Scanning The Human Genome Provide Insights Into The Likelihood Of Future Disease.
Stephen Quake, a Stanford University professor of bioengineering, now has a very virtuous atmosphere of his own genetic destiny. Quake's DNA was the focal point of the first completely mapped genome of a tonic person aimed at predicting future health risks. The scrutinize was conducted by a team of Stanford researchers and cost about $50,000. The researchers say they can now augur Quake's risk for dozens of diseases and how he might respond to a number of widely used medicines.
This breed of individualized risk report could become common within the next decade and may become much cheaper, according to the Stanford team. "The $1000 genome evaluation is coming fast. The challenge lies in knowing what to do with all that information. We've focused on establishing priorities that will be most kind when a patient and a physician are sitting together looking at the computer screen," Euan Ashley, an helpmate professor of medicine, said in a university news release.
Those priorities count assessing how a person's activity levels, weight, diet and other lifestyle habits pool with his or her genetic risk for, or protection against, health problems such as diabetes or ticker attack. It's also important to determine if a certain medication is likely to benefit the patient or cause detrimental side effects.
"We're at the dawn of a new age in genomics. Information like this will enable doctors to transfer personalized health care like never before. Patients at risk for certain diseases will be able to welcome closer monitoring and more frequent testing, while those who are at lower risk will be spared unnecessary tests. This will have consequential economic benefits as well, because it improves the efficiency of medicine".
Sunday, 8 December 2019
Incidence Of Lung Cancer In Black Men Is Higher Than The National Average
Incidence Of Lung Cancer In Black Men Is Higher Than The National Average.
Despite above-named findings to the contrary, unfamiliar inspect indicates that black patients with non-small cell lung are as likely to harbor a specific anomaly in tumors as white patients. This means that black patients should be at least as likely as white patients to improve from highly effective therapies that target the mutation, such as the drug known as erlotinib, the researchers said. "This ruminate on has immediate implications for patient management," Ramsi Haddad, kingpin of the Laboratory of Translational Oncogenomics at the Barbara Ann Karmanos Cancer Institute in Detroit, said in a tidings release from the American Association for Cancer Research.
The mutation involves the epidermal tumour factor receptor (EGFR) protein, which is seen in abnormally high numbers on the surface of cancer cells and associated with cancer spread. EGFR mutations swell the tumor's sensitivity to certain medications designed to shrivel tumors and slow progress of the disease, previous research has found. "Patients with EGFR mutations have a much better prophecy and respond better to erlotinib than those who do not," explained Haddad, who is also an assistant professor at Wayne State University School of Medicine.
Haddad and his colleagues were scheduled to distribute their findings Tuesday in Denver at the American Association for Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development. The researchers mucroniform out that sombre men in particular have a higher than so so incidence of lung cancer. In addition, when diagnosed, black patients generally expression worse outcomes than white patients. Prior research, the scientists said, suggested that this imparity in prognosis might be driven by a lower occurrence of EGFR mutations among black patients.
Despite above-named findings to the contrary, unfamiliar inspect indicates that black patients with non-small cell lung are as likely to harbor a specific anomaly in tumors as white patients. This means that black patients should be at least as likely as white patients to improve from highly effective therapies that target the mutation, such as the drug known as erlotinib, the researchers said. "This ruminate on has immediate implications for patient management," Ramsi Haddad, kingpin of the Laboratory of Translational Oncogenomics at the Barbara Ann Karmanos Cancer Institute in Detroit, said in a tidings release from the American Association for Cancer Research.
The mutation involves the epidermal tumour factor receptor (EGFR) protein, which is seen in abnormally high numbers on the surface of cancer cells and associated with cancer spread. EGFR mutations swell the tumor's sensitivity to certain medications designed to shrivel tumors and slow progress of the disease, previous research has found. "Patients with EGFR mutations have a much better prophecy and respond better to erlotinib than those who do not," explained Haddad, who is also an assistant professor at Wayne State University School of Medicine.
Haddad and his colleagues were scheduled to distribute their findings Tuesday in Denver at the American Association for Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development. The researchers mucroniform out that sombre men in particular have a higher than so so incidence of lung cancer. In addition, when diagnosed, black patients generally expression worse outcomes than white patients. Prior research, the scientists said, suggested that this imparity in prognosis might be driven by a lower occurrence of EGFR mutations among black patients.
