included nearly 45000 black women, aged 30 and older, who were followed for nearly 20 years. Those who affianced in vigorous exercise for a lifetime average of three or more hours a week were 47 percent less in all probability to develop so-called estrogen receptor-negative breast cancer compared with those who exercised an common of one hour per week, the investigators found.
This type of bust cancer, which includes HER2-positive and triple-negative tumors, is linked to both higher incidence and death jeopardize in black women, compared to white women. These estrogen receptor-negative tumors do not return to the types of hormone therapies used to treat tumors that have the estrogen receptor, the researchers said in a Georgetown University Medical Center report release.
Vigorous make nervous on a regular basis might lend a hand protect black women against an aggressive form of breast cancer, researchers have found in Dec 2013. The unusual study included nearly 45000 black women, aged 30 and older, who were followed for nearly 20 years. Those who affianced in vigorous exercise for a lifetime average of three or more hours a week were 47 percent less in all probability to develop so-called estrogen receptor-negative breast cancer compared with those who exercised an common of one hour per week, the investigators found.
This type of bust cancer, which includes HER2-positive and triple-negative tumors, is linked to both higher incidence and death jeopardize in black women, compared to white women. These estrogen receptor-negative tumors do not return to the types of hormone therapies used to treat tumors that have the estrogen receptor, the researchers said in a Georgetown University Medical Center report release.
Very Few People Know How To Protect Yourself From Skin Cancer
Very Few People Know How To Protect Yourself From Skin Cancer.
A green subject survey by the American Academy of Dermatology finds that many subjects don't know enough about sun damage to protect themselves from developing skin cancer. "Our inspection showed that despite our repeated warnings about the dangers of UV exposure and the importance of proper Sunna protection, many people could not correctly answer true/false statements on the subject," said dermatologist Dr Zoe D Draelos, consulting professor at Duke University School of Medicine in Durham, NC, in a report release.
The assess found that only about one-third of more than 7000 people surveyed knew that neither ultraviolet A nor ultraviolet B rays are unharmed for your skin. "Quite simply, all forms of UV exposure, whether from not incongruous sunlight or artificial light sources found in tanning beds, are unsafe and are the No 1 preventable endanger factor for skin cancer".
A green subject survey by the American Academy of Dermatology finds that many subjects don't know enough about sun damage to protect themselves from developing skin cancer. "Our inspection showed that despite our repeated warnings about the dangers of UV exposure and the importance of proper Sunna protection, many people could not correctly answer true/false statements on the subject," said dermatologist Dr Zoe D Draelos, consulting professor at Duke University School of Medicine in Durham, NC, in a report release.
The assess found that only about one-third of more than 7000 people surveyed knew that neither ultraviolet A nor ultraviolet B rays are unharmed for your skin. "Quite simply, all forms of UV exposure, whether from not incongruous sunlight or artificial light sources found in tanning beds, are unsafe and are the No 1 preventable endanger factor for skin cancer".
Sunday, 22 December 2019
Living With HIV For People Over 50 Years
Living With HIV For People Over 50 Years.
One January broad daylight in 1991, business journalist Jane Fowler, then 55, opened a symbol from a health insurance company informing her that her request for coverage had been denied due to a "significant blood abnormality". This was the leading inkling - later confirmed in her doctor's office - that the Kansas City, Kan, first had contracted HIV from someone she had dated five years before, a male she'd been friends with her entire adult life. She had begun seeing him two years after the end of her 24-year marriage.
Fowler, now 75 and robust thanks to the advent of antiretroviral medications, recalls being devastated by her diagnosis. "I went deeply that day and literally took to my bed. I thought, 'What's successful to happen?'" she said. For the next four years Fowler, once an active and thriving writer and editor, lived in what she called "semi-isolation," staying mostly in her apartment. Then came the dawning perception that her isolation wasn't helping anyone, least of all herself.
Fowler slowly began reaching out to experts and other older Americans to acquire knowledge more about living with HIV in life's later decades. By 1995, she had helped co-found the National Association on HIV Over 50. And through her program, HIV Wisdom for Older Women, Fowler today speaks to audiences nationwide on the challenges of living with the virus. "I obvious to discourse out - to put an old, wrinkled, white, heterosexual pretence to this disease. But my import isn't age-specific: We all need to understand that we can be at risk".
That point may be more urgent than ever this Wednesday, World AIDS Day. During a recent White House forum on HIV and aging, at which Fowler spoke, experts presented unfamiliar data suggesting that as the HIV/AIDS rash enters its fourth decade those afflicted by it are aging, too.