Shoveling Snow Leads To Death
Shoveling Snow Leads To Death.
Shoveling snow can snowball your imperil of heart attack, and you should take precautions to protect yourself, an expert says. "When the temperature front drops, our blood vessels narrow to prevent our bodies from losing heat," Dr Holly Andersen, gaffer of education and outreach at the Ronald O Perelman Heart Institute of NewYork-Presbyterian Hospital/Weill Cornell Medical Center, said in a dispensary news release. "This is a fool response that can also put people with heart conditions and those involved in strenuous exercise at greater peril of having a heart attack".
Andersen said shoveling snow is one of the most strenuous and dangerous winter activities. It can leg up blood pressure and, combined with the effects of frigid temperatures, can significantly proliferate heart attack risk. Andersen offered the following advice for safe shoveling and good courage health this winter.
Shoveling snow can snowball your imperil of heart attack, and you should take precautions to protect yourself, an expert says. "When the temperature front drops, our blood vessels narrow to prevent our bodies from losing heat," Dr Holly Andersen, gaffer of education and outreach at the Ronald O Perelman Heart Institute of NewYork-Presbyterian Hospital/Weill Cornell Medical Center, said in a dispensary news release. "This is a fool response that can also put people with heart conditions and those involved in strenuous exercise at greater peril of having a heart attack".
Andersen said shoveling snow is one of the most strenuous and dangerous winter activities. It can leg up blood pressure and, combined with the effects of frigid temperatures, can significantly proliferate heart attack risk. Andersen offered the following advice for safe shoveling and good courage health this winter.
Saturday, 7 December 2019
Regular Exercise Slows Down Aging
Regular Exercise Slows Down Aging.
People who devotedly exercise during their younger years, especially women, are less qualified to face the battle of the bulge that less-consistent types struggle with, researchers say. But approved exercise while young only appeared to prevent later preponderance gain if it reached about 150 minutes of moderate to vigorous physical activity a week, such as running, sybaritic walking, basketball, exercise classes or daily activities like housework, according to a cramming in the Dec 15, 2010 issue of the Journal of the American Medical Association.
This is the amount of corporeal activity recommended by the US Department of Health and Human Services. "This encourages the crowd to stick with their active lifestyle and a program of activity over decades," said study lead initiator Dr Arlene L Hankinson, an instructor in the department of preventive medicine at Northwestern University's Feinberg School of Medicine in Chicago, noting that the on covered 20 years. "It's outstanding to start young and to stay active but that doesn't mean you can't change. It just may be harder to also gaol the weight off when you get to be middle-aged," said Marcia G Ory, a Regents professor of group and behavioral health and director of the Aging and Health Promotion Program at Texas A&M Health Science Center School of Rural Public Health in College Station, Texas.
Most of today's enquiry focuses on losing weight, not preventing force gain in the first place. To winnow the latter, this study followed 3,554 men and women aged 18 to 30 at the origin of the study, for 20 years. Participants lived in one of four urban areas in the United States: Chicago, Illinois; Birmingham, Alabama; Minneapolis, Minnesota; and Oakland, California.
After adjusting for various factors such as seniority and power intake, men who maintained a high activity level gained an run-of-the-mill of 5,7 fewer pounds and women with a high activity level put on 13,4 fewer pounds than their counterparts who exercised less or who didn't operation consistently over the 20-year period. Much of that profit was seen around the waist, with high-activity men gaining 3,1 fewer centimeters (1,2 inches) around the abdomen each year and women 3,8 fewer centimeters (1,5 inches) per year.
People who devotedly exercise during their younger years, especially women, are less qualified to face the battle of the bulge that less-consistent types struggle with, researchers say. But approved exercise while young only appeared to prevent later preponderance gain if it reached about 150 minutes of moderate to vigorous physical activity a week, such as running, sybaritic walking, basketball, exercise classes or daily activities like housework, according to a cramming in the Dec 15, 2010 issue of the Journal of the American Medical Association.
This is the amount of corporeal activity recommended by the US Department of Health and Human Services. "This encourages the crowd to stick with their active lifestyle and a program of activity over decades," said study lead initiator Dr Arlene L Hankinson, an instructor in the department of preventive medicine at Northwestern University's Feinberg School of Medicine in Chicago, noting that the on covered 20 years. "It's outstanding to start young and to stay active but that doesn't mean you can't change. It just may be harder to also gaol the weight off when you get to be middle-aged," said Marcia G Ory, a Regents professor of group and behavioral health and director of the Aging and Health Promotion Program at Texas A&M Health Science Center School of Rural Public Health in College Station, Texas.
Most of today's enquiry focuses on losing weight, not preventing force gain in the first place. To winnow the latter, this study followed 3,554 men and women aged 18 to 30 at the origin of the study, for 20 years. Participants lived in one of four urban areas in the United States: Chicago, Illinois; Birmingham, Alabama; Minneapolis, Minnesota; and Oakland, California.
After adjusting for various factors such as seniority and power intake, men who maintained a high activity level gained an run-of-the-mill of 5,7 fewer pounds and women with a high activity level put on 13,4 fewer pounds than their counterparts who exercised less or who didn't operation consistently over the 20-year period. Much of that profit was seen around the waist, with high-activity men gaining 3,1 fewer centimeters (1,2 inches) around the abdomen each year and women 3,8 fewer centimeters (1,5 inches) per year.
A Person Can Be Their Own Donor Cells For Insulin Production
A Person Can Be Their Own Donor Cells For Insulin Production.
Researchers have been able to dig sympathetic cells that normally produce sperm to form insulin instead and, after transplanting them, the cells briefly cured mice with font 1 diabetes. "The goal is to coax these cells into making enough insulin to cure diabetes. These cells don't extravasate enough insulin to cure diabetes in humans yet," cautioned on senior researcher G Ian Gallicano, an associate professor in the department of Biochemistry and Molecular and Cellular Biology, and kingpin of the Transgenic Core Facility at Georgetown University Medical Center, in Washington DC.
Gallicano and his colleagues will be presenting the findings Sunday at the American Society of Cell Biology annual conjunction in Philadelphia. Type 1 diabetes is believed to be an autoimmune complaint in which the body mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, men and women with classification 1 diabetes must rely on insulin injections to be able to process the foods they eat. Without this additional insulin, clan with type 1 diabetes could not survive.
Doctors have had some success with pancreas transplants, and with transplants of just the pancreatic beta cells (also known as islet cells). There are several problems with these types of transplants, however. One is that as with any transplant, when the transplanted tangible comes from a donor, the body sees the untrained combination as foreign and attempts to destroy it. So, transplants require immune-suppressing medications. The other involve is that the autoimmune attack that destroyed the original beta cells can spoil the newly transplanted cells.
A benefit of the technique developed by Gallicano and his team is that the cells are coming from the same man they'll be transplanted in, so the body won't see the cells as foreign. The researchers Euphemistic pre-owned spermatogonial cells, extracted from the testicles of deceased human organ donors. In the testes, the affair of these cells is to produce sperm, according to Gallicano.
However, outside of the testes the cells act a lot like human eggs do, and there are certain genes that turn them on and make them behave have a weakness for embryonic-like stem cells. "Once you take them out of their niche, the genes are primed and ready to go".
Researchers have been able to dig sympathetic cells that normally produce sperm to form insulin instead and, after transplanting them, the cells briefly cured mice with font 1 diabetes. "The goal is to coax these cells into making enough insulin to cure diabetes. These cells don't extravasate enough insulin to cure diabetes in humans yet," cautioned on senior researcher G Ian Gallicano, an associate professor in the department of Biochemistry and Molecular and Cellular Biology, and kingpin of the Transgenic Core Facility at Georgetown University Medical Center, in Washington DC.
Gallicano and his colleagues will be presenting the findings Sunday at the American Society of Cell Biology annual conjunction in Philadelphia. Type 1 diabetes is believed to be an autoimmune complaint in which the body mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, men and women with classification 1 diabetes must rely on insulin injections to be able to process the foods they eat. Without this additional insulin, clan with type 1 diabetes could not survive.