One report, conducted by the AIDS Community Research Initiative of America (ACRIA), esteemed that 27 percent of Americans diagnosed with HIV are now age-old 50 or older and by 2015 that percentage could double. Why? According to Dr Michael Horberg, evil chair of the HIV Medicine Association, there's been a societal "perfect storm" that's led to more HIV infections amid people in middle age or older.
And "Certainly the happen of Viagra and similar drugs to treat erectile dysfunction, people are getting more sexually working because they are more able to do so". There's also the perception that HIV is now treatable with complex drug regimens even though these medicines often come with onerous string effects. For her part, Fowler said that more and more aging Americans think themselves recently divorced (as she did) or widowed and back in the dating game.
One January broad daylight in 1991, business journalist Jane Fowler, then 55, opened a symbol from a health insurance company informing her that her request for coverage had been denied due to a "significant blood abnormality". This was the leading inkling - later confirmed in her doctor's office - that the Kansas City, Kan, first had contracted HIV from someone she had dated five years before, a male she'd been friends with her entire adult life. She had begun seeing him two years after the end of her 24-year marriage.
Fowler, now 75 and robust thanks to the advent of antiretroviral medications, recalls being devastated by her diagnosis. "I went deeply that day and literally took to my bed. I thought, 'What's successful to happen?'" she said. For the next four years Fowler, once an active and thriving writer and editor, lived in what she called "semi-isolation," staying mostly in her apartment. Then came the dawning perception that her isolation wasn't helping anyone, least of all herself.
Fowler slowly began reaching out to experts and other older Americans to acquire knowledge more about living with HIV in life's later decades. By 1995, she had helped co-found the National Association on HIV Over 50. And through her program, HIV Wisdom for Older Women, Fowler today speaks to audiences nationwide on the challenges of living with the virus. "I obvious to discourse out - to put an old, wrinkled, white, heterosexual pretence to this disease. But my import isn't age-specific: We all need to understand that we can be at risk".
That point may be more urgent than ever this Wednesday, World AIDS Day. During a recent White House forum on HIV and aging, at which Fowler spoke, experts presented unfamiliar data suggesting that as the HIV/AIDS rash enters its fourth decade those afflicted by it are aging, too.
One report, conducted by the AIDS Community Research Initiative of America (ACRIA), esteemed that 27 percent of Americans diagnosed with HIV are now age-old 50 or older and by 2015 that percentage could double. Why? According to Dr Michael Horberg, evil chair of the HIV Medicine Association, there's been a societal "perfect storm" that's led to more HIV infections amid people in middle age or older.
And "Certainly the happen of Viagra and similar drugs to treat erectile dysfunction, people are getting more sexually working because they are more able to do so". There's also the perception that HIV is now treatable with complex drug regimens even though these medicines often come with onerous string effects. For her part, Fowler said that more and more aging Americans think themselves recently divorced (as she did) or widowed and back in the dating game.
Saturday, 21 December 2019
Many Survivors Of Lymphoma Did Not Receive A Recommendation To Take Further Tests For Other Types Of Cancer
Many Survivors Of Lymphoma Did Not Receive A Recommendation To Take Further Tests For Other Types Of Cancer.
Many Hodgkin lymphoma survivors don't notified of recommended bolstering screening tests for other cancers, a restored reflect on finds. "Most Hodgkin lymphoma patients are cured, but they can be at risk many years later of developing unessential cancers or other late effects of their initial treatment. This is why prominence of follow-up care post-treatment is so important," principal investigator Dr David Hodgson, a emanation oncologist at the Princess Margaret Hospital Cancer Program in Toronto, Canada, said in a University Health Network dispatch release.
He and his colleagues followed 2071 survivors for up to 15 years after Hodgkin lymphoma diagnosis and found that 62,5 percent were not screened for colorectal cancer, 32,3 percent were not screened for soul cancer, and 19,9 percent were not screened for cervical cancer. "Our results disclose that the optimal reinforcement care did not happen, even though most patients had visits with both a primary care provider and an oncologist in years two through five.
Many Hodgkin lymphoma survivors don't notified of recommended bolstering screening tests for other cancers, a restored reflect on finds. "Most Hodgkin lymphoma patients are cured, but they can be at risk many years later of developing unessential cancers or other late effects of their initial treatment. This is why prominence of follow-up care post-treatment is so important," principal investigator Dr David Hodgson, a emanation oncologist at the Princess Margaret Hospital Cancer Program in Toronto, Canada, said in a University Health Network dispatch release.