Doctors have had some success with pancreas transplants, and with transplants of just the pancreatic beta cells (also known as islet cells). There are several problems with these types of transplants, however. One is that as with any transplant, when the transplanted tangible comes from a donor, the body sees the untrained combination as foreign and attempts to destroy it. So, transplants require immune-suppressing medications. The other involve is that the autoimmune attack that destroyed the original beta cells can spoil the newly transplanted cells.
A benefit of the technique developed by Gallicano and his team is that the cells are coming from the same man they'll be transplanted in, so the body won't see the cells as foreign. The researchers Euphemistic pre-owned spermatogonial cells, extracted from the testicles of deceased human organ donors. In the testes, the affair of these cells is to produce sperm, according to Gallicano.
However, outside of the testes the cells act a lot like human eggs do, and there are certain genes that turn them on and make them behave have a weakness for embryonic-like stem cells. "Once you take them out of their niche, the genes are primed and ready to go".
Visiting Nurse Improves Intelligence
Visiting Nurse Improves Intelligence.
Poor children get sage and behavioral benefits from accommodations visits by nurses and other skilled caregivers, new research suggests. The writing-room included more than 700 poor women and their children in Denver who enrolled in a non-profit program called the Nurse-Family Partnership. This inhabitant program tries to improve outcomes for first-born children of first-time mothers with circumscribed support.
The goal of the study, which was published online recently in the album JAMA Pediatrics, was to determine the effectiveness of using trained "paraprofessionals". These professionals did not need college swotting and they shared many of the same social characteristics of the families they visited. The women in the study were divided into three groups.
Poor children get sage and behavioral benefits from accommodations visits by nurses and other skilled caregivers, new research suggests. The writing-room included more than 700 poor women and their children in Denver who enrolled in a non-profit program called the Nurse-Family Partnership. This inhabitant program tries to improve outcomes for first-born children of first-time mothers with circumscribed support.
The goal of the study, which was published online recently in the album JAMA Pediatrics, was to determine the effectiveness of using trained "paraprofessionals". These professionals did not need college swotting and they shared many of the same social characteristics of the families they visited. The women in the study were divided into three groups.
Flu Season This Year Began At Christmas
Flu Season This Year Began At Christmas.
In Chicago, a dispensary staff member describes the emergency department as "knee-deep in flu and pneumonia cases". In Richmond, VA, Dr Kenneth Lucas of the Patient First clinic says he's seen a 30 percent hillock in flu cases, which "hit the booster around Christmastime" and "really rolled in with the holidays". And in Rhode Island, where almost 10 percent of danger room visits in the olden times week were due to flu-like symptoms, state Health Department Director Michael Fine predicts this could be the worst flu ripen in years. This year's influenza season got off to an early start, and according to these and other published accounts it's ramping up as apogee flu season nears.
And "as we have moved into the end of December and January, venture has really picked up in a lot more states," said Tom Skinner, spokesman for the US Centers for Disease Control and Prevention. Flu period usually peaks in recently January or early February but by November the flu was already severe and widespread in some parts of the South and Southeast.
Farther north, occupation has escalated in the Mid-Atlantic states, including Virginia, in addition to Illinois and Rhode Island. "We did get off to an earlier start-up than we usually see". According to the most recent CDC statistics, aftermost updated Dec 22, 2012 16 states and New York City were reporting on a trip levels of flu activity. The states include Alabama, Georgia, Illinois, Indiana, Louisiana, Minnesota, Mississippi, Missouri, New Jersey, North Carolina, Ohio, South Carolina, Tennessee, Texas, Utah, and Virginia.
In Chicago, a dispensary staff member describes the emergency department as "knee-deep in flu and pneumonia cases". In Richmond, VA, Dr Kenneth Lucas of the Patient First clinic says he's seen a 30 percent hillock in flu cases, which "hit the booster around Christmastime" and "really rolled in with the holidays". And in Rhode Island, where almost 10 percent of danger room visits in the olden times week were due to flu-like symptoms, state Health Department Director Michael Fine predicts this could be the worst flu ripen in years. This year's influenza season got off to an early start, and according to these and other published accounts it's ramping up as apogee flu season nears.
And "as we have moved into the end of December and January, venture has really picked up in a lot more states," said Tom Skinner, spokesman for the US Centers for Disease Control and Prevention. Flu period usually peaks in recently January or early February but by November the flu was already severe and widespread in some parts of the South and Southeast.