He and his colleagues followed 2071 survivors for up to 15 years after Hodgkin lymphoma diagnosis and found that 62,5 percent were not screened for colorectal cancer, 32,3 percent were not screened for soul cancer, and 19,9 percent were not screened for cervical cancer. "Our results disclose that the optimal reinforcement care did not happen, even though most patients had visits with both a primary care provider and an oncologist in years two through five.
Treatment Of Severe Acne May Increase Risk Of Suicide Attempts
Treatment Of Severe Acne May Increase Risk Of Suicide Attempts.
Severe acne may significantly enhancement suicide risk, and patients taking isotretinoin (Accutane) for the pellicle influence should be monitored for at least a year after treatment ends, Swedish researchers report. "Treatment with Accutane truly entails an increased risk of suicide attempts," said lead researcher Anders Sundstrom, a pharmacoepidemiologist at the Karolinska Institute in Stockholm. However, recess caused by the acne, rather than the hypnotic itself, is probably the culprit.
The risk of suicide is very small. There could be one suicide go among 2300 people taking Accutane, and that assumes that the drug caused the suicide attempt. For the study, published online Nov 12,2010 in BMJ, Sundstrom's gang collected matter on 5756 people treated for severe acne with Accutane from 1980 to 1989. The middling age of the men was 22; the average age of women was 27.
Linking these patients to hospitalization and ruin records from 1980 to 2001, they found that 128 of the patients were hospitalized because of a suicide attempt. Suicide attempts increased in the several years before Accutane was started, but the highest gamble was seen in the six months after treatment ended, Sundstrom's collection found.
It's possible that patients whose skin improved became distraught if their social biography didn't benefit, the researchers speculated. Also, Accutane takes time to work and acne can get worse before it gets better. "It takes a long time to get rid of the acne, and for the self-image to get better might bilk even a longer time".
Severe acne may significantly enhancement suicide risk, and patients taking isotretinoin (Accutane) for the pellicle influence should be monitored for at least a year after treatment ends, Swedish researchers report. "Treatment with Accutane truly entails an increased risk of suicide attempts," said lead researcher Anders Sundstrom, a pharmacoepidemiologist at the Karolinska Institute in Stockholm. However, recess caused by the acne, rather than the hypnotic itself, is probably the culprit.
The risk of suicide is very small. There could be one suicide go among 2300 people taking Accutane, and that assumes that the drug caused the suicide attempt. For the study, published online Nov 12,2010 in BMJ, Sundstrom's gang collected matter on 5756 people treated for severe acne with Accutane from 1980 to 1989. The middling age of the men was 22; the average age of women was 27.
Linking these patients to hospitalization and ruin records from 1980 to 2001, they found that 128 of the patients were hospitalized because of a suicide attempt. Suicide attempts increased in the several years before Accutane was started, but the highest gamble was seen in the six months after treatment ended, Sundstrom's collection found.
It's possible that patients whose skin improved became distraught if their social biography didn't benefit, the researchers speculated. Also, Accutane takes time to work and acne can get worse before it gets better. "It takes a long time to get rid of the acne, and for the self-image to get better might bilk even a longer time".
Efficiency Of Breast-Feeding On Brain Activity Of The Baby
Efficiency Of Breast-Feeding On Brain Activity Of The Baby.
Breast-feeding is excellent for a baby's brain, a unexplored study says in June 2013. Researchers employed MRI scans to examine brain growth in 133 children ranging in ripen from 10 months to 4 years. By age 2, babies who were breast-fed exclusively for at least three months had greater levels of occurrence in key parts of the brain than those who were fed formulary only or a combination of formula and breast milk. The extra growth was most evident in parts of the knowledge associated with things such as language, emotional function and thinking skills, according to the study published online May 28 in the register NeuroImage.
So "We're finding the difference in white question growth is on the order of 20 to 30 percent, comparing the breast-fed and the non-breast-fed kids," consider author Sean Deoni, an assistant professor of engineering at Brown University, said in a university communication release. "I think it's astounding that you could have that much difference so early".
Breast-feeding is excellent for a baby's brain, a unexplored study says in June 2013. Researchers employed MRI scans to examine brain growth in 133 children ranging in ripen from 10 months to 4 years. By age 2, babies who were breast-fed exclusively for at least three months had greater levels of occurrence in key parts of the brain than those who were fed formulary only or a combination of formula and breast milk. The extra growth was most evident in parts of the knowledge associated with things such as language, emotional function and thinking skills, according to the study published online May 28 in the register NeuroImage.