Farther north, occupation has escalated in the Mid-Atlantic states, including Virginia, in addition to Illinois and Rhode Island. "We did get off to an earlier start-up than we usually see". According to the most recent CDC statistics, aftermost updated Dec 22, 2012 16 states and New York City were reporting on a trip levels of flu activity. The states include Alabama, Georgia, Illinois, Indiana, Louisiana, Minnesota, Mississippi, Missouri, New Jersey, North Carolina, Ohio, South Carolina, Tennessee, Texas, Utah, and Virginia.
Friday, 6 December 2019
The Use Of Colonoscopy Reduces The Risk Of Colon Cancer
The Use Of Colonoscopy Reduces The Risk Of Colon Cancer.
In annexe to reducing the danger of cancer on the left side of the colon, strange research indicates that colonoscopies may also reduce cancer risk on the right side. The judgement contradicts some previous research that had indicated a right-side "blind spots" when conducting colonoscopies. However, the right-side better shown in the new study, published in the Jan 4, 2011 issue of the Annals of Internal Medicine, was somewhat less effective than that seen on the left side.
And "We didn't really have able-bodied data proving that anything is very good at preventing right-sided cancer," said Dr Vivek Kaul, acting ranking of gastroenterology and hepatology at the University of Rochester Medical Center. "Here is a thesis that suggests that risk reduction is pretty robust even in the right side. The imperil reduction is not as exciting as in the left side, but it's still more than 50 percent. That's a little tyrannical to ignore".
The news is "reassuring," agreed Dr David Weinberg, chairman of medicine at Fox Chase Cancer Center in Philadelphia, who wrote an accompanying article on the finding. Though no one bookwork ever provides definitive proof "if the data from this study is in fact true, then this gives strong countenance for current guidelines".
The American Cancer Society recommends that normal-risk men and women be screened for colon cancer, starting at era 50. A colonoscopy once every 10 years is one of the recommended screening tools. However, there has been some contend as to whether colonoscopy - an invasive and expensive procedure - is absolutely preferable to other screening methods, such as flexible sigmoidoscopy.
In annexe to reducing the danger of cancer on the left side of the colon, strange research indicates that colonoscopies may also reduce cancer risk on the right side. The judgement contradicts some previous research that had indicated a right-side "blind spots" when conducting colonoscopies. However, the right-side better shown in the new study, published in the Jan 4, 2011 issue of the Annals of Internal Medicine, was somewhat less effective than that seen on the left side.
And "We didn't really have able-bodied data proving that anything is very good at preventing right-sided cancer," said Dr Vivek Kaul, acting ranking of gastroenterology and hepatology at the University of Rochester Medical Center. "Here is a thesis that suggests that risk reduction is pretty robust even in the right side. The imperil reduction is not as exciting as in the left side, but it's still more than 50 percent. That's a little tyrannical to ignore".
The news is "reassuring," agreed Dr David Weinberg, chairman of medicine at Fox Chase Cancer Center in Philadelphia, who wrote an accompanying article on the finding. Though no one bookwork ever provides definitive proof "if the data from this study is in fact true, then this gives strong countenance for current guidelines".
The American Cancer Society recommends that normal-risk men and women be screened for colon cancer, starting at era 50. A colonoscopy once every 10 years is one of the recommended screening tools. However, there has been some contend as to whether colonoscopy - an invasive and expensive procedure - is absolutely preferable to other screening methods, such as flexible sigmoidoscopy.
Treatment Of Diabetes Is Different For Men And Women
Treatment Of Diabetes Is Different For Men And Women.
Widely hand-me-down diabetes drugs have particular effects on men's and women's hearts, a rejuvenated study suggests. Researchers examined how three commonly prescribed treatments for type 2 diabetes laid hold of 78 patients who were divided into three groups. One group took metformin alone, the subsequent group took metformin plus rosiglitazone (sold under the maker name Avandia) and the third group took metformin plus Lovaza, a type of fish oil. Metformin reduces blood sugar assembly by the liver and improves insulin sensitivity.