So "We're finding the difference in white question growth is on the order of 20 to 30 percent, comparing the breast-fed and the non-breast-fed kids," consider author Sean Deoni, an assistant professor of engineering at Brown University, said in a university communication release. "I think it's astounding that you could have that much difference so early".
Newer Blood Thinner Brilinta Exceeds Plavix For Cardiac Bypass Surgery Patients
Newer Blood Thinner Brilinta Exceeds Plavix For Cardiac Bypass Surgery Patients.
In a examination comparing two anti-clotting drugs, patients given Brilinta before cardiac get round surgery were less qualified to die than those given Plavix, researchers found. Both drugs restrain platelets from clumping and forming clots, but Plavix, the more popular drug, has been linked to potentially treacherous side effects in cancer patients.
In addition, some people don't metabolize it well, making it less effective. "We did perceive about a 50 percent reduction in mortality in these patients, who took Brilinta, but without any further in bleeding complications," Dr Claes Held, an associate professor of cardiology at the Uppsala Clinical Research Center at Uppsala University in Sweden and the study's clue researcher, said during an afternoon cleave to conference Tuesday.
So "Ticagrelor (Brilinta) in this setting, with acute coronary syndrome patients with the likely need for bypass surgery, is more effective than clopidogrel (Plavix) in preventing cardiovascular and thorough mortality without increasing the risk of bleeding". A danger with any anti-platelet hypnotic is the risk of uncontrolled bleeding, which is why these drugs are stopped before patients undergo surgery.
Held was scheduled to acquaint with the results Tuesday at the American College of Cardiology's annual meeting in Atlanta. For the study, Held and colleagues looked at a subgroup of 1261 patients in the Platelet Inhibition and Patient Outcomes (PLATO) trial. The researchers found that 10,5 percent of the patients given Brilinta with an increment of aspirin before surgery had a heartlessness attack, work or died from heart disease within a week after surgery. Among patients given Plavix profit aspirin, 12,6 percent had the same adverse outcomes.
Patients taking Brilinta had a unqualified death rate of 4,6 percent, compared with 9,2 percent for patients taking Plavix. In addition, the cardiovascular extirpation rates were 4 percent among patients taking Brilinta and 7,5 percent amidst those taking Plavix. When Held's team looked at each group individually, they found no statistically significant characteristic for heart attack and stroke and no significant difference in major bleeding from the bypass operation itself. The two drugs farm in different ways.
In a examination comparing two anti-clotting drugs, patients given Brilinta before cardiac get round surgery were less qualified to die than those given Plavix, researchers found. Both drugs restrain platelets from clumping and forming clots, but Plavix, the more popular drug, has been linked to potentially treacherous side effects in cancer patients.
In addition, some people don't metabolize it well, making it less effective. "We did perceive about a 50 percent reduction in mortality in these patients, who took Brilinta, but without any further in bleeding complications," Dr Claes Held, an associate professor of cardiology at the Uppsala Clinical Research Center at Uppsala University in Sweden and the study's clue researcher, said during an afternoon cleave to conference Tuesday.
So "Ticagrelor (Brilinta) in this setting, with acute coronary syndrome patients with the likely need for bypass surgery, is more effective than clopidogrel (Plavix) in preventing cardiovascular and thorough mortality without increasing the risk of bleeding". A danger with any anti-platelet hypnotic is the risk of uncontrolled bleeding, which is why these drugs are stopped before patients undergo surgery.
Held was scheduled to acquaint with the results Tuesday at the American College of Cardiology's annual meeting in Atlanta. For the study, Held and colleagues looked at a subgroup of 1261 patients in the Platelet Inhibition and Patient Outcomes (PLATO) trial. The researchers found that 10,5 percent of the patients given Brilinta with an increment of aspirin before surgery had a heartlessness attack, work or died from heart disease within a week after surgery. Among patients given Plavix profit aspirin, 12,6 percent had the same adverse outcomes.
Patients taking Brilinta had a unqualified death rate of 4,6 percent, compared with 9,2 percent for patients taking Plavix. In addition, the cardiovascular extirpation rates were 4 percent among patients taking Brilinta and 7,5 percent amidst those taking Plavix. When Held's team looked at each group individually, they found no statistically significant characteristic for heart attack and stroke and no significant difference in major bleeding from the bypass operation itself. The two drugs farm in different ways.
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