Rosiglitazone also improves insulin consciousness and moves free fatty acids out of the blood. Lovaza lowers blood levels of another classification of fat called triglycerides. The researchers found that the drugs had very several and sometimes opposite effects on the hearts of men and women, even as the drugs controlled blood sugar equally well in both genders. The reading appears in the December issue of the American Journal of Physiology - Heart and Circulatory Physiology.
Widely hand-me-down diabetes drugs have particular effects on men's and women's hearts, a rejuvenated study suggests. Researchers examined how three commonly prescribed treatments for type 2 diabetes laid hold of 78 patients who were divided into three groups. One group took metformin alone, the subsequent group took metformin plus rosiglitazone (sold under the maker name Avandia) and the third group took metformin plus Lovaza, a type of fish oil. Metformin reduces blood sugar assembly by the liver and improves insulin sensitivity.
Rosiglitazone also improves insulin consciousness and moves free fatty acids out of the blood. Lovaza lowers blood levels of another classification of fat called triglycerides. The researchers found that the drugs had very several and sometimes opposite effects on the hearts of men and women, even as the drugs controlled blood sugar equally well in both genders. The reading appears in the December issue of the American Journal of Physiology - Heart and Circulatory Physiology.
Excessive Consumption Of Diet Drinks Can Cause To Depression
Excessive Consumption Of Diet Drinks Can Cause To Depression.
Older adults who down several house drinks a epoch may have a heightened risk of developing depression, a unfamiliar study suggests. Researchers found that of more than 260000 older adults in a US survey, those who had at least four everyday servings of artificially sweetened soda, iced tea or fruit punch were at increased jeopardize of being diagnosed with depression in the next decade. People with a taste for sugar-sweetened drinks also showed a higher recession risk versus those who avoided the beverages. But the link was weaker than the one between diet drinks and depression, according to the study, which was released Jan 8, 2013.
On the other hand, coffee lovers had a minor extent crop depression risk than people who typically passed on the java. What it all means, however, is anyone's guess. "This unquestionably creates more questions than it answers," said Eva Redei, a professor of psychiatry at the Northwestern University Feinberg School of Medicine in Chicago. And it unquestionably is not doable to lay the blame on diet drinks themselves, based on these findings alone who was not involved in the study.
Caution is in order, agreed go into leader Dr Honglei Chen, an investigator at the US National Institute of Environmental Health Sciences. "The scrutinize is preliminary and more investigation into the topic is needed". But the findings are "intriguing," and are dependable with a small but growing number of studies linking artificially sweetened drinks to poorer health.
The results were released by the American Academy of Neurology, up ahead of its annual encounter in San Diego in March 2013. The findings are based on more than 260000 Americans elderly 50 to 71 who reported on their usual beverage habits. About a decade later, they were asked whether they'd been diagnosed with dejection in the past several years.
Older adults who down several house drinks a epoch may have a heightened risk of developing depression, a unfamiliar study suggests. Researchers found that of more than 260000 older adults in a US survey, those who had at least four everyday servings of artificially sweetened soda, iced tea or fruit punch were at increased jeopardize of being diagnosed with depression in the next decade. People with a taste for sugar-sweetened drinks also showed a higher recession risk versus those who avoided the beverages. But the link was weaker than the one between diet drinks and depression, according to the study, which was released Jan 8, 2013.
On the other hand, coffee lovers had a minor extent crop depression risk than people who typically passed on the java. What it all means, however, is anyone's guess. "This unquestionably creates more questions than it answers," said Eva Redei, a professor of psychiatry at the Northwestern University Feinberg School of Medicine in Chicago. And it unquestionably is not doable to lay the blame on diet drinks themselves, based on these findings alone who was not involved in the study.
Caution is in order, agreed go into leader Dr Honglei Chen, an investigator at the US National Institute of Environmental Health Sciences. "The scrutinize is preliminary and more investigation into the topic is needed". But the findings are "intriguing," and are dependable with a small but growing number of studies linking artificially sweetened drinks to poorer health.
The results were released by the American Academy of Neurology, up ahead of its annual encounter in San Diego in March 2013. The findings are based on more than 260000 Americans elderly 50 to 71 who reported on their usual beverage habits. About a decade later, they were asked whether they'd been diagnosed with dejection in the past several years.
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